UAMS Hematology Exam 3 UPDATED ACTUAL Questions and CORRECT
Answers
The bone marrow is one of the largest Organs. Compromises 4% of our body weight.
(blank) in the body
Bone marrow is found in what bones of All bones in infants. Only flat bones in adults.
infants? What bones of adults?
Where are erythrocytes found in the bone sinus near macrophage
marrow?
Macrophage brings what to RBCs? Iron
Megakaryocytes are near Sinus well. Direct entry of mature platelets
Lymphedema are random and leave BM to proliferate in lymph tissue to form antigen DEPENDENT cells & antibodies
do what
Mesh work of Stromal cells form what? The foundation or support
-Reticulum that extends into the marrow cords.
Mesh work of stromal cells are -Fat (50% fat, 50% tissue)
compromised of what? -histiocytes
-endothelial cells
Bone forming cells in BM Osteoblasts
Bone destroying cells in BM Osteoclasts
DNA; seen in post-splenectomy, Howell Jolly Body
megaloblastic anemias, some hemolytic
anemias
RNA; associated with decreased RBC Reticulocyte
survival/hemorrhage, erythropoietin hyper
plastic marrow
Iron; seen in wider oblast in anemia, Pappenheimer body
thalassemia
, Precipitated hemoglobin; seen in G6PD Heinz's body
deficiency. Can only been seen with
supravital stain
Crystallized hemoglobin C C crystal
Iron Ringed sideroblast
RNA aggregates; seen in thalassemia and Basophilic stippling
lead poisoning
Nucleated RBC DNA
How is automated hematocrit calculated ? HCT= RBCxMCV/10
What will affect MCV? Agglutination
What will increased WBC affect? RBC count
Lipemia will affect what? Hemoglobin. NOT HCT
How to calculate MCV MCV= HCTx10/RBC
How to calculate MCH MCH= Hgbx10/RBC
How to calculate MCHC MCHC= Hgbx100/HCT
-defective DNA synthesis from B12 or folate (poor diet)
-bone marrow will show asynchrony, karryohexis, Giant metamyelocytes and bands.
-hypersegmented neutrophils
Megaloblastic Anemia (macro) -pancytopenia
-treat with replacement vitamin therapy
-decreased retic
-increased direct & indirect bilirubin and LD
Pernicious Anemia (macro) Lack of intrinsic factor which is involved in the absorption of B12. Schilling test
-hypo, micro
-chronic blood loss is the most common reason in adults
-poor diet
iron deficiency anemia
-decreased serum Fe, decreased Ferritin
-increased TIBC
-retic increases only after therapy
-decreased serum Fe, decreased TIBC
Anemia of chronic disease (micro) -increased ferritin
-treat underlying condition first (GI bleed)
-hypo, micro
-beta chains reduced or absent
-increased in alpha chains
Beta thalassemia (micro)
-common in Mediterranean, south East Asians, and Africa
-target cells & basophilic stippling in peripheral blood
-electrophoresis increased A2 and F
-hypo, micro
Alpha thalassemia -hydrops details (alpha thalassemia major): 4 gene deletion
-incompatible with life
-decreased haptoglobjn
Hemolysis
-increased bilirubin, LD, & retic
What is the most common hemolytic Malaria
anemia in the world?
Answers
The bone marrow is one of the largest Organs. Compromises 4% of our body weight.
(blank) in the body
Bone marrow is found in what bones of All bones in infants. Only flat bones in adults.
infants? What bones of adults?
Where are erythrocytes found in the bone sinus near macrophage
marrow?
Macrophage brings what to RBCs? Iron
Megakaryocytes are near Sinus well. Direct entry of mature platelets
Lymphedema are random and leave BM to proliferate in lymph tissue to form antigen DEPENDENT cells & antibodies
do what
Mesh work of Stromal cells form what? The foundation or support
-Reticulum that extends into the marrow cords.
Mesh work of stromal cells are -Fat (50% fat, 50% tissue)
compromised of what? -histiocytes
-endothelial cells
Bone forming cells in BM Osteoblasts
Bone destroying cells in BM Osteoclasts
DNA; seen in post-splenectomy, Howell Jolly Body
megaloblastic anemias, some hemolytic
anemias
RNA; associated with decreased RBC Reticulocyte
survival/hemorrhage, erythropoietin hyper
plastic marrow
Iron; seen in wider oblast in anemia, Pappenheimer body
thalassemia
, Precipitated hemoglobin; seen in G6PD Heinz's body
deficiency. Can only been seen with
supravital stain
Crystallized hemoglobin C C crystal
Iron Ringed sideroblast
RNA aggregates; seen in thalassemia and Basophilic stippling
lead poisoning
Nucleated RBC DNA
How is automated hematocrit calculated ? HCT= RBCxMCV/10
What will affect MCV? Agglutination
What will increased WBC affect? RBC count
Lipemia will affect what? Hemoglobin. NOT HCT
How to calculate MCV MCV= HCTx10/RBC
How to calculate MCH MCH= Hgbx10/RBC
How to calculate MCHC MCHC= Hgbx100/HCT
-defective DNA synthesis from B12 or folate (poor diet)
-bone marrow will show asynchrony, karryohexis, Giant metamyelocytes and bands.
-hypersegmented neutrophils
Megaloblastic Anemia (macro) -pancytopenia
-treat with replacement vitamin therapy
-decreased retic
-increased direct & indirect bilirubin and LD
Pernicious Anemia (macro) Lack of intrinsic factor which is involved in the absorption of B12. Schilling test
-hypo, micro
-chronic blood loss is the most common reason in adults
-poor diet
iron deficiency anemia
-decreased serum Fe, decreased Ferritin
-increased TIBC
-retic increases only after therapy
-decreased serum Fe, decreased TIBC
Anemia of chronic disease (micro) -increased ferritin
-treat underlying condition first (GI bleed)
-hypo, micro
-beta chains reduced or absent
-increased in alpha chains
Beta thalassemia (micro)
-common in Mediterranean, south East Asians, and Africa
-target cells & basophilic stippling in peripheral blood
-electrophoresis increased A2 and F
-hypo, micro
Alpha thalassemia -hydrops details (alpha thalassemia major): 4 gene deletion
-incompatible with life
-decreased haptoglobjn
Hemolysis
-increased bilirubin, LD, & retic
What is the most common hemolytic Malaria
anemia in the world?
