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Introduction to Clinical Pharmacology 11th Edition

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Test Bank for Principles of Anatomy and Physiology () Questions and fully Researched Rationales 100% Verified A+ Guarantee. Motor system - ANSWERSall parts of the brain and spinal cord that are devoted to the OUTPUT of the nervous system. nervous system has what functions - ANSWERSsensory, processing and motor Outputs of the nervous system - ANSWERSmotor funcitons 2 types motor output - ANSWERSvisceral motor, somatic motor visceral motor - ANSWERSsmooth muscle, cardiac, muscle and glands somatic motor - ANSWERSskeletal muscle, voluntary myscle brodmann numbers responsible for movement are: - ANSWERSin frontal lobe, area 4, 6, 8, 44 &45 area 4 - ANSWERSprecentral gyrus: primary motor cortex, sending axons to alpha motor neurons of spinal cord (executing movement) area 6 supplementary motor area - ANSWERSplanning or imagining movement area 8 - ANSWERSfrontal eye fields, eye movements area 44 & 45 - ANSWERSbrocas area. in most people brocas area on the left side is reponsible for the production of speech ( movement of throuat and tongue) primary motor cortex - ANSWERSregion where signal controlling movement originates. anatomically: precentral gyrus, all consciousness is in cortex, so only sonsious planned movement starts here. motor homunculous - ANSWERSface areas found more lateral part of precentral grus, as move up to midline encounter in order : hand arm shoulder, trunk, hip, leg, toes The lateral surface of brain is suppplied by - ANSWERSdifferent set of arteries and arterial branches than then the medial surface of the brain. stroke in right lateral precentral gyrus stroke in irght medial precentral gyrus - ANSWERSparalysis left side of face paralysis of the left leg pryamidal system- - ANSWERSinfo about conscious willed movement is planned in 2 areas of brain cortex. cells in this region send axons down through a important CNS tract called this... pryamidal system: definition - ANSWERSsingle group of axons the inexplicably chages namesfour or five times. starting as internal capsule, change names twice and then emerges on ventral surface of medulla as (medullary) yramids and then decussates at the decussation of the pyramids ( at the foramen magnum) then becomes the lateral corticospinal tract in spinal cord. these are upper motor neurons corticospinal tract - ANSWERSpathway from motor cortex to spinal cord motor pathways - ANSWERScell bodies in precentral gyrus, send zxons down spinal cord, pathway changes names several times but theyre the same axons name change of motor pathway - ANSWERSinternal capsule, near thalmus phyramids in medulla decussation of pyramids (pyramidal decussation) lateral corticospinal tract in spinal cord decussate - ANSWERScross in the form of "X" Decussation of the pyramids - ANSWERSwhere the info corsses form left side of brain to the right side of body and vise versa lateral corticospinal tract - ANSWERSmotor info from the motor region of cerbrum (motor cortex) travel here. when axons reagh the right level they enter the anterior horn and make synapses onto motor neurons there. make synaptic contact onto the alpha motor neuron that will innervate the correct muscle the alpha motor neuron is a lower motor neuron. motor neuron - ANSWERSregulate movement...each effector of motor system is controlled by a nerve cell. last point of contact between the nerovus systema dn effector organ. receive input from brain through spinal cord, and a reflex pathway within the spinal cord. generate electrical impulse (action potential) which travels along axon to axon terminal excitation-contraction coupling - ANSWERSanatomically the strucute where nerve contacts muscle is called neuroomuscular junction or motor end plate. special name for the synapse between muscle and nerve. somatic motor systems pathway - ANSWERSeffector organ receives baton is skeletal muscle. baton is the neurotransmitter acetylcholine and it acts on nicotinic acetylcholine receptors (nAChRs) in the mosucle postsynaptic membrane the receptors are excitory because they allow na and K ions to pass when activated. the process triggered by nAChRs is called exciataiton contraction coupling. action potential at neuromuscular junction - ANSWERSimpulse trigger realease of acetylcholine, acetylcholine diffuses across the space between nerve and muscle cell triggering muscle cell action potential. this evenuall caus Ca release from stores in muscle. action potential travels along muscle surface. ACh removed by enzyme acetylcholinesterase (AChE) for visceral systems what neurotransmitters released - ANSWERSacetylcholine if parasympatheric, or norepinephrine if sympatheric. acetylcholine neurotransmitter.. receptor? - ANSWERSmuscarinic acetylcholine receptors (either inhibitory or excitatory) norepinephrine neurotransmitter.. receptor? - ANSWERSalpha or beta adrenergic terminology for somatic movement systems - ANSWERSlower motor neuron, upper motor neuron lower motor neuron - ANSWERSused to refer to the neuron that makes the final contact between nerovus sysem and effector organ. directly innervate skeletal muscle. ex. alpha motor neuron alpha motor neuron - ANSWERScell bodies in ventral horn of spinal cord and axon that travels as part of anerve to end in a neuromuscular junciton on skeletal muscle. upper motor neuron - ANSWERSall other neurons in brain and spinal cord that influence movement but don not make direct contact with a skeletal muscle fiber. ex. neurons of precentral gyrus (primary motor cortex), neurons in basal ganglia (basal nuclei) and neurons of the cerebellum sensory systems - ANSWERSparts of the nervous system that receive information from external or internal enviornment. relevan stimulus - ANSWERSeach receptor has relevant stimulus which is the kind of environmental energy it is capable of transducing. energy form the environment is generally not in a form that the nerovus system can use directly. ex photons (vison) chemicals present in environment around receptor, pressure waves of sound (hearing) or temperature. ... so photoreceptors dont care what temp it is. transduciton - ANSWERSprocess through which environmental energy is transformed into nervous systemenergy is called transduction. first step in any sensory system thalmus - ANSWERSdecides which stimuli reach conscionusness so all sensory systems are routed through thalmus before reach cortex... except olfaction steps of sensory system, - ANSWERSstimuli, transduciton, infor relay to cortex for consciousness, thalmus, there is a region of cortex responsible for perception of each kind of sensation. if it does not reach cortex it is not perceived. ex. we are aware of something touching skin so skin pressure, but not blood pressure. receptors - ANSWERSexteroceptors, interoceptors, proprioceptors exteroceptros - ANSWERSreceive stimuli form external environment. ex. light waves that are reflected off objects in environsment. pressure waves of air hit eardrum to create perception of sound. all stimuli from outside body 5 senses (sight, hearing, touch, taste, smell)could also add force of gravity...as a steady pull or in movement ( vestibular sense) interoceptros - ANSWERSreceve energy from internal environment. es. oxygen levels, glucose levels, pH in blood. do not reach conscious perception proprioceptor - ANSWERSintegrate info about state of stretch of skin muscles and tendoons with info about gravity to produce a perception of where our joints are in space. ex. if close eyes and someone lifts leg you perceive that your leg is extended even though you dont see it. its the position of joints, muscles and tendons. 6 stimuli for sensory receptors - ANSWERSmechanoreceptors, thermoreceptors, nociceptors, photoreceptros, chemoreceptros, osmoreceptors mechanoreceptors, - ANSWERSdetect movement, such as pressure of clothes on skin or finger touching you, muscle stretched, pressure waves of air (sound). somatosensory, proprioception, auditory, vestibular(ba

