BMSC 200 MIDTERM 1 QUESTIONS
AND ANSWERS
What is a carbonic anhydrase? - answer- Converts CO2, into bicarbonate to facilitate
its transport to the lungs.
Reacts a molecule of CO2 with a water molecule.
Activity decreases the pH of red blood cells.
Is present within red blood cells.
The molecular basis of sickle cell anemia is? - answer- A single animo acid change
in hemoglobin
Which of the following combinations would cause the greatest decrease in
hemoglobin's affinity for oxygen? - answer- Decreased pH, increase in 2,3
biphosphoglycerate
Which of the following lists the proteins from highest to lowest oxygen affinity? -
answer- Myoglobin, fetal hemoglobin, adult hemoglobin
2,3 Bis phosphoglycerate serves as a _ of hemoglobin? - answer- Hetertropic
allosteric inhibitor
The p50 of hemoglobin is approximately equal to what? - answer- Partial pressure of
oxygen in the periphery
The Bohr effect describes what? - answer- The pH dependence of hemoglobin
affinity for oxygen
The interface of the four subunits of hemoglobin provides the binding site for? -
answer- 2,3 bis phosphoglycerate
What does the sigmoidal shape of hemoglobin's binding curve? - answer- Indicates
coopertivity
Makes hemoglobin highly responsive to changes in the partial pressure of oxygen
Enables hemoglobin to fully saturate with oxygen in the lungs and release the
oxygen to the periphery
Is a consequence of hemoglobin being an allosteric protein
Which protein does not utilize heme groups to enable oxygen binding? - answer-
Hemocyanin
Oxygen serves as a _ of hemoglobin? - answer- Homotropic allosteric activator
For oxygen saturation plots, the x axis corresponds to ? - answer- The partial
pressure of oxygen
AND ANSWERS
What is a carbonic anhydrase? - answer- Converts CO2, into bicarbonate to facilitate
its transport to the lungs.
Reacts a molecule of CO2 with a water molecule.
Activity decreases the pH of red blood cells.
Is present within red blood cells.
The molecular basis of sickle cell anemia is? - answer- A single animo acid change
in hemoglobin
Which of the following combinations would cause the greatest decrease in
hemoglobin's affinity for oxygen? - answer- Decreased pH, increase in 2,3
biphosphoglycerate
Which of the following lists the proteins from highest to lowest oxygen affinity? -
answer- Myoglobin, fetal hemoglobin, adult hemoglobin
2,3 Bis phosphoglycerate serves as a _ of hemoglobin? - answer- Hetertropic
allosteric inhibitor
The p50 of hemoglobin is approximately equal to what? - answer- Partial pressure of
oxygen in the periphery
The Bohr effect describes what? - answer- The pH dependence of hemoglobin
affinity for oxygen
The interface of the four subunits of hemoglobin provides the binding site for? -
answer- 2,3 bis phosphoglycerate
What does the sigmoidal shape of hemoglobin's binding curve? - answer- Indicates
coopertivity
Makes hemoglobin highly responsive to changes in the partial pressure of oxygen
Enables hemoglobin to fully saturate with oxygen in the lungs and release the
oxygen to the periphery
Is a consequence of hemoglobin being an allosteric protein
Which protein does not utilize heme groups to enable oxygen binding? - answer-
Hemocyanin
Oxygen serves as a _ of hemoglobin? - answer- Homotropic allosteric activator
For oxygen saturation plots, the x axis corresponds to ? - answer- The partial
pressure of oxygen
