surname names
Number Number
Paper
B � �
Advanced
PAPER 1: Advanced Biochemistry, Microbiology
and Genetics
Instructions
• Use black ink or ball-point pen.
centre number and candidate number.
Answer the questions in the spaces provided
– there may be more space than you need.
Information
• The total mark for this paper is 90.
– use this as a guide as to how much time to spend on each question.
In question(s) marked with an asterisk (*), marks will be awarded for your ability
to structure your answer logically showing how the points that you make are
related or follow on from each other where appropriate.
Advice
• Read each question carefully before you start to answer it.
• Check your answers if you have time at the end.
Turn over
, Answer ALL questions.
Some questions must be answered with a cross in a box . If you change your mind about an
answer, put a line through the box and then mark your new answer with a cross .
1 Active transport is one type of cell transport mechanism.
(a) What happens during active transport?
(1)
A ATP is hydrolysed releasing energy
B ATP is hydrolysed using energy
C ATP is phosphorylated releasing energy
D ATP is phosphorylated using energy
(b) Which substance is transported against a concentration gradient by active
transport?
(1)
A hydrophilic molecule
B large hydrophobic molecule
C small hydrophobic molecule
D water
2
■■■■
, (c) The graph shows the change in concentration of molecule A and molecule B, as
they are transported into the cytoplasm of a cell.
molecule A
Concentration of molecules
in the cytoplasm molecule B
0 10 20 30
Time / mins
Explain the differences in the changes in concentration of molecule A and
molecule B between 0 and 10 minutes and between 20 and 30 minutes.
(2)
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
(Total for Question 1 = 4 marks)
3
■■■■ Turn over
, 2 The diagram shows part of cellular respiration.
glucose
glycolysis
X
link reaction
and
Krebs cycle
carbon dioxide
(a) Which is molecule X?
(1)
A glycerate 3-phosphate
B glycogen
C lactate
D pyruvate
(b) Which row of the table shows the locations of glycolysis, the link reaction and the
Krebs cycle in eukaryotic cells?
(1)
Glycolysis reaction cycle
A cytoplasm cytoplasm cytoplasm
B cytoplasm mitochondria mitochondria
C mitochondria cytoplasm cytoplasm
D mitochondria mitochondria mitochondria
4
■■■■
Number Number
Paper
B � �
Advanced
PAPER 1: Advanced Biochemistry, Microbiology
and Genetics
Instructions
• Use black ink or ball-point pen.
centre number and candidate number.
Answer the questions in the spaces provided
– there may be more space than you need.
Information
• The total mark for this paper is 90.
– use this as a guide as to how much time to spend on each question.
In question(s) marked with an asterisk (*), marks will be awarded for your ability
to structure your answer logically showing how the points that you make are
related or follow on from each other where appropriate.
Advice
• Read each question carefully before you start to answer it.
• Check your answers if you have time at the end.
Turn over
, Answer ALL questions.
Some questions must be answered with a cross in a box . If you change your mind about an
answer, put a line through the box and then mark your new answer with a cross .
1 Active transport is one type of cell transport mechanism.
(a) What happens during active transport?
(1)
A ATP is hydrolysed releasing energy
B ATP is hydrolysed using energy
C ATP is phosphorylated releasing energy
D ATP is phosphorylated using energy
(b) Which substance is transported against a concentration gradient by active
transport?
(1)
A hydrophilic molecule
B large hydrophobic molecule
C small hydrophobic molecule
D water
2
■■■■
, (c) The graph shows the change in concentration of molecule A and molecule B, as
they are transported into the cytoplasm of a cell.
molecule A
Concentration of molecules
in the cytoplasm molecule B
0 10 20 30
Time / mins
Explain the differences in the changes in concentration of molecule A and
molecule B between 0 and 10 minutes and between 20 and 30 minutes.
(2)
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . . .. . . .. . . . . . .. . . . .. . . . .. . . . .. . . . . ....... .... ... ... .... .
(Total for Question 1 = 4 marks)
3
■■■■ Turn over
, 2 The diagram shows part of cellular respiration.
glucose
glycolysis
X
link reaction
and
Krebs cycle
carbon dioxide
(a) Which is molecule X?
(1)
A glycerate 3-phosphate
B glycogen
C lactate
D pyruvate
(b) Which row of the table shows the locations of glycolysis, the link reaction and the
Krebs cycle in eukaryotic cells?
(1)
Glycolysis reaction cycle
A cytoplasm cytoplasm cytoplasm
B cytoplasm mitochondria mitochondria
C mitochondria cytoplasm cytoplasm
D mitochondria mitochondria mitochondria
4
■■■■
