Full 100-Question Study Guide Comprehensive Questions
with Answers and Explanations| PDF
Topics Covered: Cardiovascular, Respiratory, Renal, Digestive, Endocrine, Nervous Systems,
and Integrative Physiology
Cardiovascular Physiology
Q1. The primary pacemaker of the heart is:
A) Sinoatrial (SA) node
B) Atrioventricular (AV) node
C) Purkinje fibers
D) Bundle of His
Explanation: The SA node initiates the heartbeat.
Q2. During ventricular systole, which valves are open?
A) AV valves
B) Semilunar valves (aortic and pulmonary)
C) All valves
D) Only mitral valve
Explanation: Semilunar valves allow blood to exit the ventricles.
Q3. Stroke volume is influenced by:
A) Heart rate only
B) Blood pressure only
C) Preload, afterload, and contractility
D) Venous return only
Explanation: All three factors determine the amount of blood
ejected.
,Q4. The Frank-Starling law describes:
A) Greater ventricular filling increases stroke volume
B) Heart rate directly proportional to BP
C) BP independent of stroke volume
D) Cardiac output is fixed
Explanation: Stretch of cardiac muscle fibers enhances
contraction.
Q5. Baroreceptors detect changes in:
A) Blood pressure
B) Oxygen levels
C) CO₂ levels
D) Sodium concentration
Explanation: Located in carotid sinus and aortic arch to maintain
BP.
Q6. Sympathetic stimulation affects the heart by:
A) Increasing heart rate and contractility
B) Decreasing heart rate
C) No effect
D) Only affects AV conduction
Explanation: Norepinephrine binds β1 receptors to increase
cardiac output.
Q7. The mean arterial pressure (MAP) can be approximated as:
A) Diastolic pressure + 1/3 pulse pressure
B) Systolic + diastolic / 2
C) Heart rate × stroke volume
D) Pulse pressure only
Explanation: Reflects the average blood pressure during cardiac
cycle.
, Q8. Which ion primarily mediates the depolarization phase of cardiac
action potentials?
A) Sodium (Na⁺)
B) Potassium (K⁺)
C) Calcium (Ca²⁺)
D) Chloride (Cl⁻)
Explanation: Rapid influx of Na⁺ initiates the upstroke.
Q9. Capillaries are the main site of:
A) Exchange of gases, nutrients, and waste
B) Pressure generation
C) Blood storage
D) Oxygen transport only
Explanation: Thin walls allow diffusion between blood and
tissues.
Q10. Venous return is aided by:
A) Skeletal muscle pump and respiratory pump
B) Only gravity
C) Arterial pressure alone
D) None of the above
Explanation: Muscle contractions and thoracic pressure changes
move blood back to the heart.
Respiratory Physiology
Q11. The diaphragm contracts during:
A) Inspiration
B) Expiration
C) Forced expiration only