1. What is cirrhosis? end stage liver disease
2. What is the result of cirrhosis? replacement of liver tissue by fibrous and regenerative
nodules
3. What does cirrhosis usually hap- decades of chronic liver disease
pen after?
4. What is a major factor of cirrho- excessive alcohol
sis?
5. What is the most common cause -chronic hep C
of cirrhosis in the US? -excessive alchohol consumption
6. What is the basic pathophysiolo- liver inflammation progresses to necrosis which results in
gy of cirrhosis? fibrotic scarring
7. What does overgrowth of new fi- distorts its normal lobular structure to an irregular nodular
brous connective tissue do to the shape
liver?
8. What are the two stages of cir- -compensated
rhosis? -decompensated
9. Which stage of cirrhosis is early compensated
and less severe?
10. Which stage of cirrhosis is usual- compensated
ly asymptomatic?
11. Which stage of cirrhosis is late decompensated
and more sever?
12.
, What are some early symptoms -fatigue
of early stage cirrhosis? -enlarged liver
13. What will blood tests look like normal
with compensated cirrhosis?
14. What causes the start of decom- -liver failure
pensated cirrhosis? -portal HTN
15. What may be some late manifes- -jaundice
tations of cirrhosis? -peripheral edema
-ascites
16. What causes jaundice? liver is unable to conjugate and excrete bilirubin
17. What are some skin conditions -spider angiomas
seen with decompensated cir- -palmar erythema
rhosis?
18. What is a common finding in al- peripheral neuropathy (tingling and numbness in fingers)
coholic cirrhosis?
19. What is one of the main en- gynecomastia
docrine disorders seen in men
with decompensated cirrhosis?
20. What is one of the main amenorrhea
endocrine disorders seen in
women with decompensated cir-
rhosis?
21. What are the main complications -portal HTN
seen with decompensated cir- -esophageal and gastric varicosities
rhosis? -peripheral edema
, -abdominal ascites
-heaptic encephalopathy
-hepatorenal syndrome
22. What is portal HTN? increased venous pressure in portal circulation
23. What results from portal HTN? -splenomegaly
-large collateral veins
-ascites
-gastric and esophageal varices
24. What are the 2 types of varicosi- -esophageal
ties? -gastric
25. Where are esophageal varices Enlarged veins at lower end of the esophagus
found?
26. Where are gastric varices found? Dilated veins a by upper part of the stomach
27. Are varicosities strong? No, very fragile and bleed easily
28. What is the most life threatening Varicosities
complication of de compensated
cirrhosis?
29. What causes peripheral edema? Increased pressure from portal HTN
30. In which extremities will you see Lower
peripheral edema due to decom-
pensated cirrhosis?
31. Why will a patient have fluid vol- albumin loss
ume overload with de compen-
sated cirrhosis?