NURS 3517 - TEST 2 FINAL EXAM |
ACCURATE CURRENTLY TESTING REAL
EXAM QUESTIONS WITH CORRECT
SOLUTIONS (100% CORRECT ANSWERS)
||GRADED A+|newest VERSION
Tricyclic Antidepressants (TCAs) - ANSWER ✓ • Have largely been replaced by
SSRIs as first-line antidepressant drugs
Monoamine Oxidase Inhibitors (MAOIs) - ANSWER ✓ • Rarely used for
depression
• Used for Parkinson's disease
MAOIs and Tyramine - ANSWER ✓ Ingestion of foods or drinks with tyramine
leads to hypertensive crisis, which may lead to cerebral hemorrhage, stroke, coma,
or death
CHARCUTERIE BOARDS ARE A NO GO
Serotonin Syndrome - ANSWER ✓ Central serotonin syndrome (CSS), as
evidenced by abdominal pain, diarrhea, sweating, fever, tachycardia, elevated
blood pressure, delirium, myoclonus, irritability, hyperpyrexia, and cardiovascular
shock.
• Signs and symptoms:
o anxiety
o agitation
o sweating, confusion
o tremors, restlessness
o lack of coordination
o rapid heart rate.
Newer-Generation Antidepressants: Drug Interactions - ANSWER ✓ • Are highly
bound to plasma proteins
,• Compete with other protein-binding drugs, resulting in more free, unbound drug
to cause a more pronounced drug effect
• Inhibit cytochrome P-450
• When combined with MAOIs, enhance serotonin activity resulting in
hyperthermia, diaphoresis, shivering, tremors, ataxia, and autonomic instability
Duloxetine Hydrochloride (Cymbalta®) - ANSWER ✓ Antidepressant
Treatment of major depressive disorder, management of neuropathic pain
associated with diabetic peripheral neuropathy, treatment of generalized anxiety
disorder, management of chronic musculoskeletal pain
Fluoxetine (Prozac) - ANSWER ✓ • SSRI
• Indications: Depression, bulimia, OCD, panic disorder, and premenstrual
dysphoric disorder
• Contraindications: known drug allergy and concurrent MAOI therapy
• Adverse effects: anxiety, dizziness, drowsiness, insomnia, and others
Mirtazapine (Remeron®) - ANSWER ✓ • Promotes the presynaptic release of
serotonin and norepinephrine in the brain
• Sedation
• Indications: depression (including that associated with BPD), sexual adverse
effects in male patients receiving SSRI therapy (reduction), and an appetite
stimulant
• Contraindications: drug allergy and MAOIs
• Adverse effects: drowsiness, abnormal dreams, dry mouth, constipation,
increased appetite, and asthenia
• Drug interactions: additive CNS depressant effects with alcohol and cytochrome
P-450
Antipsychotics - ANSWER ✓ • Drugs used to treat serious mental illness
Antipsychotic drugs MAO - ANSWER ✓ o Block dopamine receptors in the brain
(limbic system, basal ganglia), areas associated with emotion, cognitive function,
motor function
o Dopamine levels in the CNS are decreased.
o Result: tranquilizing effect in psychotic patients
Positive Symptoms of Schizophrenia - ANSWER ✓ • hallucinations, delusions,
and conceptual disorganization
, Negative Symptoms of Schizophrenia - ANSWER ✓ • apathy, social withdrawal,
blunted affect, poverty of speech, and catatonia
Antipsychotic Drugs: Adverse Effects - ANSWER ✓ Agranulocytosis and
hemolytic anemia
CNS effects
Drowsiness
Neuroleptic malignant syndrome (NMS)
Extrapyramidal symptoms (EPS): pseudoparkinsonism-akathisia, acute dystonia-
treated with benztropine (Cogentin) and trihexyphenidyl (Artane)
Tardive dyskinesia
Tardive dyskinesia - ANSWER ✓ involuntary movements of the facial muscles,
tongue, and limbs; a possible neurotoxic side effect of long-term use of
antipsychotic drugs that target certain dopamine receptors
Haloperidol - ANSWER ✓ -Antipsychotic
• Indications: long-term treatment of psychosis
• Contraindications: hypersensitivity, Parkinson's disease, large amounts of CNS
depressants taken
• Oral, intramuscular (LAI)
• Useful in treating patients with schizophrenia who were nonadherent to their drug
regimen
Atypical Antipsychotics: Mechanism of Action - ANSWER ✓ • Block specific
dopamine receptors: dopamine-2 (D2) receptors
• Also block specific serotonin receptors: serotonin-2 (5-HT2) receptors
This is responsible for their improved efficacy and safety profiles
Clozapine (Clozaril®) - ANSWER ✓ • Selectively blocks the dopaminergic
receptors in the mesolimbic region of the brain
• Associated with minor or no EPS
• Adverse effects: blood dyscrasias
Agranulocytosis r/t Clozapine - ANSWER ✓ • Neutrophil count (component of
white blood cells)
• Symptoms:
• Rapid onset of fever, chills, jaundice, weakness, or sore throat
ACCURATE CURRENTLY TESTING REAL
EXAM QUESTIONS WITH CORRECT
SOLUTIONS (100% CORRECT ANSWERS)
||GRADED A+|newest VERSION
Tricyclic Antidepressants (TCAs) - ANSWER ✓ • Have largely been replaced by
SSRIs as first-line antidepressant drugs
Monoamine Oxidase Inhibitors (MAOIs) - ANSWER ✓ • Rarely used for
depression
• Used for Parkinson's disease
MAOIs and Tyramine - ANSWER ✓ Ingestion of foods or drinks with tyramine
leads to hypertensive crisis, which may lead to cerebral hemorrhage, stroke, coma,
or death
CHARCUTERIE BOARDS ARE A NO GO
Serotonin Syndrome - ANSWER ✓ Central serotonin syndrome (CSS), as
evidenced by abdominal pain, diarrhea, sweating, fever, tachycardia, elevated
blood pressure, delirium, myoclonus, irritability, hyperpyrexia, and cardiovascular
shock.
