UAMS Hematology Exam 3 UPDATED
Questions and CORRECT Answers
Howell Jolly Body: - CORRECT ANSWER - DNA; seen in post-splenectomy,
megaloblastic anemias, anemias
Reticulocyte: - CORRECT ANSWER - RNA; associated with decreased RBC
survival/hemorrhage, hyperplastic marrow
Pappenheimer body: - CORRECT ANSWER - Iron; seen in sideroblastic anemia,
thalassemia
• Heinz Body: - CORRECT ANSWER - Body: Precipitated Hemoglobin; seen in G6PD
deficiency Can only be seen with supravital stain
Ringed Sideroblast: - CORRECT ANSWER - Iron
Basophilic stippling: - CORRECT ANSWER - RNA aggregates; seen in thalassemia and
lead poisoning
NRBC: - CORRECT ANSWER - DNA
Agglutination will affect - CORRECT ANSWER - MCV
Increased WWBC will affect - CORRECT ANSWER - RBC count
Lipemia will affect Hemoglobin, NOT - CORRECT ANSWER - HCT
,Megaloblastic Anemia - CORRECT ANSWER - Defective DNA synthesis from B12 or
Folate poor diet
Megaloblastic Anemia Bone marrow will show - CORRECT ANSWER - asynchrony,
karryohexis, giant metamyelocytes and bands Hypersegmented Neutrophils
Megaloblastic Anemia Lab results - CORRECT ANSWER - Pancytopenia Treat with
replacement vitamin therapy
• Decrease Retic
• Increase Direct and indirect bilirubin and LD
Inherited defect in spectrin - CORRECT ANSWER - Hereditary Spherocytosis
Hereditary Spherocytosis - CORRECT ANSWER - Decreased cell surface Peripheral
smear: Spherocytes (MCHC >36%) Polychromasia • 1 Osmotic fragility with hemolysis
beginning at a NaCl concentration
Auto Immune Hemolytic Anemia - CORRECT ANSWER - Spherocytes Polychromasia
+DAT
Sex-linked, decrease in enzyme - CORRECT ANSWER - G-6-PD
G-6-PD Oxidant drugs cause - CORRECT ANSWER - hemoglobin to denature and
precipitate
G-6-PD Most often occurs - CORRECT ANSWER - hemoglobin in black males
• Heinz bodies seen with Methylene Blue - CORRECT ANSWER - G-6-PD
,Pyruvate Kinase - CORRECT ANSWER - causing potassium loss as well as sodium
Reduced ATP production results in alterations of RBC membrane, failure of cation pumps loss,
which leads to cell dehydration
• Peripheral Smear: • Echinocytes
Beta Chain substitution (B6Glu->Val) - CORRECT ANSWER - Sickle Cell
Sickle Cell - CORRECT ANSWER - Sickle Solubility + • Confirm with Hb
electrophoresis • Sickle Cells Target Cells
Beta Chain substitute - CORRECT ANSWER - Hgb C • Hgb E
• C crystals • Target cells - CORRECT ANSWER - Hgb C
Differentiate from C on cellulose and A on citrate - CORRECT ANSWER - • Hgb E
• Beta Chain substitute Mild Hemolytic Anemia - CORRECT ANSWER - • Hgb E
RETIC Increased - CORRECT ANSWER - after treatment for IDA, folate, B12
RETIC VALUES Increased in - CORRECT ANSWER - spherocytosis
RETIC VALUES aplastic anemia - CORRECT ANSWER - Normal or decreased
RETIC VALUES Increased after treatment - CORRECT ANSWER - for IDA, folate, B12
RETIC VALUES Decreased in - CORRECT ANSWER - untreated Iron, B12, Folate
deficiency
, Calculate the indices of a Hgb of 8.0 g/dL. - CORRECT ANSWER - Cannot determine.
