ONCOLOGY CERTIFICATION EXAM 2025/2026 QUESTIONS AND ANSWERS 100% PASS

ONCOLOGY CERTIFICATION EXAM
2025/2026 QUESTIONS AND ANSWERS
100% PASS




Amifostine - ANS Protects lungs from pneumonitis/radiation protective. Radioprotector.


Prevenge - ANS Vaccine that boosts immune response to cancer cells. For metastatic
prostate ca.


Alkylating agents - ANS Damage DNA to prevent ca cells from reproducing. Not phase
specific. Use to tx: leukemia, lymphoma, Hodgkins, MM, sarcoma, lung, breast &a ovary. I.e.
Nitrogen mustard, cyclophos., nitrosoureas, Dacarbazine.


Antimetabolites - ANS Interfere with DNA and RNA growth by substituting the normal
building blocks of RNA & DNA. Damage cells during the s phase. used to treat leukemia, breast,
ovary, interstitial tract. cell cycle specific.


6 mercaptopurine (6-no) - ANS Antimetabolite.


Cladribine - ANS Antimetabolite. Given for HC leukemia, CLL, NHL. S/E decreased WBC,
infection, fever, N/V, TLS.


Capecitabine - ANS Antimetabolite


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,Clafarabine - ANS Antimetabolite


Floxuribine - ANS Antimetabolite


Gemcitabine - ANS


Nitrogen mustard - ANS Non-platin. Alkylating agent. Mechlorethamine, chlorabucil,
cyclophosphamide, ifosphamide, & melphalon. Vesicant


Nitrosourea - ANS Streptococin, carmustine, limustine.
Non-platin. Alkylating agent.


Alkyl sulfonate - ANS Busulfan. Alkylating agent, non-platin.


Thiazines - ANS Dacarbazine (DTIC) & temozolomide. Alkylating agent, non-playing.


ethylenimines - ANS Thiotepa & altretamine (hexmethylmelamine) alkylating agent/ non-
platin


Carboplatin - ANS Interferes with DNA replication, RNA transcription & nucleus acid function.
Cell cycle non specific. alkylating agent. Given for ovarian, endometrial, lung, H&N. Irritant. N/V,
bronchospasm, Hypotention, thrombocytopenia, TLS.


Cisplatin - ANS Alkylating agent. Interferes with DNA replication/rNA transcription & nuclei
acid fx. Treatment for lung, H&N, c RBI all ca. s/e myelosuppression, N/V/D, ottotoxicity,
anaphylaxis, facial edema, bronchospasms, tachycardia, Cumulative renal toxicity severe, TLS


Oxalplatin - ANS Alkylating agent. Irritant. Interferes with DNA replication/RNA transcription
and nucleus acic fx. Avoid cold. S/e: N/V/D & neuropathy.




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, Platins - ANS Alkylating agents. interfere with DNA replication/RNA transcription & nucleic
acid fx! Cell cycle non specific.


Emergencies - ANS Oncology


Vesicants - ANS Doxorubicin, nitrogen mustard, mitomycin


DNA binding vesicants - ANS Anthracyclines, doxorubicin, nitrogen mustard and mitomycin.
Bind to nucleus acids of DNA in healthy cells causing cell death. This causes the cells to release
extra cellular substances that get taken up early by cells. As it remains & circulates the cycle
continues.


Non-DNAbindind vesicants - ANS Does not bind to DNA but has an indirect effect on healthy
cells. Resolve more easily. plAnt alkaloids and paclitaxol.


Cytokines/Cyclophosphamide - ANS Alkylating agent. For breast, NHL, ,CLL, sarcoma,
rhabdosarcoma, neuroblastoma, Wilma's tumor. Encourage fluid intake and empty bladder
frequently x24 Hrs. s/e decreased WBC, N/V, hair loss, nail changes, TLS, hemorrhagic cystitis,
H/A, mylelosuppression


Cytaribine/Area-C - ANS Antimetabolite. S/e: photosensitivity, myelosuppression, Hi toxic,
hand & foot syndrome, TLS


Dacarbazine(DTIC) - ANS Vesicant. Given for melanoma, Hodgkin, soft-tissue sarcomas,
neoroblastoma. S/e decreased WNC & PLTs, N/V, CNS toxicity, photosensitivity.


Daunorubicin(Anthracycline) - ANS Vesicant. Can cause permanent cardiotoxicity, cumulative
dose 550mg/m2. Turns urine red. N/V, mouth sores, hair loss.


Docetaxel(Taxotete) - ANS Vesicant. Tx for Breast, NSCLC, prostate, H& N, ovarian, bladder.
Contains alcohol. S/e: decreased WBC & PLT, RBCs, fluid retention, rash, nail changes, slope is,
N/V, fatigue, peripheral neuropathy.


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