TESTBANK
h
, Chapter1:PrinciplesofPharmacology h h h h
Multiple Choice h
1. refer(s) to specific molecular changes that occur when a drug binds to a
h h h h h h h h h h h h
particular target site or receptor, while
h h aretheresulting widespread alterations
h h h h h h h h
in function.
h h
a. Drug action; therapeutic effects
h h h
b. Side effects; drug effects
h h h
c. Therapeutic effects; side effects h h h
d. Drug action; drug effects
h h h
Answer: d h
Textbook Reference: Pharmacology: The Science of Drug Action
h h h h h h h
2. After drug administration has occurred, the amount of drug in the blood that is free to bind
h h h h h h h h h h h h h h h h
at specific target sites is referred to as
h h h h h h h h
a. the therapeutic dose.
h h
b. first-pass effects. h
c. bioavailability.
d. ED50.
Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
3. The specific molecular changes that occur when a drug binds to a particular target site or
h h h h h h h h h h h h h h h
receptor are referred to as
h h h h h
a. drugeffects. h
b. drug action. h
c. side effects.
h
d. placebo effects. h
Answer: b h
TextbookReference: Pharmacology: TheScience of Drug Action
h h h h h h h
4. Which of the following is not a possible explanation for placebo effects?
h h h h h h h h h h h
a. Pavlovian conditioning h
b. Genetic variation h
c. Drug competition h
d. Expectation of outcome h h
Answer: c h
TextbookReference: Pharmacology: The Science of Drug Action
h h h h h h h
Page 1 of 247
h h h
,5. The administration of oxytocin has been proposed as a treatment for autism. h h h h h h h h h h
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c h
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
6. Which factor does not affect the pharmacokinetics of a drug?
h h h h h h h h h
a. Route of administration
h h
b. Lipid solubility
h
c. Depot binding h
d. Drugaction h
Answer: d h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
7. First-pass metabolism occurs when drugs are taken
h h h h h h
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a h
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
8. The area postrema is one area in the brain where the
h h is not complete. h h h h h h h h h h
a. cerebrospinal fluid h
b. blood–brain barrier h
c. choroid plexus h
d. phospholipid membrane h
Answer: b h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
9. First-pass metabolism occurs with orally administered drugs because
h h h h h h h
a. their absorption is slowed by food.
h h h h h
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
h h h h h h h h h h h h h h h
general circulation.
h h
c. drugs must first survive the acidic environment of the stomach.
h h h h h h h h h
d. salivaryenzymes in the mouth begin the process of metabolism.
h h h h h h h h h
Answer: b h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
10. Toxic substances in the blood trigger a vomiting response by activating the
h h h h h h h h h h h
a. blood–brain barrier. h
b. choroid plexus. h
c. area postrema.
h
d. median eminence. h
Page 2 of 247
h h h
, Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
11. Drugs administered _ have the most rapid onset of action.
h h h h h h h h
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
12. Ionization of a drug depends on the of the solution and the
h h h h h h h h h h ofthe
h
drug.
h
a. pH; pKa
h
b. pKa; pH h
c. concentration; lipid solubility h h
d. pH; concentration
h
Answer: a h
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
13. The absorption of a drug depends on all of the following except
h h h h h h h h h h h
a. lipid solubility.
h
b. ionization.
c. body temperature. h
d. the concentration of the drug.
h h h h
Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
14. Drugs that are should be avoided by women of childbearing age.
h h h h h h h h h
a. teratogenic
b. able to cross the placental barrier
h h h h h
c. psychoactive
d. highly lipid-soluble h
Answer: a h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
15. Agents that induce developmental abnormalities in a fetus are known as
h h h h h h h h h h
a. psychoactivedrugs. h
b. illicit drugs. h
c. teratogens.
d. placental drugs. h
Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
16. Depot binding is said to occur when drugsh h h h h h h
a. bind to their target sites.
