Advanced Pharmacology Final UPDATED ACTUAL Questions and
CORRECT Answers
1. A 64-year-old man presents with mild to moderate C. Naproxen and omepra-
musculoskeletal zole
back pain. He states that he has tried acetaminophen
without relief. His medical history includes diabetes,
hypertension, hyperlipidemia, gastric ulcer (resolved),
and coronary artery disease. Which is the
most appropriate NSAID regimen to treat this pa-
tient's pain?
A. Celacoxib
B. Indomethacin and omeprazole
C. Naproxen and omeprazole
D. Naproxen
2. Which statement is correct regarding the difference C. Acetaminophen has less
between acetaminophen and naproxen? risk for CV events com-
pared with naproxen.
A. Acetaminophen has more anti-inflammatory ef-
fects compared with naproxen.
B. Acetaminophen has more Gl side effects but less
effects on bleeding compared with naproxen.
C. Acetaminophen has less risk for CV events com-
pared with naproxen.
D. Acetaminophen has fewer antipyretic effects than
naproxen.
3. Which statement correctly describes the proposed B. Aspirin preferentially in-
mechanism of cardioprotection from low-dose as- hibits COX-1 to lead to
pirin? a relative reduction in
A. Aspirin preferentially inhibits COX-2 to lead to a thromboxane ~ levels.
relative reduction in thromboxane ~ levels.
, B. Aspirin preferentially inhibits COX-1 to lead to a
relative reduction in thromboxane ~ levels.
C. Aspirin preferentially inhibits COX-2 to lead to a
relative reduction in prostacyclin levels.
D. Aspirin preferentially inhibits COX-1 to lead a rela-
tive reduction in prostacyclin levels.
4. Which statement correctly describes the pathophysi- D. Decrease secretion of
ologic actions of prostaglandins at a target tissue? gastric acid in the stomach
A. Promote vasoconstriction in the kidneys.
B. Promote sodium and water retention in the kid-
neys.
C. Decrease secretion of mucus at the lining of the
stomach.
D. Decrease secretion of gastric acid in the stomach
5. Which prostaglandin agent can be used to maintain D. Alprostadil
the patency of the ductus arteriosus in neonates with
congenital heart problems while awaiting surgery?
A. Misoprostol
B. Epoprostenol
C. Bimatoprost
D. Alprostadil
6. A 34-year-old woman with RA is planning for pregnan- D. Methotrexate and
cy. Which RA agents are absolutely contraindicated leflunomide
in pregnancy?
A. Abatacept and rituximab
B. Adalimumab and certolizumab
C. lnfliximab and etanercept
D. Methotrexate and leflunomide
,7. Which agent for RA competes with CD28 to prevent B. Abatacept
full T-cell activation?
A. Sarilumab
B. Abatacept
C. Golimumab
D. Adalimumab
8. Which statement correctly represents the mechanism B. Janus kinase inhibitor
of action of tofacitinib in the treatment of RA?
A. TNF-a inhibitor
B. Janus kinase inhibitor
C. IL-6 receptor blocker
D. Dihydrofolate reductase inhibitor
9. A 54-year-old man with gout is found to have an issue C. Probencid
with renal excretion of uric acid. Which drug is an oral
agent that would target the cause of his acute gout
attacks?
A. Allopurinol
B. Febuxostat
C. Probenecid
D. Pegloticase
10. A 64-year-old man presents with signs and symptoms C. Probenecid
of an acute gouty flare. Which strategy is the least like-
ly to acutely improve his gout symptoms and pain?
A. Naproxen
B. Colchicine
, C. Probenecid
D. Prednisone
11. A 43-year-old heavy machine operator complains of D. Fexofenadine
seasonal allergies. Which medication is most appro-
priate for the management of his allergy symptoms?
A. Diphenhydramine
B. Doxylamine
C. Hydroxyzine
D. Fexofenadine
12. Which statement concerning H, antihistamines is cor- A. Second-generation H1
rect? antihistamines are rela-
tively free of adverse ef-
A. Second-generation H1 antihistamines are relatively fects.
free of adverse effects.
B. Because of the established long-term safety of
first-generation H1 antihistamines, they are the first
choice for allergic rhinitis.
c. The motor coordination involved in driving an auto-
mobile is not affected by the use of first-generation H,
antihistamines.
D. H1 antihistamines can be used in the treatment of
acute anaphylaxis.
13. Which histamine receptor antagonist is known to en- A. Hydroxyzine
ter the central nervous system readily and cause se-
dation?