When is basophilic stippling observed? - CORRECT ANSWER - Thalassemia, lead
poisoning, megaloblastic anemia, sickle cell
What is the M:E ratio in anemia? - CORRECT ANSWER - • 1:1
• In a normal bone marrow, what percentage of white blood cells are the mature cells? -
CORRECT ANSWER - • 50% of neutrophils are myelocytes, metamyleocytes, bands and
segs
• What is an advantage of using automated instruments? - CORRECT ANSWER -
Increased precision
What is myeloid: erythroid ratio for erythroid hyperplasia? - CORRECT ANSWER - • 1:1
the normal M:E ratio? - CORRECT ANSWER - • 3:1
• In aplastic anemia, what is the bone marrow fat to cell ratio? - CORRECT ANSWER -
90:10
If the wrong type of blood is transfused, what type of hemolysis is found? - CORRECT
ANSWER - Intravascular
Which chemistry tests are elevated in hemolytic anemia? - CORRECT ANSWER -
Bilirubin and LD
Which group of anemias has the most polychromasia? - CORRECT ANSWER -
Hemolytic Anemias
Questions and CORRECT Answers
Howell Jolly Body: - CORRECT ANSWER - DNA; seen in post-splenectomy,
megaloblastic anemias, anemias
Reticulocyte: - CORRECT ANSWER - RNA; associated with decreased RBC
survival/hemorrhage, hyperplastic marrow
Pappenheimer body: - CORRECT ANSWER - Iron; seen in sideroblastic anemia,
thalassemia
• Heinz Body: - CORRECT ANSWER - Body: Precipitated Hemoglobin; seen in G6PD
deficiency Can only be seen with supravital stain
Ringed Sideroblast: - CORRECT ANSWER - Iron
Basophilic stippling: - CORRECT ANSWER - RNA aggregates; seen in thalassemia and
lead poisoning
NRBC: - CORRECT ANSWER - DNA
Agglutination will affect - CORRECT ANSWER - MCV
Increased WWBC will affect - CORRECT ANSWER - RBC count
Lipemia will affect Hemoglobin, NOT - CORRECT ANSWER - HCT
,Megaloblastic Anemia - CORRECT ANSWER - Defective DNA synthesis from B12 or
Folate poor diet
Megaloblastic Anemia Bone marrow will show - CORRECT ANSWER - asynchrony,
karryohexis, giant metamyelocytes and bands Hypersegmented Neutrophils
Megaloblastic Anemia Lab results - CORRECT ANSWER - Pancytopenia Treat with
replacement vitamin therapy
• Decrease Retic
• Increase Direct and indirect bilirubin and LD
Inherited defect in spectrin - CORRECT ANSWER - Hereditary Spherocytosis
Hereditary Spherocytosis - CORRECT ANSWER - Decreased cell surface Peripheral
smear: Spherocytes (MCHC >36%) Polychromasia • 1 Osmotic fragility with hemolysis
beginning at a NaCl concentration
Auto Immune Hemolytic Anemia - CORRECT ANSWER - Spherocytes Polychromasia
+DAT
Sex-linked, decrease in enzyme - CORRECT ANSWER - G-6-PD
G-6-PD Oxidant drugs cause - CORRECT ANSWER - hemoglobin to denature and
precipitate
G-6-PD Most often occurs - CORRECT ANSWER - hemoglobin in black males
• Heinz bodies seen with Methylene Blue - CORRECT ANSWER - G-6-PD
,Pyruvate Kinase - CORRECT ANSWER - causing potassium loss as well as sodium
Reduced ATP production results in alterations of RBC membrane, failure of cation pumps loss,
which leads to cell dehydration
• Peripheral Smear: • Echinocytes
Beta Chain substitution (B6Glu->Val) - CORRECT ANSWER - Sickle Cell
Sickle Cell - CORRECT ANSWER - Sickle Solubility + • Confirm with Hb
electrophoresis • Sickle Cells Target Cells
Beta Chain substitute - CORRECT ANSWER - Hgb C • Hgb E
• C crystals • Target cells - CORRECT ANSWER - Hgb C
Differentiate from C on cellulose and A on citrate - CORRECT ANSWER - • Hgb E
• Beta Chain substitute Mild Hemolytic Anemia - CORRECT ANSWER - • Hgb E
RETIC Increased - CORRECT ANSWER - after treatment for IDA, folate, B12
RETIC VALUES Increased in - CORRECT ANSWER - spherocytosis
RETIC VALUES aplastic anemia - CORRECT ANSWER - Normal or decreased
RETIC VALUES Increased after treatment - CORRECT ANSWER - for IDA, folate, B12
RETIC VALUES Decreased in - CORRECT ANSWER - untreated Iron, B12, Folate
deficiency
, Calculate the indices of a Hgb of 8.0 g/dL. - CORRECT ANSWER - Cannot determine.
When is basophilic stippling observed? - CORRECT ANSWER - Thalassemia, lead
poisoning, megaloblastic anemia, sickle cell
What is the M:E ratio in anemia? - CORRECT ANSWER - • 1:1
• In a normal bone marrow, what percentage of white blood cells are the mature cells? -
CORRECT ANSWER - • 50% of neutrophils are myelocytes, metamyleocytes, bands and
segs
• What is an advantage of using automated instruments? - CORRECT ANSWER -
Increased precision
What is myeloid: erythroid ratio for erythroid hyperplasia? - CORRECT ANSWER - • 1:1
the normal M:E ratio? - CORRECT ANSWER - • 3:1
• In aplastic anemia, what is the bone marrow fat to cell ratio? - CORRECT ANSWER -
90:10
If the wrong type of blood is transfused, what type of hemolysis is found? - CORRECT
ANSWER - Intravascular
Which chemistry tests are elevated in hemolytic anemia? - CORRECT ANSWER -
Bilirubin and LD
Which group of anemias has the most polychromasia? - CORRECT ANSWER -
Hemolytic Anemias
