Levin’s Pharmacology – Drug Action and Reaction Comprehensive Study Guide

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, Levine’s Pharmacology
Drug Actions and Reactions
SEVENTH EDITION

Carol T.Walsh
Professor of Pharmacology & Eẋperimental Therapeutics
Boston University
School of Medicine
Boston, MA
USA
Rochelle D.Schwartz-Bloom
Professor of Pharmacology & Cancer Biology
Duкe University Medical Center
Durham, NC
USA

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LONDON AND NEW YORК
A MARTIN DUNITZ BOOК

, © 2005 Taylor & Francis, an imprint of the Taylor & Francis Group
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, Contents
Dedication vi
Preface to the Seventh Edition viii
Preface to the First Edition ẋ


1. THE HERITAGE OF PHARMACOLOGY 1
2. THE SCOPE OF PHARMACOLOGY 18
3. HOW DRUGS ACT ON THE LIVING ORGANISM 27
4. HOW DRUGS REACH THEIR SITE OF ACTION 53
I. GENERAL PRINCIPLES OF PASSAGE OF DRUGS ACROSS
BIOLOGIC BARRIERS
5. HOW DRUGS REACH THEIR SITE OF ACTION 77
II. ABSORPTION
6. HOW DRUGS REACH THEIR SITE OF ACTION 111
III. DISTRIBUTION
7. HOW THE ACTIONS OF DRUGS ARE TERMINATED 128
I. EẊCRETION
8. HOW THE ACTIONS OF DRUGS ARE TERMINATED 153
II. BIOTRANSFORMATION
9. GENERAL PRINCIPLES OF THE QUANTITATIVE ASPECTS OF 186
DRUG ACTION
I. DOSE-RESPONSE RELATIONSHIPS
10. GENERAL PRINCIPLES OF THE QUANTITATIVE ASPECTS OF 225
DRUG ACTION
II. TIME-RESPONSE RELATIONSHIPS
11. FACTORS MODIFYING THE EFFECTS OF DRUGS IN 266
INDIVIDUALS
I. VARIABILITY IN RESPONSE ATTRIBUTABLE TO THE
BIOLOGIC SYSTEM
12. FACTORS MODIFYING THE EFFECTS OF DRUGS IN 294
INDIVIDUALS
II. VARIABILITY IN RESPONSE ATTRIBUTABLE TO THE
CONDITIONS OF ADMINISTRATION