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Examples of biguonides - 🧠 ANSWER ✔✔Metformin
Fortamet
Glucophage
Biguanides MOA - 🧠 ANSWER ✔✔Activates AMP-kinase to hepatic
glucose production
Buganides advantages - 🧠 ANSWER ✔✔Weight neutral
No hypoglycemia
,Modest decline in LDL
SE of biguanides - 🧠 ANSWER ✔✔Nausea
Diarrhea
Cramps
Rarely harmful buildup of lactic acid (lactic acidosis)
Examples of sulfonylureas - 🧠 ANSWER ✔✔Glipizide (Gluctrol)
Clmepride (Amaryl)
Glyburide
Glipazide
,Sulfonylureas MOA - 🧠 ANSWER ✔✔Closes KATP channels on beta cell
plasma membranes
Insulin secretion
Examples of rapid acting insulin - 🧠 ANSWER ✔✔Lispro (Humalog)
Aspart (Novolog)
Glulisine (Apidra)
Rapid acting insulin onset - 🧠 ANSWER ✔✔About 5 minutes
Rapid acting insulin peak - 🧠 ANSWER ✔✔About 1 hour
Rapid acting insulin duration - 🧠 ANSWER ✔✔4-5 hours
Examples of short acting insulin - 🧠 ANSWER ✔✔"Regular" (Humalin)
When is Humalin sometimes used - 🧠 ANSWER ✔✔Around meal time
When ins Humalin taken - 🧠 ANSWER ✔✔About 30-45 minutes before
eating
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, When does Humalin peak - 🧠 ANSWER ✔✔3-4 hours
Humalin duration - 🧠 ANSWER ✔✔4-10 hours
Characteristics of inermediate acting insulin - 🧠 ANSWER ✔✔Normal
pressure hydrocephalus mixed with protamine
Delaying absorption
Looks cloudy and has to be mixed before it is injected
Intermediate insulin onset - 🧠 ANSWER ✔✔30 minutes to 1 hour
Intermediate insulin peak - 🧠 ANSWER ✔✔4-10 hours
Intermediate insulin duration - 🧠 ANSWER ✔✔12-24 hours
Examples of long acting insulin - 🧠 ANSWER ✔✔Glargine (Lantus)
Detemir (Levemir)