and Answers | A+ Score Assured
What is the atopic triad - 🧠 ANSWER ✔✔Asthma
Atopic dermatitis
Allergic rhinitis
Initial asthma treatment - 🧠 ANSWER ✔✔Bronchodilators
-SABA
Examples of SABAs - 🧠 ANSWER ✔✔Albuterol
Levalbuterol
,SABA MOA - 🧠 ANSWER ✔✔SABAs work on the smooth muscles of the
lungs. SABAs target a receptor called the beta-2 receptor in the airways.
The drug activates the beta-2 receptor, and this helps relax the muscles in
the airway. As a result, breathing improves
Bronchodilation
Step up after bronchodilator use - 🧠 ANSWER ✔✔ICS
LABA
Leukotriene antagonists
What is used for acute asthma exacerbations - 🧠 ANSWER ✔✔IV
corticosteroids
Magnesium sulfate
Oxygen
,Asthma treatment includes - 🧠 ANSWER ✔✔•Inhaled steroids
•Short-acting beta agonists (SABAs)
•Long-acting beta agonists (LABAs)
•Long-acting muscarinic antagonists (LAMAs)
•Leukotriene receptor antagonists (LTRAs)
•Theophylline
•Asthma biologics
•Immunotherapy
Examples of ICS - 🧠 ANSWER ✔✔Ciclesonide (Alvesco)
Budesonide (Plmicort
Beclomethasone dipropionate (Qvar)
ICS MOA - 🧠 ANSWER ✔✔Inhaled corticosteroids (ICS) are the most
effective controllers of asthma. They suppress inflammation mainly by
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, switching off multiple activated inflammatory genes through reversing
histone acetylation via the recruitment of histone deacetylase 2 (HDAC2).
Examples of LABAs - 🧠 ANSWER ✔✔•Advair (fluticasone
propionate/salmeterol)
•Dulera (mometasone/formoterol fumarate)
•Symbicort (budesonide/formoterol fumarate)
•Breo (fluticasone furoate/vilanterol)
Examples of Leukotriene receptor antagonists (LTRAs) - 🧠 ANSWER
✔✔•Singulair (montelukast)
•Accolate (zafirlukast)
•Zyflo (zileuton)
LABA MOA - 🧠 ANSWER ✔✔highly specific agonist for Beta2 receptors
with a prolonged duration of action (12 hours)
Inhibit mast cell mediator release, plasma exudation and may reduce
sensory nerve activation.