NAPLEX EASY EXAM QUESTIONS
WITH 100% CORRECT ANSWERS |
LATEST VERSION 2025/2026.
Which of the following is best to avoid in overweight/obese patients due to the side effect of
weight gain?
A) Depo-Provera
B) NuvaRing
C) Ortho Evra
D) YAZ - ANS A
A 68-year-old man with recently diagnosed adenocarcinoma of the lung is found to have stage
IV disease (liver metastases). At home, he is bedridden due to severe COPD that requires home
oxygen. His social history is significant for an 80-pack year history. Which of the following
chemotherapy regimens, if any, would be rational?
A) Cisplatin plus etoposide
B) Carboplatin plus paclitaxel
C) Cisplatin plus gemcitabine
D) Best supportive care - ANS D
VG is a 57-year-old Caucasian man who reports to his primary care physician complaining of a
2-week history of fatigue and fever. A CBC with differential reveals an elevated WBC (50,000
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
,U/L) and profound thrombocytopenia (platelets 30,000 U/L). The patient is diagnosed with
acute myeloid leukemia (AML-M5).
A physician asks you about tumor lysis syndrome (TLS) prevention and management for patient
VG. Which of the following management recommendations would you make? Select ALL that
apply.
A) Initiating allopurinol
B) Treating electrolyte disturbances
C) Aggressive hydration
D) Colchcine - ANS A, B and C
A 26-year old male presents with polyuria and polyphagia and extreme fatigue over the last few
months. His primary care physician tests his Hemoglobin A1C which is 8.7% and diagnoses him
with Type II diabetes mellitus. Along with diet and exercise education, his physician places him
on metformin therapy.
Which of the following is a black box warning associated with metformin?
A) Subarachnoid hemorrhage
B) Lactic acidosis
C) Acute kidney injury
D) Agranulocytosis - ANS B
RQ is a 37-year-old woman attempting to become pregnant. Her physician decides that the
benefits of hyperlipidemia treatment outweigh fetal risks. Her LDL-C is 223 mg/dL, HDL-C 51 is
mg/dL, and TG is 139 mg/dL. Her PMH includes recent cholelithiasis. What is the most
appropriate medication for RQ?
A) Simvastatin
B) Niacin
C) Colesevelam
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
,D) Gemfibrozil - ANS C
The student pharmacist performed a two-compartment model for dosing of LR's theophylline.
The student predicted the theophylline concentration to be 10 mg/L; however, after a serum
sample was obtained and analyzed, the theophylline concentration was 25 mg/L. What
parameters could affect theophylline's clearance that would account for the error in
calculation? Select ALL that apply.
A) Smoking history
B) Hepatic cirrhosis
C) Drug interactions (cytochrome P-450 inhibitors especially especially 1A2, 2E1, 3A4)
D) Renal failure - ANS A, B and C
In what patient(s) may a Haemophilus influenzae type b (Hib) vaccine be administered? Select
ALL that apply.
A) A 4-month old infant
B) A 20-year-old smoker
C) A 58-year-old man with leukemia
D) A 26-year-old with asplenia - ANS A, C and D
Which of the following antiretrovirals should be used with caution in patients with a sulfa
allergy? Select ALL that apply.
A) Fosamprenavir
B) Tipranavir
C) Darunavir
D) Indinavir - ANS A, B and C
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
, CR is a 52-year-old man diagnosed with chronic hepatitis C (HCV) genotype 1. Today, he will
begin peg-interferon alpha-2b and ribavirin therapy. Which of the following counseling topics is
appropriate?
A) CR should use 2 forms of birth control
B) CR's therapy will last 24 weeks
C) CR likely developed HCV from a contaminated food source
D) CR likely acquired HCV from perinatal transmission - ANS A
Preparedness is achieved and maintained by which of the following? Select ALL that apply.
A) Planning
B) Organizing
C) Training
D) Exercising - ANS A, B, C and D
VT is a 28-year-old man with stage IV metastatic melanoma, who is receiving biochemotherapy
treatment with cisplatin, vinblastine, dacarbazine, interferon-alfa 2b, and interleukin-2. His
laboratory values prior to treatment are within normal limits. Which of the following is a
supportive care management option for VT's biochemotherapy treatment that you would
recommend? Select ALL that apply.
A) Premedication with acetaminophen
B) Premedication with dolasetron and dexamethasone
C) Premedication with 0.25 mg IV push
D) Premedication with naloxone - ANS A and B
A patient presents to your pharmacy to ask a question about influenza symptom resolution. She
was diagnosed with influenza B. She still has cough and malaise. What should you discuss with
the patient?
