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UWorld Test Comprehensive Questions with Verified Answers Graded A+

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UWorld Test Comprehensive Questions with Verified Answers Graded A+

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November 5, 2025
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2025/2026
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UWorld Test Comprehensive
Questions with Verified
Answers Graded A+
Treatment for Akathesia? - Answer: Feeling of restlessness

Beta Blockers



Treatment for acute dystonia? - Answer: Anti-histamines and Dopamine Agonists (benztropine
or trihexyphenidol)



Long term neurlogic sequelae associated with bacterial meningitis? - Answer: 1.) Hearing Loss

2.) Loss of cognitive functions ( neuronal loss of the dentate gyrus in the hippocampus)

3.) seizures

4.) mental retardation

5.) spacticity or paresis



Antibodies prevalent in Hashimoto's Thyroiditis? - Answer: Anti-thyroid Peroxidase (TPO) and
Anti-thyroglobulin antibodies.



Treatment for Cat Scratch Disease? - Answer: Usually self-resolves. But Azithromycin can speed
recovery.



What is reaction formation? - Answer: An neurotic defense mechanism in which a person does
exactly of what he/she feels to cover socially unacceptable thoughts.

,What is suppression? - Answer: A mature defense mechanism in which a person voluntary
suppresses unpleasant thoughts.



What is optic neuritis? - Answer: Central scotoma, afferent pupillary defect, changes in color
perception, and decreased visual acuity.



What is sympathetic opthalmia? - Answer: Damage of one eye after a penetrating injury to the
other eye it is 2/2 immunologic mechanism of uncovering of hidden antigens.



Risk factors for adenocarcinoma of esophagus? - Answer: Barrett's Esophagus, GERD, high fat
and calorie diet.



Risk factors for squamous cell ca of esophagus? - Answer: Smoking, alcohol, vitamin def, and
pickled foods.



Treatment for Immune thrombocytopenia? - Answer: Self-resolves--->observe.

If platelet count falls below 30,000 treat with Corticosteroids.



Side effect of Isoniazid? - Answer: 1.) Peripheral Neuropathy

2.) Hepatitis



What is Cauda equina Syndrome? - Answer: Saddle anesthesia, bowel and bladder dysfunction,
and low back pain.



Txt for Pneumonia in a CF patient? - Answer: Most likely Pseudomonas. txt with
Cephalosporin/Penicillin + aminoglycoside.

,Side effect of carbamezepine? - Answer: Aplastic Anemia



Describe an essential tremor? - Answer: Tremor that is suppressed at rest but exacerbated
toward the end of a goal directed activity.



Txt for Essential Tremor? - Answer: First line is Propranolol.

Can also try Primodine or Topirimate.



Normal light microscopic findings in a patient with Nephrotic syndrome suggest what? - Answer:
Minimal Change disease



Describe Diffuse Esophageal Spasm? - Answer: Spontaneous pain and discomfort with hot or
cold food. Best to proceed with Esophageal motlitiy study will reveal non-peristaltic, high
amplitude contractions.



S/S of Constrictive Pericarditis? - Answer: Elevated JVP, hepatomegaly, ascites.

2/2 Radiation, viral infection, or cardiac surgery.



Txt for Constrictive Pericarditis? - Answer: Diuretics or Pericardiectomy



Characteristics of Histoplasmosis? - Answer: Found in Ohio river valley. Palatal ulcers,
hepatosplenomegaly, and pancytopenia.

CXR will reveal interstitial pneumonitis.



Characteristics of Blastomycosis? - Answer: Found in soil or rotting wood. CXR will reveal
multiple nodules or dense consolidation. Can cause skin lesions, osteolytic bone lesion, and
prostate involvement. Not usually seen in immunocompromised hosts.

, What does elevated transaminase levels indicate? - Answer: Ongoing hepatocyte damage as
enzymes leak from cells.



Best test to asses damage of liver? - Answer: Elevated PT



Common findings seen in Paget's disease? - Answer: Due hyperfunctioning Osteoclasts. Elevated
Alk. Phosph., femoral bowing on x-ray, and loss of CN VII activity due to enlarging cranial bones.



Imaging study for child with developmental dysplasia of the hip? - Answer: If < 4 months -
Ultrasound

if > 4 months - X-ray



Which virus is nasopharyngeal cancer associated with? - Answer: High incidence with Epstein
Barr Virus



Lab findings associated with Anti-phospholipid Syndrome? - Answer: 1. Will have positive VDRL
but negative FTA-ABS

2. Prlonged PTT

3. Thrombocytopenia



Describe what imaging studies of invasive aspergilliosis would look like? - Answer: CXR: rapidly
progressive dense consolidation

CT: Pulmonary nodules with "Halo" signs or lesions with air crescent.



Next step when patient presents with Alkali ingestion? - Answer: Upper GI endoscopy



What is Enthesitis? - Answer: Inflammation and pain occur at site of insertion of tendons and
ligaments.

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