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Test Bank on Introduction to Clinical
Pharmacology 11th Edition 100%
Verified Answers



What is the definition of clinical pharmacology? - ANSWERSA discipline spanning the
spectrum of drug delivery, drug development, drug utilization, and drug regulation

What are the words for the following blanks?

Clinical Pharmacology is aimed at advancing therapeutics in humans with mechanistic
understanding of drug actions _____ and drug disposition _____ -
ANSWERSpharmacodynamics and pharmacokinetics

What is the definition of translational sciences? - ANSWERSKnowledge acquired in
animal or in silico models of disease, ex-vivo studies in human tissues, or in vivo studies
in healthy or diseased humans is translated into effective treatment for patients

What is the starting dose of Phase I trial? - ANSWERSone tenth of LD50 for cancer or
phytotoxins

What are the professional goals of clinical pharmacologists? - ANSWERSDiscover,
develop and evaluate new medicines, regulate their use

Optimize the use of existing medicines, find new indications

Define the basis for variability in therapeutic and toxic responses to medicines

What is the measurement to see whether some toxicities can be managed and may be
acceptable? - ANSWERSrisk/benefit ratio

What is the characteristic of Risk/Benefit ratio? - ANSWERSIt is contextual, which tells
you it is depending on the drug and disease that we intend to treat

For example, it is not the same to consider potentially serious toxicity for a drug
intended to treat HYT, which is a medical condition that needs lifelong therapy,
compared to treatment of cancer, a disease that is potentially lethal over the short term,
and that requires very intense treatment with combination of drugs that have very
significant toxicity

, _____ is a condition or brings up situations, if you will, where an underlying genetic
variant may predispose individuals to severe toxicity to drugs - ANSWERSGenetics

What is the name of genetic variant and the name of antiviral drug?

