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Protein insertion into the mammalian ER membrane is typically
cotranslational
The peroxisomeal targeting sequence, PTS1, is located in what region of the protein and is it
cleaved after entry of the protein into the organelle
C-terminus.... is not cleaved
Which of the following is not a recognized stage of protein synthesis in both prokaryotes and
eukaryotes
nuclear translocation
Which of the following factors recognizes the UAG, UAA and UGA codons
termination factors
Which codon serves as the start codon in mRNA for translation
AUG
Which of the following small GTPases are not involved in vesicle budding or docking?
ras
The enzyme in cholesterol biosynthesis subject to feedback inhibition is
HMG CoA reductase
Soluble and membrane proteins advance through the Golgi complex by
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, cisternal progression
Protein sorting of anterograde cargo to different destinations occurs within what region of the
Golgi complex?
trans-Golgi network
Atherosclerosis involves the formation of an atherosclerotic ______ in an artery
plaque
Protein import into the mitochondrial matrix is supported by energy input from
ATP hydrolysis by chaperone proteins in the cytosol, by chaperones in mitochondrial matrix and
and by the proton-motive force across the inner mitochondrial membrane
In eukaryotic cells, disulfide bonds are formed only in which organelle
endoplasmic reticulum
Acidification of endosomes is important in dissociating
iron from transferrin
During cisternal progression, resident proteins are returned to their appropriate cisterna by
which process?
retrograde vesicle transport
Vesicle fusing with their target membranes are coated or uncoated?
uncoated
In N-glycosylation of proteins in the ER lumen, _____ sugar (s) are added to the nascent chain at
once
14
The precursor oligosaccharide transferred to the growing polypeptide during N-linked
glycosylation uses which long-chain polyisoprenoid lipid as a carrier?
dolichol
The GTPases involved in vesicle budding and the uncoating of vesicles released from donor
membrane include which of the following?
ARP and Sar1
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