4 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
WITH 100% CORRECT ANSWERS |
LATEST VERSION 2025/2026.
Which of the following is best to avoid in overweight/obese patients due to the side effect of
weight gain?
A) Depo-Provera
B) NuvaRing
C) Ortho Evra
D) YAZ - ANS A
A 68-year-old man with recently diagnosed adenocarcinoma of the lung is found to have stage
IV disease (liver metastases). At home, he is bedridden due to severe COPD that requires home
oxygen. His social history is significant for an 80-pack year history. Which of the following
chemotherapy regimens, if any, would be rational?
A) Cisplatin plus etoposide
B) Carboplatin plus paclitaxel
C) Cisplatin plus gemcitabine
D) Best supportive care - ANS D
VG is a 57-year-old Caucasian man who reports to his primary care physician complaining of a
2-week history of fatigue and fever. A CBC with differential reveals an elevated WBC (50,000
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
,U/L) and profound thrombocytopenia (platelets 30,000 U/L). The patient is diagnosed with
acute myeloid leukemia (AML-M5).
A physician asks you about tumor lysis syndrome (TLS) prevention and management for patient
VG. Which of the following management recommendations would you make? Select ALL that
apply.
A) Initiating allopurinol
B) Treating electrolyte disturbances
C) Aggressive hydration
D) Colchcine - ANS A, B and C
A 26-year old male presents with polyuria and polyphagia and extreme fatigue over the last few
months. His primary care physician tests his Hemoglobin A1C which is 8.7% and diagnoses him
with Type II diabetes mellitus. Along with diet and exercise education, his physician places him
on metformin therapy.
Which of the following is a black box warning associated with metformin?
A) Subarachnoid hemorrhage
B) Lactic acidosis
C) Acute kidney injury
D) Agranulocytosis - ANS B
RQ is a 37-year-old woman attempting to become pregnant. Her physician decides that the
benefits of hyperlipidemia treatment outweigh fetal risks. Her LDL-C is 223 mg/dL, HDL-C 51 is
mg/dL, and TG is 139 mg/dL. Her PMH includes recent cholelithiasis. What is the most
appropriate medication for RQ?
A) Simvastatin
B) Niacin
C) Colesevelam
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
,D) Gemfibrozil - ANS C
The student pharmacist performed a two-compartment model for dosing of LR's theophylline.
The student predicted the theophylline concentration to be 10 mg/L; however, after a serum
sample was obtained and analyzed, the theophylline concentration was 25 mg/L. What
parameters could affect theophylline's clearance that would account for the error in
calculation? Select ALL that apply.
A) Smoking history
B) Hepatic cirrhosis
C) Drug interactions (cytochrome P-450 inhibitors especially especially 1A2, 2E1, 3A4)
D) Renal failure - ANS A, B and C
In what patient(s) may a Haemophilus influenzae type b (Hib) vaccine be administered? Select
ALL that apply.
A) A 4-month old infant
B) A 20-year-old smoker
C) A 58-year-old man with leukemia
D) A 26-year-old with asplenia - ANS A, C and D
Which of the following antiretrovirals should be used with caution in patients with a sulfa
allergy? Select ALL that apply.
A) Fosamprenavir
B) Tipranavir
C) Darunavir
D) Indinavir - ANS A, B and C
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
, CR is a 52-year-old man diagnosed with chronic hepatitis C (HCV) genotype 1. Today, he will
begin peg-interferon alpha-2b and ribavirin therapy. Which of the following counseling topics is
appropriate?
A) CR should use 2 forms of birth control
B) CR's therapy will last 24 weeks
C) CR likely developed HCV from a contaminated food source
D) CR likely acquired HCV from perinatal transmission - ANS A
Preparedness is achieved and maintained by which of the following? Select ALL that apply.
A) Planning
B) Organizing
C) Training
D) Exercising - ANS A, B, C and D
VT is a 28-year-old man with stage IV metastatic melanoma, who is receiving biochemotherapy
treatment with cisplatin, vinblastine, dacarbazine, interferon-alfa 2b, and interleukin-2. His
laboratory values prior to treatment are within normal limits. Which of the following is a
supportive care management option for VT's biochemotherapy treatment that you would
recommend? Select ALL that apply.
A) Premedication with acetaminophen
B) Premedication with dolasetron and dexamethasone
C) Premedication with 0.25 mg IV push
D) Premedication with naloxone - ANS A and B
A patient presents to your pharmacy to ask a question about influenza symptom resolution. She
was diagnosed with influenza B. She still has cough and malaise. What should you discuss with
the patient?
4 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
