1
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patho 370 - week 2 Questions and
Answers (100% Correct Answers) Already
Graded A+
What is type I hypersensitivity and antigen form?—Ans: IgE and
soluble antigen
What is type II hypersensitivity?—Ans: IgG OR IgM and cell-bound
antigen
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What is type III hypersensitivity?—Ans: IgG AND IgM and soluble
antigen
What is type IV hypersensitvity?—Ans: T Cells and soluble or cell-
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bound antigen
What is type I hypersensitivity mechanism of activation?—Ans: -
Allergen-specific IgE antibodies bind to mast cells via their Fc
receptor.
-When the specific allergen binds to the IgE, cross-linking of IgE
induces degranulation of mast cells.
What is type II hypersensitivity mechanism of activation?—Ans: -
IgG or IgM antibody binds to cellular antigen, leading to
complement activation and cell lysis.
-IgG can also mediate ADCC with cytotoxic T cells, natural killer
cells, macrophages and neutrophils.
What is type III hypersensitivity mechanism of activation?—Ans: -
Antigen-antibody complexes are deposited on tissues.
, 2
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- Complement activation provides inflammatory mediators and
recruits neutrophils.
-Enzymes released neutrophils damage tissue.
What is type IV hypersensitivity mechanism of activation?—Ans: -
TH1 cells secrete cytokines, which activate macrophages and
cytotoxic T cells.
What is a type I hypersensitivity reaction?—Ans: - Local and
systemic anaphylaxis
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-Seasonal hay fever
- Food allergies
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- Drug allergies
What is a type II hypersensitivity reaction?—Ans: - RBC destruction
after transfusion with mismatched blood types during hemolytic
disease of the newborn
What is a type III hypersensitivity reaction?—Ans: - Post-
streptococcal glomerulonephritis
-Rheumatoid arthritis
-Systemic lupus erythematosus
What is a type IV hypersensitivity reaction?—Ans: - Contact
dermatitis
-Type I diabetes mellitus
-Multiple sclerosis
, 3
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(slowest)
What is excessive immune response?—Ans: A type of alteration in
immune function: over or hyper-function of immune system
What is deficient immune response?—Ans: A type of alteration in
immune function: ineffective immune response
What is autoimmunity?—Ans: Immune system attacks own tissues
What is the cause of autoimmunity?—Ans: Abnormal excessive
immune responses toward own
tissues.
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What is the MHC gene? (HLA)—Ans: Appear to increase risk of
autoimmune disorders
females at higher risk
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What is hypersensitivity?—Ans: -Describes the mechanism of injury
-May or may not involve autoimmunity
What is the treatment of autoimmunity?—Ans: Individualized
immunosuppressive therapy -
1. Corticosteroids and cytotoxins (MTX)
2. Tumor necrosis factor inhibitors and
immunomodulators - (Monoclobal Antibodies (MAB))
3. Therapeutic plasmapheresis
What is the mechanism of treatment for type I hypersensitivity of
IgE blocker therapy?—Ans: Inhibits binding of IgE to mast cells
(Only for Type I)
What is the mechanism of treatment for hypersensitivity of
antihistamines?—Ans: Block the effects of histamine
For Expert help and assignment solutions, +254707240657
patho 370 - week 2 Questions and
Answers (100% Correct Answers) Already
Graded A+
What is type I hypersensitivity and antigen form?—Ans: IgE and
soluble antigen
What is type II hypersensitivity?—Ans: IgG OR IgM and cell-bound
antigen
© 2025 Assignment Expert
What is type III hypersensitivity?—Ans: IgG AND IgM and soluble
antigen
What is type IV hypersensitvity?—Ans: T Cells and soluble or cell-
Guru01 - Stuvia
bound antigen
What is type I hypersensitivity mechanism of activation?—Ans: -
Allergen-specific IgE antibodies bind to mast cells via their Fc
receptor.
-When the specific allergen binds to the IgE, cross-linking of IgE
induces degranulation of mast cells.
What is type II hypersensitivity mechanism of activation?—Ans: -
IgG or IgM antibody binds to cellular antigen, leading to
complement activation and cell lysis.
-IgG can also mediate ADCC with cytotoxic T cells, natural killer
cells, macrophages and neutrophils.
What is type III hypersensitivity mechanism of activation?—Ans: -
Antigen-antibody complexes are deposited on tissues.
, 2
For Expert help and assignment solutions, +254707240657
- Complement activation provides inflammatory mediators and
recruits neutrophils.
-Enzymes released neutrophils damage tissue.
What is type IV hypersensitivity mechanism of activation?—Ans: -
TH1 cells secrete cytokines, which activate macrophages and
cytotoxic T cells.
What is a type I hypersensitivity reaction?—Ans: - Local and
systemic anaphylaxis
© 2025 Assignment Expert
-Seasonal hay fever
- Food allergies
Guru01 - Stuvia
- Drug allergies
What is a type II hypersensitivity reaction?—Ans: - RBC destruction
after transfusion with mismatched blood types during hemolytic
disease of the newborn
What is a type III hypersensitivity reaction?—Ans: - Post-
streptococcal glomerulonephritis
-Rheumatoid arthritis
-Systemic lupus erythematosus
What is a type IV hypersensitivity reaction?—Ans: - Contact
dermatitis
-Type I diabetes mellitus
-Multiple sclerosis
, 3
For Expert help and assignment solutions, +254707240657
(slowest)
What is excessive immune response?—Ans: A type of alteration in
immune function: over or hyper-function of immune system
What is deficient immune response?—Ans: A type of alteration in
immune function: ineffective immune response
What is autoimmunity?—Ans: Immune system attacks own tissues
What is the cause of autoimmunity?—Ans: Abnormal excessive
immune responses toward own
tissues.
© 2025 Assignment Expert
What is the MHC gene? (HLA)—Ans: Appear to increase risk of
autoimmune disorders
females at higher risk
Guru01 - Stuvia
What is hypersensitivity?—Ans: -Describes the mechanism of injury
-May or may not involve autoimmunity
What is the treatment of autoimmunity?—Ans: Individualized
immunosuppressive therapy -
1. Corticosteroids and cytotoxins (MTX)
2. Tumor necrosis factor inhibitors and
immunomodulators - (Monoclobal Antibodies (MAB))
3. Therapeutic plasmapheresis
What is the mechanism of treatment for type I hypersensitivity of
IgE blocker therapy?—Ans: Inhibits binding of IgE to mast cells
(Only for Type I)
What is the mechanism of treatment for hypersensitivity of
antihistamines?—Ans: Block the effects of histamine