h h h h
Page 3 of 247
h h h
h
, Chapter1:PrinciplesofPharmacology h h h h
Multiple Choice h
1. refer(s) to specific molecular changes that occur when a drug binds to a
h h h h h h h h h h h h
particular target site or receptor, while
h h aretheresulting widespread alterations
h h h h h h h h
in function.
h h
a. Drug action; therapeutic effects
h h h
b. Side effects; drug effects
h h h
c. Therapeutic effects; side effects h h h
d. Drug action; drug effects
h h h
Answer: d h
Textbook Reference: Pharmacology: The Science of Drug Action
h h h h h h h
2. After drug administration has occurred, the amount of drug in the blood that is free to bind
h h h h h h h h h h h h h h h h
at specific target sites is referred to as
h h h h h h h h
a. the therapeutic dose.
h h
b. first-pass effects. h
c. bioavailability.
d. ED50.
Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
3. The specific molecular changes that occur when a drug binds to a particular target site or
h h h h h h h h h h h h h h h
receptor are referred to as
h h h h h
a. drugeffects. h
b. drug action. h
c. side effects.
h
d. placebo effects. h
Answer: b h
TextbookReference: Pharmacology: TheScience of Drug Action
h h h h h h h
4. Which of the following is not a possible explanation for placebo effects?
h h h h h h h h h h h
a. Pavlovian conditioning h
b. Genetic variation h
c. Drug competition h
d. Expectation of outcome h h
Answer: c h
TextbookReference: Pharmacology: The Science of Drug Action
h h h h h h h
Page 1 of 247
h h h
,5. The administration of oxytocin has been proposed as a treatment for autism. h h h h h h h h h h
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c h
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
6. Which factor does not affect the pharmacokinetics of a drug?
h h h h h h h h h
a. Route of administration
h h
b. Lipid solubility
h
c. Depot binding h
d. Drugaction h
Answer: d h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
7. First-pass metabolism occurs when drugs are taken
h h h h h h
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a h
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
8. The area postrema is one area in the brain where the
h h is not complete. h h h h h h h h h h
a. cerebrospinal fluid h
b. blood–brain barrier h
c. choroid plexus h
d. phospholipid membrane h
Answer: b h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
9. First-pass metabolism occurs with orally administered drugs because
h h h h h h h
a. their absorption is slowed by food.
h h h h h
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
h h h h h h h h h h h h h h h
general circulation.
h h
c. drugs must first survive the acidic environment of the stomach.
h h h h h h h h h
d. salivaryenzymes in the mouth begin the process of metabolism.
h h h h h h h h h
Answer: b h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
10. Toxic substances in the blood trigger a vomiting response by activating the
h h h h h h h h h h h
a. blood–brain barrier. h
b. choroid plexus. h
c. area postrema.
h
d. median eminence. h
Page 2 of 247
h h h
, Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
11. Drugs administered _ have the most rapid onset of action.
h h h h h h h h
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
12. Ionization of a drug depends on the of the solution and the
h h h h h h h h h h ofthe
h
drug.
h
a. pH; pKa
h
b. pKa; pH h
c. concentration; lipid solubility h h
d. pH; concentration
h
Answer: a h
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
13. The absorption of a drug depends on all of the following except
h h h h h h h h h h h
a. lipid solubility.
h
b. ionization.
c. body temperature. h
d. the concentration of the drug.
h h h h
Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
14. Drugs that are should be avoided by women of childbearing age.
h h h h h h h h h
a. teratogenic
b. able to cross the placental barrier
h h h h h
c. psychoactive
d. highly lipid-soluble h
Answer: a h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
15. Agents that induce developmental abnormalities in a fetus are known as
h h h h h h h h h h
a. psychoactivedrugs. h
b. illicit drugs. h
c. teratogens.
d. placental drugs. h
Answer: c h
TextbookReference: Pharmacokinetic Factors Determining Drug Action
h h h h h h
16. Depot binding is said to occur when drugsh h h h h h h
a. bind to their target sites.
h h h h
Page 3 of 247
h h h
