MMSC 491 Exam 3 Questions Well Answered Latest Update

MMSC 491 Exam 3 Questions Well Answered Latest Update What is the most appropriate gene therapy for treating cancer? a. Repair of mutant gene b. Modifying disease cells c. Killing disease cells d. Gene augmentation - Answers Killing disease cells How do cancer cells avoid chromosome destabilization due to their rapidly shortening telomeres? - Answers They express telomerase In cancer cells, hypomethylation of DNA results in... - Answers None of the above Which of the following databases contains descriptions of genomic, transcriptomic, and epigenetic changes in different types of tumors? - Answers ICGC Which of the following discoveries in cancer research is a direct result of the advent of next-generation sequencing? - Answers Extraordinary mutational diversity in tumors Which of the following is not a method of oncogene activation? - Answers RAS/RAF pathway activation Which of the following is true about miRNA in cancer cells? - Answers miRNAs have regulatory rules in apoptosis, cell-cycle control and DNA damage responses Which of the following can result from telomere instability in cancer cells? - Answers The cell does not recognize the DNA as a chromosome and fuses it to another chromosome Which of the following regarding genome wide gene expression screens is false? - Answers The hybridization probes bind to proteins within the cell Which of the following is defined as large numbers of chromosomal rearrangements are generated in what appear to be single catastrophic events? - Answers Chromothripsis During a tumor removal surgery, the tumor is found to be a small mass of cells that has not affected any neighboring tissues. Several months later the patient is re-evaluated and is not showing any signs of recurrence. What kind of tumor did the patient most have? - Answers Benign tumor Which of the following is NOT a characteristic of cancer cells? - Answers Increased genome stability Which of the following correctly matches the treatment type with the definition? - Answers Stratified medicine: dividing tumors into major subtypes that will have similar and predictable responses to drugs Programmed cell death is known as - Answers Apoptosis What kind of tumor can occur in the single-layer or bilayer of epithelial tissue? - Answers Adenoma What type of tumor is associated with the oncogene MYC (8q24)? - Answers Burkitt's Lymphoma Which cancer has the largest variation of somatic nonsynonymous mutations per tissue? - Answers Lung (NSCLC) Which biological capability involves inhibitors of VEGF signaling? - Answers Inducing angiogenesis Which of the following is true about Landscaper genes? - Answers Control stromal environment Which type of genome sequencing has the ability to evaluate entire genomes examining cancer genes simultaneously? - Answers Massively parallel DNA sequencing (Next-generation DNA sequencing) Which long noncoding RNA has been shown to upregulated in GASTRIC cancer? - Answers H19 Comparative hybridization is... - Answers Comparing gene expression of cancer cells Which cancer genes are dominantly acting? - Answers Oncogenes Which of the following statements is FALSE with regard to oncogenes and tumor suppressor genes? - Answers Both alleles of a classical oncogene are inactivated in order to make a significant contribution to cancer development Which of the following is NOT an example of a cancer genomic database? - Answers PubMed Which genes products regulate cell division by regulating the cell cycle and inducing cell cycle arrest as required by working in upstream growth signaling pathways or they promote apoptosis? - Answers Gatekeeper genes Which of the following tumors are benign? - Answers Adenoma Defective mismatch repair is most commonly associated with which type of cancer? - Answers Colorectal cancer What is defined as a process that cells are unwanted, heavily damaged, or actively dangerous are normally induced to kill themselves? - Answers Apoptosis Which kinds of cancer are associated with the HIGHEST mutation number? - Answers Defective DNA repair (colorectal (MSI))