Principles of Pharmacology- APEA Exam Questions AND
Correct Answers
A chemical synapse differs from an electrical synapse in that
the signal transmission:
is rapid.
requires a neurotransmitter.
is a passive process.
can occur in both directions. - ✔✔requires a neurotransmitter.
Acetylcholine works at the neuromuscular junction to
activate:
an emotional response.
smooth muscles.
the digestive process.
skeletal muscles. - ✔✔skeletal muscles.
Activation of alpha-1 receptors does NOT:
cause vasoconstriction.
cause mydriasis.
increase closure of the internal bladder sphincter.
inhibit insulin release. - ✔✔inhibit insulin release.
,After a drug is metabolized by the liver and enters the bile, it
is most likely to be:
excreted in the urine.
fecally excreted.
bound to plasma proteins.
reabsorbed into the portal vein. - ✔✔fecally excreted.
Distribution of a drug is determined by the:
amount of drug entering circulation.
proportion of drug removed from circulation.
chemical alteration of a drug to a water-soluble state.
reversible transfer of drug from one location to another
within the body. - ✔✔reversible transfer of drug from one
location to another within the body.
Drugs that accumulate in tissues:
always cause toxicity.
are prone to higher degrees of side effects.
keep blood levels of drug from decreasing rapidly.
, must be administered at higher doses. - ✔✔keep blood levels
of drug from decreasing rapidly.
Electrical synapse differs from chemical synapse in that signal
transmission:
requires energy.
causes a modification of the signals.
can occur in both directions.
occurs at a slower pace. - ✔✔can occur in both directions.
Fick's Law of Diffusion describes drug mobility as the:
binding of drugs to protein in order to move down a
concentration gradient, across a membrane.
movement of free water molecules across a semipermeable
membrane, down a concentration gradient.
passive diffusion of non-ionized drugs down a concentration
gradient from an area of high concentration to low
concentration.
ionized drugs diffuse actively down a concentration gradient
from high concentration to low concentration. - ✔✔passive
diffusion of non-ionized drugs down a concentration gradient
from an area of high concentration to low concentration.
Correct Answers
A chemical synapse differs from an electrical synapse in that
the signal transmission:
is rapid.
requires a neurotransmitter.
is a passive process.
can occur in both directions. - ✔✔requires a neurotransmitter.
Acetylcholine works at the neuromuscular junction to
activate:
an emotional response.
smooth muscles.
the digestive process.
skeletal muscles. - ✔✔skeletal muscles.
Activation of alpha-1 receptors does NOT:
cause vasoconstriction.
cause mydriasis.
increase closure of the internal bladder sphincter.
inhibit insulin release. - ✔✔inhibit insulin release.
,After a drug is metabolized by the liver and enters the bile, it
is most likely to be:
excreted in the urine.
fecally excreted.
bound to plasma proteins.
reabsorbed into the portal vein. - ✔✔fecally excreted.
Distribution of a drug is determined by the:
amount of drug entering circulation.
proportion of drug removed from circulation.
chemical alteration of a drug to a water-soluble state.
reversible transfer of drug from one location to another
within the body. - ✔✔reversible transfer of drug from one
location to another within the body.
Drugs that accumulate in tissues:
always cause toxicity.
are prone to higher degrees of side effects.
keep blood levels of drug from decreasing rapidly.
, must be administered at higher doses. - ✔✔keep blood levels
of drug from decreasing rapidly.
Electrical synapse differs from chemical synapse in that signal
transmission:
requires energy.
causes a modification of the signals.
can occur in both directions.
occurs at a slower pace. - ✔✔can occur in both directions.
Fick's Law of Diffusion describes drug mobility as the:
binding of drugs to protein in order to move down a
concentration gradient, across a membrane.
movement of free water molecules across a semipermeable
membrane, down a concentration gradient.
passive diffusion of non-ionized drugs down a concentration
gradient from an area of high concentration to low
concentration.
ionized drugs diffuse actively down a concentration gradient
from high concentration to low concentration. - ✔✔passive
diffusion of non-ionized drugs down a concentration gradient
from an area of high concentration to low concentration.
