APHON CHEMO AGENTS & CLASSIFICATIONS EXAM QUESTIONS AND ANSWERS 100% CORRECT!!

alkylating agents - ANSWER non-specific. although most active in resting phase. cause dna strand breaks antimetabolites - ANSWER interfere w/ cell metabolism by inhibiting enzyme production or producing nonfunctional end product. interrupts protein synthesis, rna, or dna anthracyclines - ANSWER prevent rejoining of cleaved dna strands by inhibiting topoisomerase ii (dna untangling enzyme). also forms hydroxyl radicals which attack dna/cell membrane lipids (cardiotoxic) give cardioprotective agents alongside abx are subset but breakdown is usually stable plant derivatives - ANSWER vinca alkaloids - vcr, vinblastine, vinorelbine, vindesine tubulin interactive agets: interfere w/ microtubule formation/function leading to arrest in mitosis. cell cycle specific taxanes - ANSWER plant derivitive that inhibits microtubular disassembly necessary to finish mitosis epipodophyllotoxins - ANSWER etoposide, teniposide inhibit topoisomerase ii and produce dna-strand breaks cell cycle specific camptothecin - ANSWER topotecan, irinotecan inhibit topoisomerase i causing dna-strand breaks & cell death asparaginase - ANSWER misc agent. L/PEG: cell-cycle non-specific enzyme, coated w/ polyethylene glycol & decreases immunogenicity of enzyme. hydroxurea - ANSWER misc agent. inhibits dna synthesis causing cell death in s phase procarbazine - ANSWER misc agent active in g2 phase by breaking single strand dna shortly after dna synthesis corticosteroids - ANSWER modifies transcription process in dna formation dexamethasone, prednisone antiangiogenic agents - ANSWER pvt growth of new blood vessels tumors depend on for growth and metastases by: