UMKC SOP Pharmaceutics Exam 1's Questions With Complete Solutions
Leptin is a hormone whose role is involved with fat metabolism. - (ANSWER)True
When working with biological safety cabinets, manipulations should be performed at least 6 inches from
each wall from the horizontal plane. - (ANSWER)False
ID route is particularly susceptible to irritation. - (ANSWER)False
Pyrogen is insoluble in water and thermolabile, so may remain in water even after sterilization. -
(ANSWER)False
Lantus® insulin is administered "subcutaneously" with either Lantus® pen or a syringe. - (ANSWER)True
Concentration < 0.2 % of sulfur oxide equivalent amount can be used to maintain the stability of
parenteral formulations. - (ANSWER)True
The Limulus Amebocyte Lysate (LAL) test is an in vitro pyrogen test that is more reliable and more
sensitive to bacterial endotoxins than the rabbit pyrogenic test. - (ANSWER)True
In thermal sterilization, the objects to be sterilized are exposed to saturated steam under pressure at
121oC for at least 2 hrs. - (ANSWER)False
To prevent degradation of drug by oxidation, antioxidant, either alone or in combination with chelating
agents can be used. - (ANSWER)True
Polyethylene glycol acts as a stabilizer in parenteral products. - (ANSWER)False
In quality control of 'particulate matter', the USP standards are met if the SVP's under test contain no
more than 10,000 particles of 10 µm per container, and no more than 1000 particles of 25 µm in an
effective spherical diameter per container. - (ANSWER)True
Levigation is the process of grinding an insoluble drug/substance to a fine powder/solid, while wet, in
the ointment preparation process - (ANSWER)True
,UMKC SOP Pharmaceutics Exam 1's Questions With Complete Solutions
Both 'halogenated phenols' and 'benzoic acid' (as ointment preservatives) have 'objectional odor'. -
(ANSWER)False
Most of antibiotics are unstable in the presence of moisture, so 'Hydrophilic Petrolatum' is suitable for
their ointment base. - (ANSWER)True
The mEq weight of Magnesium Sulfate (MW are 24 (Mg) and 96 (SO4)) is 120 mEq. (HW #4) -
(ANSWER)False
Amphotericin B Injection is a suitable formulation for IT route injection without any further
manipulation. - (ANSWER)True
Chemicals (Gas) sterilization is the preferred method for pharmaceutical products containing heat-
sensitive enzyme preparations and certain antibiotics. - (ANSWER)True
Polyethylene glycol ointment base has 'occlusion property'. - (ANSWER)False
Which of the following is not a proper property related with TPN?
a. It generally has a large volume (>100 ml)
b. It is used for multiple drug therapy and vital organ support.
c. Fatty acids are included because they help keep blood from clotting, lower cholesterol, and help
prevent cancer cell growth.
d. It has about 1300-1800 mOsmol/kg.
e. all of the above are proper properties of TPN - (ANSWER)E. all of the above are proper properties of
TPN
Which of the following statements is not correct?
a. Only aqueous preparations are acceptable for the intraarticular Route.
,UMKC SOP Pharmaceutics Exam 1's Questions With Complete Solutions
b. Pore size 0.22 um is used for removal of 'microbes' in a filtration method.
c. The optimal volume range of intrathecal rout is 0.1~0.5 ml.
d. Polysorbate 80 can be used as a wetting agent for parenteral formulations.
e. The gauge number of needles for Sub Q route is usually smaller than that for ID route - (ANSWER)A.
some preparations other than aqueous are acceptable for the intraarticular Route.
Which of the following statements is not 'true' statement for the cytotoxic drugs?
a. The cytotoxic drugs should be identified by distinctive labels indicating special handling requirements.
b. The cytotoxic drugs should be kept at eye level or lower and always stored in bins.
c. Storage shelves for the cytotoxic drugs don't need front barriers.
d. Should leakage or breakage of the cytotoxic drugs occur, special procedure for cleanup should be
followed.
e. All of above are true statements. - (ANSWER)C. Storage shelves for the cytotoxic drugs Need front
barriers.
Which of the following ions are present in the intracellular compartment which accounts for at least
10% of the total ions (i.e. 388)?
a. chloride
b. sodium
c. bicarbonate
d. potassium
e. c and d - (ANSWER)D. potassium
Which of the following sterilization methods can be used to sterilize extemporaneous preparations?
a. steam sterilization
b. dry heat sterilization
c. gas sterilization
, UMKC SOP Pharmaceutics Exam 1's Questions With Complete Solutions
d. filtration
e. radiation sterilization - (ANSWER)D. filtration
Which one is categorized as physical incompatibility?
a. Calcium and Phosphate salts
b. penicillin buffered at an acidic pH (<3.5)
c. penicillin and tetracycline
d. Probably cause the most toxic results among 3 types of incompatibilities
e None of the above - (ANSWER)A. Calcium and Phosphate salts
Which of the following is not a correct statement for handling of cytotoxic drugs?
a. The cytotoxic drugs should be prepared in "Class II" biological safety cabinets (BSC)
b. Isolators do not need a clean room, but are more robust and immune to environmental disturbance
c. A vertical laminar hood should be used during drug preparation, with exhaust directed outside.
d. To equalize the pressure in syringe, hydrophilic filter venting unit should be used.
e. All of the above are correct statements. - (ANSWER)D. is incorrect
Which of the following is not a correct statement regarding sorbate?
a) It must be used at pH <6.5 to 7.
b) High concentrations of sorbate are oxidized by sunlight.
c) It has limited antibacterial activity.
d) It is used as an ointment preservative.
e) All of the above are characteristics of sorbate. - (ANSWER)E. All of the above are characteristics of
sorbate.