Individuals that carry _____ variant are at very high risk of _____ hypersensitivity. This
drug is used in the treatment of HIV infections and AIDS, and prior to instituting
treatment with the drug, every pt is first tested for this variant, _____, and alternatives
must be found if the patient have the variant - ANSWERSHLA-B*5701 and abacavir

What is the name drug that causes the-drug-induced liver disease (DILI) and the name
of variant associated with this DILI? - ANSWERSFlucoxacillin and HLA-B *5701

What is the name of genetic variant and the name of drug?

_____ may predispose to severe _____-induced, a serious cutaneous ADR that actually
can be fatal - ANSWERSHLA-B*1502 and Carbamazepine

What is the name of drug-induced disease associated with HLA-B*1502? -
ANSWERSStevens-Johnson syndrome

What is the name of disease exemplified as unacceptable drug toxicity that induces an
abnormal, life-threatening episode/ADR of the polymorphic ventricular tachycardia that
you might be able to see in ECG record - ANSWERSTorsades de Pointes

What is the name of drug that was historically the first non-sedating antihistamine
under the brand name of Seldane, but subsequently withdrawn from the market due to
the risk of drug-induced arrhythmias? - ANSWERSTerfenadine

What are the words in the blanks?

_____ is carboxylic metabolite of _____ which is a non-sedating antihistamine under the
brandname of Allegra but does not have the risk of a drug-induced arrhythmia. Recently
it is also called _____ - ANSWERSTerfenadine Carboxylate, Terfenadine, and
Fexofenadine

What would we learn from the examples of Terfenadine and its carboxylic metabolite? -
ANSWERSIt brings us to consider and remember the importance of studying drug
metabolism and assessing whether metabolites are also pharmacologically active or are
otherwise inactive ones, whether transformation has taken place

What is the name of drug that was not allowed to enter the US market after approved in
the US due to some severe toxicity to unborn children expressed by prenatal drug
exposure: an epidemic worldwide of phocomelia, children born with severe defects in
terms of their limbs - ANSWERSThalidomide

, What is the starting step in development and evaluation of new drugs? -
ANSWERSDrug discovery

What is the step that animal testing of candidate drugs and evaluation to demonstrate
safety in humans and whether or not the drug is effective in a given clinical condition
while conducted in development and evaluation of new drugs? - ANSWERSPre-clinical
and clinical evaluation

What is the step in which, once the drug enters the market, experts continue to
evaluate for the possibility of rare ADRs that were not discovered in the pre-approval
stage, and also performing studies in special populations like geriatric and pediatric
populations? - ANSWERSPost-marketing studies

What are done in Pre-Clinical Development? - ANSWERSChemical Synthesis and
Formulation Development

Animal Models for Efficacy

Assay Development

Animal PK and PD

Animal Toxicology

What is the case for which Animal Toxicology continues in the long term? -
ANSWERSIf the drug is intended for chronic use

What is the next step once a package of information is developed that indicates the
candidate drug may, in fact, be promising? - ANSWERSAn investigational new drug
application, the IND, is filed with the FDA or other regulatory agencies and process of
evaluating the drug in humans starts by Clinical Development: Phase I, Phase II, and
Phase III

What is studied in Phase I? - ANSWERSTypically, it is considered first dose in human
studies and dose escalations are evaluated to assess tolerance

What is studied in Phase II? - ANSWERSThe proof of concept studies is done by
treating patients with the condition that may benefit, potentially from the drugs

What is studied in Phase III? - ANSWERSThe large randomized clinical trials are
conducted by comparing the new drug to a placebo or to a previously established
therapy

What would we see after Phase III is finished up? - ANSWERSThe finish leads to the
submission of a new drug application, or NDA, where the sponsor asks the regulatory

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