CURRENT Medical Diagnosis and
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
Ch. 1 — Disease Prevention & Health Promotion —
Immunizations
1. A 68-year-old man with well-controlled chronic obstructive
pulmonary disease (COPD) asks which vaccine will most
reduce his risk of severe influenza complications this
season. He has no prior egg allergy. Which is the best
choice?
, A. Live attenuated intranasal influenza vaccine (LAIV)
B. High-dose inactivated influenza vaccine (IIV-HD)
C. Standard-dose inactivated influenza vaccine (IIV-SD)
D. Recombinant zoster vaccine (RZV)
Correct Answer: B
Rationales:
• B (correct): CMDT emphasizes that adults ≥65 benefit most
from high-dose or adjuvanted influenza vaccines to
improve immune response and reduce severe outcomes.
accessmedicine.mhmedical.com
• A: Live attenuated intranasal vaccine is contraindicated in
older adults and those with chronic pulmonary disease.
• C: Standard dose gives less immunogenicity in adults ≥65
compared with high-dose formulations.
• D: Recombinant zoster vaccine prevents shingles but does
not reduce influenza risk.
Teaching point: High-dose influenza vaccine is preferred for
adults ≥65 to boost protection.
Citation: Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1 — Immunizations.
accessmedicine.mhmedical.com
Ch. 1 — Disease Prevention & Health Promotion — Tobacco &
Behavioral Counseling
, 2. A 55-year-old woman with coronary artery disease wants
to quit smoking. She prefers medication over counseling
alone. Which first-line pharmacotherapy best aligns with
CMDT guidance for highest quit rates?
A. Nicotine replacement therapy (patch) alone
B. Bupropion sustained-release
C. Varenicline
D. Nortriptyline
Correct Answer: C
Rationales:
• C (correct): CMDT lists varenicline as first-line
pharmacotherapy with superior quit rates compared with
single NRT or bupropion for many patients.
accessmedicine.mhmedical.com
• A: Patch (NRT) is effective but generally less effective than
varenicline when used alone.
• B: Bupropion is first-line but typically slightly less effective
than varenicline for many patients.
• D: Nortriptyline is a second-line option; not first-line per
CMDT.
Teaching point: Varenicline commonly yields higher cessation
rates than single NRT or bupropion.
Citation: Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1 — Tobacco Cessation.
accessmedicine.mhmedical.com
, Ch. 1 — Disease Prevention & Health Promotion — Adult
Screening & Preventive Services
3. A 46-year-old asymptomatic woman asks about routine
screening. She has no family history of breast cancer and
no prior abnormal mammograms. According to CMDT
screening recommendations, what is the most appropriate
mammography advice?
A. Begin annual screening now (age 46) and continue
annually.
B. No mammography until age 50 given low risk.
C. Shared decision-making; consider starting screening
between 40–49.
D. Only perform mammography if she develops breast
symptoms.
Correct Answer: C
Rationales:
• C (correct): CMDT emphasizes that women aged 40–49
should engage in shared decision-making about screening,
considering benefits/harms and patient values.
accessmedicine.mhmedical.com
• A: Automatic annual screening from 40 without discussion
is not uniformly recommended; patient preference
matters.
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
Ch. 1 — Disease Prevention & Health Promotion —
Immunizations
1. A 68-year-old man with well-controlled chronic obstructive
pulmonary disease (COPD) asks which vaccine will most
reduce his risk of severe influenza complications this
season. He has no prior egg allergy. Which is the best
choice?
, A. Live attenuated intranasal influenza vaccine (LAIV)
B. High-dose inactivated influenza vaccine (IIV-HD)
C. Standard-dose inactivated influenza vaccine (IIV-SD)
D. Recombinant zoster vaccine (RZV)
Correct Answer: B
Rationales:
• B (correct): CMDT emphasizes that adults ≥65 benefit most
from high-dose or adjuvanted influenza vaccines to
improve immune response and reduce severe outcomes.
accessmedicine.mhmedical.com
• A: Live attenuated intranasal vaccine is contraindicated in
older adults and those with chronic pulmonary disease.
• C: Standard dose gives less immunogenicity in adults ≥65
compared with high-dose formulations.
• D: Recombinant zoster vaccine prevents shingles but does
not reduce influenza risk.
Teaching point: High-dose influenza vaccine is preferred for
adults ≥65 to boost protection.
Citation: Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1 — Immunizations.
accessmedicine.mhmedical.com
Ch. 1 — Disease Prevention & Health Promotion — Tobacco &
Behavioral Counseling
, 2. A 55-year-old woman with coronary artery disease wants
to quit smoking. She prefers medication over counseling
alone. Which first-line pharmacotherapy best aligns with
CMDT guidance for highest quit rates?
A. Nicotine replacement therapy (patch) alone
B. Bupropion sustained-release
C. Varenicline
D. Nortriptyline
Correct Answer: C
Rationales:
• C (correct): CMDT lists varenicline as first-line
pharmacotherapy with superior quit rates compared with
single NRT or bupropion for many patients.
accessmedicine.mhmedical.com
• A: Patch (NRT) is effective but generally less effective than
varenicline when used alone.
• B: Bupropion is first-line but typically slightly less effective
than varenicline for many patients.
• D: Nortriptyline is a second-line option; not first-line per
CMDT.
Teaching point: Varenicline commonly yields higher cessation
rates than single NRT or bupropion.
Citation: Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1 — Tobacco Cessation.
accessmedicine.mhmedical.com
, Ch. 1 — Disease Prevention & Health Promotion — Adult
Screening & Preventive Services
3. A 46-year-old asymptomatic woman asks about routine
screening. She has no family history of breast cancer and
no prior abnormal mammograms. According to CMDT
screening recommendations, what is the most appropriate
mammography advice?
A. Begin annual screening now (age 46) and continue
annually.
B. No mammography until age 50 given low risk.
C. Shared decision-making; consider starting screening
between 40–49.
D. Only perform mammography if she develops breast
symptoms.
Correct Answer: C
Rationales:
• C (correct): CMDT emphasizes that women aged 40–49
should engage in shared decision-making about screening,
considering benefits/harms and patient values.
accessmedicine.mhmedical.com
• A: Automatic annual screening from 40 without discussion
is not uniformly recommended; patient preference
matters.