• Signs and symptoms:
o anxiety
o agitation
o sweating, confusion
o tremors, restlessness
o lack of coordination
o rapid heart rate.
Newer-Generation Antidepressants: Drug Interactions - ANSWER ✓ • Are highly
bound to plasma proteins
,• Compete with other protein-binding drugs, resulting in more free, unbound drug
to cause a more pronounced drug effect
• Inhibit cytochrome P-450
• When combined with MAOIs, enhance serotonin activity resulting in
hyperthermia, diaphoresis, shivering, tremors, ataxia, and autonomic instability
Duloxetine Hydrochloride (Cymbalta®) - ANSWER ✓ Antidepressant
Treatment of major depressive disorder, management of neuropathic pain
associated with diabetic peripheral neuropathy, treatment of generalized anxiety
disorder, management of chronic musculoskeletal pain
Fluoxetine (Prozac) - ANSWER ✓ • SSRI
• Indications: Depression, bulimia, OCD, panic disorder, and premenstrual
dysphoric disorder
• Contraindications: known drug allergy and concurrent MAOI therapy
• Adverse effects: anxiety, dizziness, drowsiness, insomnia, and others
Mirtazapine (Remeron®) - ANSWER ✓ • Promotes the presynaptic release of
serotonin and norepinephrine in the brain
• Sedation
• Indications: depression (including that associated with BPD), sexual adverse
effects in male patients receiving SSRI therapy (reduction), and an appetite
stimulant
• Contraindications: drug allergy and MAOIs
• Adverse effects: drowsiness, abnormal dreams, dry mouth, constipation,
increased appetite, and asthenia
• Drug interactions: additive CNS depressant effects with alcohol and cytochrome
P-450
Antipsychotics - ANSWER ✓ • Drugs used to treat serious mental illness
Antipsychotic drugs MAO - ANSWER ✓ o Block dopamine receptors in the brain
(limbic system, basal ganglia), areas associated with emotion, cognitive function,
motor function
o Dopamine levels in the CNS are decreased.
o Result: tranquilizing effect in psychotic patients
Positive Symptoms of Schizophrenia - ANSWER ✓ • hallucinations, delusions,
and conceptual disorganization
, Negative Symptoms of Schizophrenia - ANSWER ✓ • apathy, social withdrawal,
blunted affect, poverty of speech, and catatonia
Antipsychotic Drugs: Adverse Effects - ANSWER ✓ Agranulocytosis and
hemolytic anemia
CNS effects
Drowsiness
Neuroleptic malignant syndrome (NMS)
Extrapyramidal symptoms (EPS): pseudoparkinsonism-akathisia, acute dystonia-
treated with benztropine (Cogentin) and trihexyphenidyl (Artane)
Tardive dyskinesia
Tardive dyskinesia - ANSWER ✓ involuntary movements of the facial muscles,
tongue, and limbs; a possible neurotoxic side effect of long-term use of
antipsychotic drugs that target certain dopamine receptors
Haloperidol - ANSWER ✓ -Antipsychotic
• Indications: long-term treatment of psychosis
• Contraindications: hypersensitivity, Parkinson's disease, large amounts of CNS
depressants taken
• Oral, intramuscular (LAI)
• Useful in treating patients with schizophrenia who were nonadherent to their drug
regimen
Atypical Antipsychotics: Mechanism of Action - ANSWER ✓ • Block specific
dopamine receptors: dopamine-2 (D2) receptors
• Also block specific serotonin receptors: serotonin-2 (5-HT2) receptors
This is responsible for their improved efficacy and safety profiles
Clozapine (Clozaril®) - ANSWER ✓ • Selectively blocks the dopaminergic
receptors in the mesolimbic region of the brain
• Associated with minor or no EPS
• Adverse effects: blood dyscrasias
Agranulocytosis r/t Clozapine - ANSWER ✓ • Neutrophil count (component of
white blood cells)
• Symptoms:
• Rapid onset of fever, chills, jaundice, weakness, or sore throat
