ONS/ONCC Chemotherapy & Immunotherapy Certification 2025/2026 – 100+ Verified Exam Questions | Myeloid vs Lymphoid, Immune Response, Chemo Agents, p53, Alkylating, Platinum, Antitumor Antibiotics | Oncology Nursing

This document offers 100+ fully verified and up-to-date exam questions with correct answers, tailored to the 2025/2026 ONS/ONCC Chemotherapy and Immunotherapy Certification Exam. It serves as a complete review guide for oncology nurses and healthcare professionals preparing for certification in safe and effective cancer treatment practices, including cellular biology, pharmacology, immunology, and chemotherapy safety protocols. Major topic areas include: Hematopoiesis & Lineages: myeloid vs lymphoid precursors, granulocytes, agranulocytes Innate vs Adaptive Immunity: first line of defense, immune memory, T-cell subtypes (cytotoxic, helper, regulatory), cytokine functions Tumor Biology: proto-oncogenes vs oncogenes, tumor suppressor genes (p53), DNA damage response Chemotherapy Mechanisms: Alkylating agents (e.g. Cytoxan, Ifosfamide) – DNA helix disruption Platinum compounds (cisplatin, carboplatin) – comparison with alkylating agents Antimetabolites – GI toxicity, hand-foot syndrome, myelosuppression Antitumor antibiotics – lifetime dose risks, cardiotoxicity (e.g. doxorubicin), pulmonary fibrosis (bleomycin) Plant alkaloids – examples include paclitaxel, vinblastine, docetaxel Adjuvant & Neoadjuvant Therapy: timing and rationale in treatment sequencing Immunotherapy and Biological Agents: cytotoxic responses, monoclonal antibody targeting ANC Calculation: WBC count formula and interpretation Patient Education: cold sensitivity post-oxaliplatin, lifetime dose precautions, anaphylaxis risk in lymphoma This file is particularly valuable for: Oncology nurses preparing for ONS/ONCC certification Chemotherapy-certified RNs and APRNs New grad nurses entering oncology units Students in oncology-focused NP, BSN, or MSN programs Clinical educators seeking pre-made assessments or study resources Keywords: ONS, ONCC, chemotherapy certification, immunotherapy, oncology nurse, p53 gene, proto-oncogene, alkylating agents, platinum drugs, antitumor antibiotics, ANC calculation, myeloid vs lymphoid, tumor suppressor, antimetabolites, oncology pharmacology