Immunology (UAMS) Exam 4 UPDATED
ACTUAL Questions and CORRECT
Answers
Secondary immune deficiencies - CORRECT ANSWER - Abnormality due to another
disorder, infection, or treatment
Diseases associated with secondary immune deficiencies - CORRECT ANSWER -
Hodgkins disease and lymphoma,
Leukemia,
Myeloma, macroglobulinemia
Infections associated with secondary immune deficiency - CORRECT ANSWER -
Bacterial, protozoal, helminthic and fungal
What other conditions is associated with secondary immune deficiency? - CORRECT
ANSWER - Burns, DM, malnutrition, surgical procedures/trauma, renal malfunction,
aging and alcoholic cirrhosis
What are the immunosuppressants associated with Secondary immunodeficiency? - CORRECT
ANSWER - Antimetabolites, corticosteroids and radiation
What are the primary B-cell deficiencies? - CORRECT ANSWER - Transient
agammaglobulinemia of infancy,
X-linked Brutons agammaglobulinemia,
IgA Deficiency,
Common Variable immunodeficiency
What are the cellular immunity deficiencies? - CORRECT ANSWER - DiGeorge
Anomaly,
,Purine-nucleoside phosphorylase (PNP) Deficiency
What are the combined deficiencies of cellular and humoral immunity? - CORRECT
ANSWER - Severe combined immunodeficiency (SCID),
Wiskott-Aldrich Syndrome,
Ataxia Telangiectasia
What are the oxidative metabolism disorders of neutrophil dysfunction? - CORRECT
ANSWER - Chronic Granulomatous Disease (CGD),
Myeloperioxidase deficiency
Leukocyte adhesion molecule deficiency is an immune deficiency under what type of WBC
dysfunction? - CORRECT ANSWER - Neutrophil
What are the sites where immune system may fail? - CORRECT ANSWER - T Cells,
B Cells,
Phagocytic Cells,
Complement
Regulation disruption is described as? - CORRECT ANSWER - Where a defect in one
system may cause hyper-reactivity in another
Which immunodeficiency states are associated with allergic or autoimmune manifestations? -
CORRECT ANSWER - Partial Immunodeficiency States
These syndromes are relatively rare (Minus IgA Deficiency), include inherited defects of the
immune system and patients present with recurring infections - CORRECT ANSWER -
Primary Immunodeficiency Syndromes
, Defects in this immunity present with pyrogenic bacterial infections of the upper and lower
respiratory track
(normal amount of viral infections as normal populace) - CORRECT ANSWER -
Humoral Immunity Defect
At birth there are very low levels of these immunoglobulins - CORRECT ANSWER - IgA
and IgM
At birth there are adult levels of these immunoglobulins - CORRECT ANSWER - IgG
Decrease as age progresses and maternal IgG's are metabolized
Genetic defects in B Cell maturation or defective T and B cells interactions are
immunodeficiencies that fall under which type of immunodefieicy, primary or secondary? -
CORRECT ANSWER - Primary
Prolonged low levels of immunoglobulins where children have problems with infections and
delay of normal Ig levels has been attributed to poor T Cell help is a primary immunodeficiency
condition termed what? - CORRECT ANSWER - Transient Agammaglobulinemia of
infancy
This is an X-linked condition seen almost exclusively in males where there is a lack of mature B-
lymphs and all classes of Ig where the tonsils and adenoids are small or absent and T cells are
found to be normal. - CORRECT ANSWER - X-linked Bruton's agammaglobulinemia
In X-linked Agammaglobulinemia the development of B Cells is blocked from the Pro-B to Pre-
B stage and causes a failure of Vh gene rearrangement due to the lack of this enzyme -
CORRECT ANSWER - Bruton tyrosine kinase
What are the differentiation factors of transient agammaglobulinemia and x-linked Bruton's
agammaglobulinemia? - CORRECT ANSWER - Histological differences in lymphoid
tissues, (x-linked abnormal) and the persistence beyond age 2
