ACOG Practice Bulletin 226 UPDATED
ACTUAL Questions and CORRECT
Answers
True or False: Pretest and post- test counseling are essential and must be a part of any screening
program. - CORRECT ANSWER - True
What is aneuploidy? - CORRECT ANSWER - Having one or more extra or missing
chromosomes
How common are chromosomal abnormalities in live births? - CORRECT ANSWER -
1/150 live births are affected with a chromosome abnormality
Name three factors that increase the chance for a chromosome abnormality - CORRECT
ANSWER - 1. Maternal Age
2. Previous pregnancy affected with a chromosome abnormality
3. Ultrasound abnormalities
Do ACOG practice guidelines dictate an exclusive course of treatment? - CORRECT
ANSWER - No
The information is designed to aid practitioners in making decisions about appropriate obstetric
and gynecologic care. Variations in practice may be warranted based on the needs of the
individual patient, resources, and limitations unique to the institution or type of practice.
What is the most common autosomal trisomy? - CORRECT ANSWER - Trisomy 21
(Down syndrome)
What is the most common sex chromosome abnormality? - CORRECT ANSWER - 47,
XXY Klinefelter syndrome
, How common is Klinefelter syndrome? - CORRECT ANSWER - 1/500 males are
affected or 1/1,000 births
What is the only viable monosomy? - CORRECT ANSWER - Turner syndrome (45, X)
What percentage of cases of Down syndrome are caused by non-disjunction? - CORRECT
ANSWER - 95%
What is the median survival of individuals affected with Down syndrome in economically
developed countries? - CORRECT ANSWER - Approximately 60 years of age
What percentage of pregnancies affected with Down syndrome end in miscarriage or stillbirth? -
CORRECT ANSWER - 43%
Does ACOG discourage women who have a negative screening test for aneuploidy from having
a procedure such as amnio or CVS so that diagnostic testing such as microarray or chromosome
analysis can be performed - CORRECT ANSWER - No, even if a woman has had
negative aneuploidy screening ACOG supports the option of diagnostic testing should that
patient want it
Who does ACOG recommend should be offered the option of diagnostic testing as well as
aneuploidy screening and when? - CORRECT ANSWER - All women regardless of their
age should be offered screening and diagnostic testing early in pregnancy
What percentage of pregnancies affected with Down syndrome occur in women 35 or older at
the time of delivery? - CORRECT ANSWER - Approximately 22% (21.6%)
What is nondisjunction? - CORRECT ANSWER - Nondisjunction is the failure of
homologous chromosomes or sister chromatids to separate subsequent to metaphase in meiosis
or mitosis so that one daughter cell has both and the other neither of the chromosomes.
ACTUAL Questions and CORRECT
Answers
True or False: Pretest and post- test counseling are essential and must be a part of any screening
program. - CORRECT ANSWER - True
What is aneuploidy? - CORRECT ANSWER - Having one or more extra or missing
chromosomes
How common are chromosomal abnormalities in live births? - CORRECT ANSWER -
1/150 live births are affected with a chromosome abnormality
Name three factors that increase the chance for a chromosome abnormality - CORRECT
ANSWER - 1. Maternal Age
2. Previous pregnancy affected with a chromosome abnormality
3. Ultrasound abnormalities
Do ACOG practice guidelines dictate an exclusive course of treatment? - CORRECT
ANSWER - No
The information is designed to aid practitioners in making decisions about appropriate obstetric
and gynecologic care. Variations in practice may be warranted based on the needs of the
individual patient, resources, and limitations unique to the institution or type of practice.
What is the most common autosomal trisomy? - CORRECT ANSWER - Trisomy 21
(Down syndrome)
What is the most common sex chromosome abnormality? - CORRECT ANSWER - 47,
XXY Klinefelter syndrome
, How common is Klinefelter syndrome? - CORRECT ANSWER - 1/500 males are
affected or 1/1,000 births
What is the only viable monosomy? - CORRECT ANSWER - Turner syndrome (45, X)
What percentage of cases of Down syndrome are caused by non-disjunction? - CORRECT
ANSWER - 95%
What is the median survival of individuals affected with Down syndrome in economically
developed countries? - CORRECT ANSWER - Approximately 60 years of age
What percentage of pregnancies affected with Down syndrome end in miscarriage or stillbirth? -
CORRECT ANSWER - 43%
Does ACOG discourage women who have a negative screening test for aneuploidy from having
a procedure such as amnio or CVS so that diagnostic testing such as microarray or chromosome
analysis can be performed - CORRECT ANSWER - No, even if a woman has had
negative aneuploidy screening ACOG supports the option of diagnostic testing should that
patient want it
Who does ACOG recommend should be offered the option of diagnostic testing as well as
aneuploidy screening and when? - CORRECT ANSWER - All women regardless of their
age should be offered screening and diagnostic testing early in pregnancy
What percentage of pregnancies affected with Down syndrome occur in women 35 or older at
the time of delivery? - CORRECT ANSWER - Approximately 22% (21.6%)
What is nondisjunction? - CORRECT ANSWER - Nondisjunction is the failure of
homologous chromosomes or sister chromatids to separate subsequent to metaphase in meiosis
or mitosis so that one daughter cell has both and the other neither of the chromosomes.
