PCB 3233 Immunology Exam 4
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,1. Positive Selection
ANSWER makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
2. Negative Selection
ANSWER Makes sure it does not recognize your peptide
MHC too strongly
3. Does gamma
delta T-cells have to go through positive selection?
ANSWER No
4. What does turning off RAG 1&2 do to your gene rearrangement?
ANSWER Preserve the current rearrangement
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,5. Primary Lymphoid Tissue
ANSWER bone marrow and thymus
6. What does TH1 cells do?
ANSWER Activate macrophages
7. Thymal Stromal Cells
ANSWER Keeps BCR genes closed and opens TCR genes
8. IgM activates?
ANSWER complement
9. Notch-1
ANSWER The signal for survival. It drives the cell on the T-cell path — signals to open up T-cell rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
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, 10. Where does Maturation and Positive Selection occur?
ANSWER Cortex of the thymus
11. Can negative selection also take place in the Cortex?
ANSWER Yes, negative selection can take place in the cortex at the same time as positive selection
12. Where does negative selection take place?
ANSWER medulla of thymus
13. Where are mature thymocytes located?
ANSWER Medulla
14. Where are immature thymocytes located?
ANSWER Cortex
15. What special cells are in the Medulla
ANSWER Dendritic cells, macrophages, and medullary epithelial cells
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,1. Positive Selection
ANSWER makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
2. Negative Selection
ANSWER Makes sure it does not recognize your peptide
MHC too strongly
3. Does gamma
delta T-cells have to go through positive selection?
ANSWER No
4. What does turning off RAG 1&2 do to your gene rearrangement?
ANSWER Preserve the current rearrangement
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39
,5. Primary Lymphoid Tissue
ANSWER bone marrow and thymus
6. What does TH1 cells do?
ANSWER Activate macrophages
7. Thymal Stromal Cells
ANSWER Keeps BCR genes closed and opens TCR genes
8. IgM activates?
ANSWER complement
9. Notch-1
ANSWER The signal for survival. It drives the cell on the T-cell path — signals to open up T-cell rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
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, 10. Where does Maturation and Positive Selection occur?
ANSWER Cortex of the thymus
11. Can negative selection also take place in the Cortex?
ANSWER Yes, negative selection can take place in the cortex at the same time as positive selection
12. Where does negative selection take place?
ANSWER medulla of thymus
13. Where are mature thymocytes located?
ANSWER Medulla
14. Where are immature thymocytes located?
ANSWER Cortex
15. What special cells are in the Medulla
ANSWER Dendritic cells, macrophages, and medullary epithelial cells
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