ACTUAL Questions and CORRECT
Answers
Secondary immune deficiencies - CORRECT ANSWER - Abnormality due to another
disorder, infection, or treatment
Diseases associated with secondary immune deficiencies - CORRECT ANSWER -
Hodgkins disease and lymphoma,
Leukemia,
Myeloma, macroglobulinemia
Infections associated with secondary immune deficiency - CORRECT ANSWER -
Bacterial, protozoal, helminthic and fungal
What other conditions is associated with secondary immune deficiency? - CORRECT
ANSWER - Burns, DM, malnutrition, surgical procedures/trauma, renal malfunction,
aging and alcoholic cirrhosis
What are the immunosuppressants associated with Secondary immunodeficiency? - CORRECT
ANSWER - Antimetabolites, corticosteroids and radiation
What are the primary B-cell deficiencies? - CORRECT ANSWER - Transient
agammaglobulinemia of infancy,
X-linked Brutons agammaglobulinemia,
IgA Deficiency,
Common Variable immunodeficiency
What are the cellular immunity deficiencies? - CORRECT ANSWER - DiGeorge
Anomaly,
,Purine-nucleoside phosphorylase (PNP) Deficiency
What are the combined deficiencies of cellular and humoral immunity? - CORRECT
ANSWER - Severe combined immunodeficiency (SCID),
Wiskott-Aldrich Syndrome,
Ataxia Telangiectasia
What are the oxidative metabolism disorders of neutrophil dysfunction? - CORRECT
ANSWER - Chronic Granulomatous Disease (CGD),
Myeloperioxidase deficiency
Leukocyte adhesion molecule deficiency is an immune deficiency under what type of WBC
dysfunction? - CORRECT ANSWER - Neutrophil
What are the sites where immune system may fail? - CORRECT ANSWER - T Cells,
B Cells,
Phagocytic Cells,
Complement
Regulation disruption is described as? - CORRECT ANSWER - Where a defect in one
system may cause hyper-reactivity in another
Which immunodeficiency states are associated with allergic or autoimmune manifestations? -
CORRECT ANSWER - Partial Immunodeficiency States
These syndromes are relatively rare (Minus IgA Deficiency), include inherited defects of the
immune system and patients present with recurring infections - CORRECT ANSWER -
Primary Immunodeficiency Syndromes
, Defects in this immunity present with pyrogenic bacterial infections of the upper and lower
respiratory track
(normal amount of viral infections as normal populace) - CORRECT ANSWER -
Humoral Immunity Defect
At birth there are very low levels of these immunoglobulins - CORRECT ANSWER - IgA
and IgM
At birth there are adult levels of these immunoglobulins - CORRECT ANSWER - IgG
Decrease as age progresses and maternal IgG's are metabolized
Genetic defects in B Cell maturation or defective T and B cells interactions are
immunodeficiencies that fall under which type of immunodefieicy, primary or secondary? -
CORRECT ANSWER - Primary
Prolonged low levels of immunoglobulins where children have problems with infections and
delay of normal Ig levels has been attributed to poor T Cell help is a primary immunodeficiency
condition termed what? - CORRECT ANSWER - Transient Agammaglobulinemia of
infancy
This is an X-linked condition seen almost exclusively in males where there is a lack of mature B-
lymphs and all classes of Ig where the tonsils and adenoids are small or absent and T cells are
found to be normal. - CORRECT ANSWER - X-linked Bruton's agammaglobulinemia
In X-linked Agammaglobulinemia the development of B Cells is blocked from the Pro-B to Pre-
B stage and causes a failure of Vh gene rearrangement due to the lack of this enzyme -
CORRECT ANSWER - Bruton tyrosine kinase
What are the differentiation factors of transient agammaglobulinemia and x-linked Bruton's
agammaglobulinemia? - CORRECT ANSWER - Histological differences in lymphoid
tissues, (x-linked abnormal) and the persistence beyond age 2
