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, Table of contents b b
Chapter 1 - Cellular Biology ____________________________________________________________ 3
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Chapter 2 - Altered Cellular and Tissue Biology Environmental Agents
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bEnvironment Fluids and Electrolytes Acids and b b b b b
Bases ______________________________________________________________________________ 28
Chapter 4 - Genes and Genetic Diseases ___________________________________________________ 41
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Chapter 5 - Genes Environment-Lifestyle and Common Diseases ________________________________ 51
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Chapter 6 - Epigenetics and Disease _______________________________________________________ 59
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Chapter 7 - Innate Immunity Inflammation ___________________________________________________ 64
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Chapter 8 - Adaptive Immunity ____________________________________________________________ 78
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Chapter 9 - Alterations in Immunity and Inflammation ________________________________________ 89
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Chapter 10 - Infection _________________________________________________________________ 102
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Chapter 11 - Stress and Disease ________________________________________________________ 110
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Chapter 12 - Cancer Biology ___________________________________________________________ 117
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Chapter 13 - Cancer Epidemiology ______________________________________________________ 129
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Chapter 14 - Cancer in Children _________________________________________________________ 135
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Chapter 15 - Structure and Function of the Neurologic System _________________________________ 140
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Chapter 16 - Pain Temperature Regulation Sleep and Sensory Function 151 Chapter 17 - Alterations in
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bCognitive Systems Cerebral Hemodynamics and
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Motor Function ______________________________________________________________________ 165
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Chapter 18 - Disorders of the Central and Peripheral Nervous Systems and
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the Neuromuscular Junction ___________________________________________________________ 179
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Chapter 19 - Neurobiology of Schizophrenia Mood Disorders and Anxiety Disorders
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Chapter 20 - Alterations of Neurologic Function in Children ___________________________________ 195
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Chapter 21 - Mechanisms of Hormonal Regulation
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b b b b 202 Chapter 22 - Alterations of Hormonal Regulation __________________________________ 211
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Chapter 23 - Obesity and Disorders of Nutrition NEW ________________________________________ 223
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Chapter 24 - Structure and Function of the Reproductive Systems ______________________________ 228
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Chapter 25 - Alterations of the Female Reproductive System __________________________________ 237
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Chapter 26 - Alterations of the Male Reproductive System_____________________________________ 246
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,Chapter 27 - Sexually Transmitted Infections ____________________________ 252
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Chapter 28 - Structure and Function of the Hematologic System ______________ 260
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Chapter 29 - Alterations of Erythrocyte Platelet and Hemostatic Function _______ 270
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Chapter 30 - Alterations of Leukocyte and Lymphoid Function _______________ 280
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Chapter 31 - Alterations of Hematologic Function in Children ________________ 287
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Chapter 32 - Structure and Function of the Cardiovascular and Lymphatic Systems
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______________________________________________________________ 297
Chapter 33 - Alterations of Cardiovascular Function _______________________ 309
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Chapter 34 - Alterations of Cardiovascular Function in Children ______________ 323
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Chapter 35 - Structure and Function of the Pulmonary System _______________ 331
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Chapter 36 - Alterations of Pulmonary Function __________________________ 341
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Chapter 37 - Alterations of Pulmonary Function in Children _________________ 357
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Chapter 38 - Structure and Function of the Renal and Urologic Systems ________ 365
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Chapter 39 - Alterations of Renal and Urinary Function _____________________ 375
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Chapter 40 - Alterations of Renal and Urinary Tract Function in Children ________ 385
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Chapter 41 - Structure and Function of the Digestive System ________________ 393
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Chapter 42 - Alterations of Digestive Function ___________________________ 404
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Chapter 43 - Alterations of Digestive Function in Children ___________________ 415
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Chapter 44 - Structure and Function of the Musculoskeletal System ___________ 424
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Chapter 45 - Alterations of Musculoskeletal Function ______________________ 436
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Chapter 46 - Alterations of Musculoskeletal Function in Children _____________ 448
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Chapter 47 - Structure Function and Disorders of the Integument _____________ 457
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Chapter 48 - Alterations of the Integument in Children ______________________ 468
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Chapter 49 - Shock Multiple Organ Dysfunction Syndrome and Burns in
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Adults _________________________________________________________ 476
Chapter 50 - Shock Multiple Organ Dysfunction Syndrome and Burns in
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Children ________________________________________________________ 483
, Chapter 01: Cellular Biology
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MULTIPLE CHOICE b
1. Which statement best describes the cellular function of metabolic absorption?
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a. Cells can produce proteins. b b b
b. Cells can secrete digestive enzymes. b b b b
c. Cells can take in and use nutrients. b b b b b b
d. Cells can synthesize fats. b b b
ANS: C b
In metabolic absorption, all cells take in and use nutrients and other substances from their
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surroundings. The remaining options are not inclusive in their descriptions of cellular
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metabolic absorption.
b b
PTS: b b 1 DIF: Cognitive Level: Remembering b b
2. Where is most of a cell’s genetic information, including RNA and DNA, contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C b
The nucleus contains the nucleolus, a small dense structure composed largely of RNA, most of the
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cellular DNA, and the DNA-binding proteins, such as the histones, which regulate its activity.
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The mitochondria are responsible for cellular respiration and energy production.
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Ribosomes’ chief function is to provide sites for cellular protein synthesis. Lysosomes function
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as the intracellular digestive system.
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PTS: b b 1 DIF: Cognitive Level: Remembering b b
3. Which component of the cell produces hydrogen peroxide (H2O2) by using oxygen to remove
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b hydrogen atoms from specific substrates in an oxidative reaction?
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a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B b
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