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ANCC Practice Questions | Verified Questions and Correct Answers | 100% Accurate & Updated | 2025–2026 Edition | GET FULLY PREPARED WITH

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GET FULLY PREPARED WITH this ANCC Practice Questions guide, featuring verified and 100% correct answers from the latest 2025–2026 edition. This comprehensive resource covers all core ANCC exam domains, including clinical decision-making, pharmacology, patient safety, ethical and legal considerations, and professional practice. Designed for nurse practitioners and registered nurses, it ensures complete readiness for certification with clear, evidence-based explanations and realistic exam-style questions.

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ANCC Practice
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ANCC Practice

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Uploaded on
October 29, 2025
Number of pages
64
Written in
2025/2026
Type
Exam (elaborations)
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Questions & answers

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Page |1


ANCC Practice Questions Questions and
Correct Answers/ Latest Update / Already
Graded
A 46 year old male with a history of bipolar disorder comes for a
regular follow up appointment with a PMHNP and presents with
complaints of severe vomiting, diarrhea, muscle weakness, blurred
vision, and ataxia. The patient is currently taking 900 mg of lithium
daily. The psychiatric nurse practitioner identifies these symptoms as
signs of lithium toxicity. What is the priority action of the PMHNP?



A. Maintains medication regimen and monitors the symptoms.

B. Tells the patient to stop taking lithium in orders of serum lithium
level.

C. Order an electrocardiogram.

D. Take the patient's vital signs.

Ans: B. Tells the patient to stop taking lithium in orders of
serum lithium level.


For 12 years, a 65 year old patient with bipolar affective disorder has
been treated with lithium 900 mg daily. When oral hydrochlorothiazide
12.5 mg daily is added for hypertension, the patient develops nausea,
vomiting, ataxia, and muscle weakness, and the patient's serum



All rights reserved © 2025/ 2026 |

, Page |2

lithium level is 2.0 the interaction of the lithium and thiazide diuretic
has induced:



A. Hypokalemia.

B. Hyponatremia.

C. Increased Renal clearance of lithium.

D. Reduced renal clearance of lithium.

Ans: D. Reduced renal clearance of lithium


Mary, a 45-year-old African-American female has been treated on
isocarboxazid (Marplan) for over six years. Mari is going in for a surgical
procedure. Which medication is strictly contraindicated with
isocarboxazid?



A. Morphine.

B. NSAIDs.

C. Methylphenidate.

D. Acetaminophen.

Ans: C. Methylphenidate




All rights reserved © 2025/ 2026 |

, Page |3

The psychiatric mental health nurse practitioner is aware of the
following signs to watch out for in patients taking clozapine (clozaril)



A. Nosebleeds, bleeding gums, and skin rash

B. Mutism, muscle rigidity, and hyperthermia

C. Fever, sore throat, and chills

D. Ataxia, confusion, hypothyroidism

Ans: C. Fever, sore throat, and chills


A new prescription of carbamazepine is given to a patient who is
baseline white blood cell count is 5000 an absolute neutrophil count is
4000. Laboratory test show that the patient WBC count has decreased
to 2500 and ANC has decreased to 750 after two weeks of therapy.
Similar outcomes are obtained when the laboratory studies are
repeated. The patient is not present with any signs of infection. What is
the next action of the PMHNP?



A. Continues a patient on Tegretol and monitor the patient for signs of
infection.

B. Tell the patient to stop taking Tegretol and recheck the ANC and
WBC.




All rights reserved © 2025/ 2026 |

, Page |4

C. Continues the patient on Tegretol since the WBC is within normal
limits.

D. Refer the patient to a primary care provider.

Ans: B. Tell the patient to stop taking Tegretol and recheck the
ANC and WBC


If given during pregnancy sodium valproate (depakote) can cause
which of the following medical problems in the baby?



A. Steven Johnson syndrome

B. Ebstein's anomaly

C. Spina bifida

D. Cleft palate

Ans: C. Spina bifida


Which mood stabilizer is associated with potential life threatening rash
in the Asian population?



A. Carbamazepine (tegretol)

B. Depakote

C. Lithium

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