APEA MyQ Bank - Principles of Pharmacology Exam Questions
AND Correct Answers
A chemical synapse differs from an electrical synapse in that
the signal transmission:
A. is rapid
B. requires a neurotransmitter
C. is a passive process
D. can occur in both directions - ✔✔B. requires a
neurotransmitter
Acetylcholine works at the neuromuscular junction to active:
A. an emotional response
B. smooth muscles
C. the digestive process
D. skeletal muscles - ✔✔D. skeletal muscles
Activation of alpha-1 receptors does NOT:
A. cause vasoconstriction
,B. cause mydriasis
C. increase closure of the internal bladder sphincter
D. inhibit insulin release - ✔✔D. inhibit insulin release
Alpha-1 receptors primarily mediate smooth muscle
constriction (vasoconstriction, mydriasis, closure of internal
bladder sphincter, secretion from salivary and sweat glands,
sodium reabsorption from kidneys, contraction of urinary
bladder)
After a drug is metabolized by the liver and enters the bile, it
is most likely to be: - ✔✔fecally excreted
Urinary excretion, on the other hand, is the usual route of
elimination for LMW drugs that are not metabolized and are
sufficiently water-soluble to avoid reabsorption from the
renal tubule
Correct sequence of movement of drug through the body: -
✔✔absorption, distribution, metabolism, excretion
Distribution of a drug is determined by the:
, A. amount of drug entering circulation
B. proportion of drug removed from circulation
C. chemical alteration of a drug to a water-soluble state
D. reversible transfer of a drug from one location to another
within the body - ✔✔D. the reversible transfer of a drug from
one location to another within the body.
Drug clearance formula - ✔✔rate of drug elimination / plasma
concentration of the drug
Drugs that accumulate in the tissues:
A. always cause toxicity
B. are prone to higher degrees of side effects
C. keep blood levels of drug from decreasing rapidly
D. must be administered at higher doses - ✔✔C. keep blood
levels of drug from decreasing rapidly
ex: digoxin accumulates in heart and skeletal muscles, which
can act as reservoirs of extra drug. These tissues slowly
release the drug into the bloodstream, keeping blood levels of
AND Correct Answers
A chemical synapse differs from an electrical synapse in that
the signal transmission:
A. is rapid
B. requires a neurotransmitter
C. is a passive process
D. can occur in both directions - ✔✔B. requires a
neurotransmitter
Acetylcholine works at the neuromuscular junction to active:
A. an emotional response
B. smooth muscles
C. the digestive process
D. skeletal muscles - ✔✔D. skeletal muscles
Activation of alpha-1 receptors does NOT:
A. cause vasoconstriction
,B. cause mydriasis
C. increase closure of the internal bladder sphincter
D. inhibit insulin release - ✔✔D. inhibit insulin release
Alpha-1 receptors primarily mediate smooth muscle
constriction (vasoconstriction, mydriasis, closure of internal
bladder sphincter, secretion from salivary and sweat glands,
sodium reabsorption from kidneys, contraction of urinary
bladder)
After a drug is metabolized by the liver and enters the bile, it
is most likely to be: - ✔✔fecally excreted
Urinary excretion, on the other hand, is the usual route of
elimination for LMW drugs that are not metabolized and are
sufficiently water-soluble to avoid reabsorption from the
renal tubule
Correct sequence of movement of drug through the body: -
✔✔absorption, distribution, metabolism, excretion
Distribution of a drug is determined by the:
, A. amount of drug entering circulation
B. proportion of drug removed from circulation
C. chemical alteration of a drug to a water-soluble state
D. reversible transfer of a drug from one location to another
within the body - ✔✔D. the reversible transfer of a drug from
one location to another within the body.
Drug clearance formula - ✔✔rate of drug elimination / plasma
concentration of the drug
Drugs that accumulate in the tissues:
A. always cause toxicity
B. are prone to higher degrees of side effects
C. keep blood levels of drug from decreasing rapidly
D. must be administered at higher doses - ✔✔C. keep blood
levels of drug from decreasing rapidly
ex: digoxin accumulates in heart and skeletal muscles, which
can act as reservoirs of extra drug. These tissues slowly
release the drug into the bloodstream, keeping blood levels of