A. Hydroxyzine
CORRECT Answers
1. A 64-year-old man presents with mild to moderate C. Naproxen and omepra-
musculoskeletal zole
back pain. He states that he has tried acetaminophen
without relief. His medical history includes diabetes,
hypertension, hyperlipidemia, gastric ulcer (resolved),
and coronary artery disease. Which is the
most appropriate NSAID regimen to treat this pa-
tient's pain?
A. Celacoxib
B. Indomethacin and omeprazole
C. Naproxen and omeprazole
D. Naproxen
2. Which statement is correct regarding the difference C. Acetaminophen has less
between acetaminophen and naproxen? risk for CV events com-
pared with naproxen.
A. Acetaminophen has more anti-inflammatory ef-
fects compared with naproxen.
B. Acetaminophen has more Gl side effects but less
effects on bleeding compared with naproxen.
C. Acetaminophen has less risk for CV events com-
pared with naproxen.
D. Acetaminophen has fewer antipyretic effects than
naproxen.
3. Which statement correctly describes the proposed B. Aspirin preferentially in-
mechanism of cardioprotection from low-dose as- hibits COX-1 to lead to
pirin? a relative reduction in
A. Aspirin preferentially inhibits COX-2 to lead to a thromboxane ~ levels.
relative reduction in thromboxane ~ levels.
, B. Aspirin preferentially inhibits COX-1 to lead to a
relative reduction in thromboxane ~ levels.
C. Aspirin preferentially inhibits COX-2 to lead to a
relative reduction in prostacyclin levels.
D. Aspirin preferentially inhibits COX-1 to lead a rela-
tive reduction in prostacyclin levels.
4. Which statement correctly describes the pathophysi- D. Decrease secretion of
ologic actions of prostaglandins at a target tissue? gastric acid in the stomach
A. Promote vasoconstriction in the kidneys.
B. Promote sodium and water retention in the kid-
neys.
C. Decrease secretion of mucus at the lining of the
stomach.
D. Decrease secretion of gastric acid in the stomach
5. Which prostaglandin agent can be used to maintain D. Alprostadil
the patency of the ductus arteriosus in neonates with
congenital heart problems while awaiting surgery?
A. Misoprostol
B. Epoprostenol
C. Bimatoprost
D. Alprostadil
6. A 34-year-old woman with RA is planning for pregnan- D. Methotrexate and
cy. Which RA agents are absolutely contraindicated leflunomide
in pregnancy?
A. Abatacept and rituximab
B. Adalimumab and certolizumab
C. lnfliximab and etanercept
D. Methotrexate and leflunomide
,7. Which agent for RA competes with CD28 to prevent B. Abatacept
full T-cell activation?
A. Sarilumab
B. Abatacept
C. Golimumab
D. Adalimumab
8. Which statement correctly represents the mechanism B. Janus kinase inhibitor
of action of tofacitinib in the treatment of RA?
A. TNF-a inhibitor
B. Janus kinase inhibitor
C. IL-6 receptor blocker
D. Dihydrofolate reductase inhibitor
9. A 54-year-old man with gout is found to have an issue C. Probencid
with renal excretion of uric acid. Which drug is an oral
agent that would target the cause of his acute gout
attacks?
A. Allopurinol
B. Febuxostat
C. Probenecid
D. Pegloticase
10. A 64-year-old man presents with signs and symptoms C. Probenecid
of an acute gouty flare. Which strategy is the least like-
ly to acutely improve his gout symptoms and pain?
A. Naproxen
B. Colchicine
, C. Probenecid
D. Prednisone
11. A 43-year-old heavy machine operator complains of D. Fexofenadine
seasonal allergies. Which medication is most appro-
priate for the management of his allergy symptoms?
A. Diphenhydramine
B. Doxylamine
C. Hydroxyzine
D. Fexofenadine
12. Which statement concerning H, antihistamines is cor- A. Second-generation H1
rect? antihistamines are rela-
tively free of adverse ef-
A. Second-generation H1 antihistamines are relatively fects.
free of adverse effects.
B. Because of the established long-term safety of
first-generation H1 antihistamines, they are the first
choice for allergic rhinitis.
c. The motor coordination involved in driving an auto-
mobile is not affected by the use of first-generation H,
antihistamines.
D. H1 antihistamines can be used in the treatment of
acute anaphylaxis.
13. Which histamine receptor antagonist is known to en- A. Hydroxyzine
ter the central nervous system readily and cause se-
dation?
A. Hydroxyzine