Which of the following is not a property related with the following formulation?
Leptin is a hormone whose role is involved with fat metabolism. - (ANSWER)True
When working with biological safety cabinets, manipulations should be performed at least 6 inches from
each wall from the horizontal plane. - (ANSWER)False
ID route is particularly susceptible to irritation. - (ANSWER)False
Pyrogen is insoluble in water and thermolabile, so may remain in water even after sterilization. -
(ANSWER)False
Lantus® insulin is administered "subcutaneously" with either Lantus® pen or a syringe. - (ANSWER)True
Concentration < 0.2 % of sulfur oxide equivalent amount can be used to maintain the stability of
parenteral formulations. - (ANSWER)True
The Limulus Amebocyte Lysate (LAL) test is an in vitro pyrogen test that is more reliable and more
sensitive to bacterial endotoxins than the rabbit pyrogenic test. - (ANSWER)True
In thermal sterilization, the objects to be sterilized are exposed to saturated steam under pressure at
121oC for at least 2 hrs. - (ANSWER)False
To prevent degradation of drug by oxidation, antioxidant, either alone or in combination with chelating
agents can be used. - (ANSWER)True
Polyethylene glycol acts as a stabilizer in parenteral products. - (ANSWER)False
In quality control of 'particulate matter', the USP standards are met if the SVP's under test contain no
more than 10,000 particles of 10 µm per container, and no more than 1000 particles of 25 µm in an
effective spherical diameter per container. - (ANSWER)True
Levigation is the process of grinding an insoluble drug/substance to a fine powder/solid, while wet, in
the ointment preparation process - (ANSWER)True
,UMKC SOP Pharmaceutics Exam 1's Questions With Complete Solutions
Both 'halogenated phenols' and 'benzoic acid' (as ointment preservatives) have 'objectional odor'. -
(ANSWER)False
Most of antibiotics are unstable in the presence of moisture, so 'Hydrophilic Petrolatum' is suitable for
their ointment base. - (ANSWER)True
The mEq weight of Magnesium Sulfate (MW are 24 (Mg) and 96 (SO4)) is 120 mEq. (HW #4) -
(ANSWER)False
Amphotericin B Injection is a suitable formulation for IT route injection without any further
manipulation. - (ANSWER)True
Chemicals (Gas) sterilization is the preferred method for pharmaceutical products containing heat-
sensitive enzyme preparations and certain antibiotics. - (ANSWER)True
Polyethylene glycol ointment base has 'occlusion property'. - (ANSWER)False
Which of the following is not a proper property related with TPN?
a. It generally has a large volume (>100 ml)
b. It is used for multiple drug therapy and vital organ support.
c. Fatty acids are included because they help keep blood from clotting, lower cholesterol, and help
prevent cancer cell growth.
d. It has about 1300-1800 mOsmol/kg.
e. all of the above are proper properties of TPN - (ANSWER)E. all of the above are proper properties of
TPN
Which of the following statements is not correct?
a. Only aqueous preparations are acceptable for the intraarticular Route.
,UMKC SOP Pharmaceutics Exam 1's Questions With Complete Solutions
b. Pore size 0.22 um is used for removal of 'microbes' in a filtration method.
c. The optimal volume range of intrathecal rout is 0.1~0.5 ml.
d. Polysorbate 80 can be used as a wetting agent for parenteral formulations.
e. The gauge number of needles for Sub Q route is usually smaller than that for ID route - (ANSWER)A.
some preparations other than aqueous are acceptable for the intraarticular Route.
Which of the following statements is not 'true' statement for the cytotoxic drugs?
a. The cytotoxic drugs should be identified by distinctive labels indicating special handling requirements.
b. The cytotoxic drugs should be kept at eye level or lower and always stored in bins.
c. Storage shelves for the cytotoxic drugs don't need front barriers.
d. Should leakage or breakage of the cytotoxic drugs occur, special procedure for cleanup should be
followed.
e. All of above are true statements. - (ANSWER)C. Storage shelves for the cytotoxic drugs Need front
barriers.
Which of the following ions are present in the intracellular compartment which accounts for at least
10% of the total ions (i.e. 388)?
a. chloride
b. sodium
c. bicarbonate
d. potassium
e. c and d - (ANSWER)D. potassium
Which of the following sterilization methods can be used to sterilize extemporaneous preparations?
a. steam sterilization
b. dry heat sterilization
c. gas sterilization
, UMKC SOP Pharmaceutics Exam 1's Questions With Complete Solutions
d. filtration
e. radiation sterilization - (ANSWER)D. filtration
Which one is categorized as physical incompatibility?
a. Calcium and Phosphate salts
b. penicillin buffered at an acidic pH (<3.5)
c. penicillin and tetracycline
d. Probably cause the most toxic results among 3 types of incompatibilities
e None of the above - (ANSWER)A. Calcium and Phosphate salts
Which of the following is not a correct statement for handling of cytotoxic drugs?
a. The cytotoxic drugs should be prepared in "Class II" biological safety cabinets (BSC)
b. Isolators do not need a clean room, but are more robust and immune to environmental disturbance
c. A vertical laminar hood should be used during drug preparation, with exhaust directed outside.
d. To equalize the pressure in syringe, hydrophilic filter venting unit should be used.
e. All of the above are correct statements. - (ANSWER)D. is incorrect
Which of the following is not a correct statement regarding sorbate?
a) It must be used at pH <6.5 to 7.
b) High concentrations of sorbate are oxidized by sunlight.
c) It has limited antibacterial activity.
d) It is used as an ointment preservative.
e) All of the above are characteristics of sorbate. - (ANSWER)E. All of the above are characteristics of
sorbate.
Which of the following is not a property related with the following formulation?
