Chapter 15: skeletal system Questions and
Answers
standard indications for performing bone imaging include - ✅✅-staging of
malignant disease
-evaluation of primary bone metastases
-diagnosis of skeletal inflammatory disease
-evaluation of skeletal pain
-detection of occult fractures
most frequent indication for bone imaging - ✅✅staging and assessment of
treatment for malignant disease
Two RPs of choice for bone imaging - ✅✅Tc99m-MDP and Tc99m-HDP
MDP is aka - ✅✅aka medronate
HDP is aka - ✅✅aka oxidronate
medronate has been shown to have - ✅✅shown to have a faster blood
clearance than other labeled phosphate compounds
oxidronate has greater - ✅✅has greater bone uptake
, approximately 50% of the tracer is concentrated in - ✅✅concentrated in bone
tissue
the other 50% of tracer is excreted via - ✅✅excreted from the body via the
kidneys
localization of tracer in bone depends on - ✅✅depends on blood flow and the
rate of bone production or remodeling
blood flow is required to - ✅✅required to carry the RP to the bone where an
exchange between ions in the bone crystal and the tracer takes place
Hydroxyapatite chemical composition - ✅✅Ca10 (PO4) (OH)2
what is hydroxyapatite - ✅✅the inorganic compound that forms crystal
structures within bone
how does the bone tracer mechanism work - ✅✅phosphorus groups of the
tracer exchange onto the calcium of the hydroxyapatite crystal
Bone remodeling - ✅✅the destruction and replacement of bone
any process that increases osteoblastic activity causes - ✅✅causes increased
tracer uptake
Answers
standard indications for performing bone imaging include - ✅✅-staging of
malignant disease
-evaluation of primary bone metastases
-diagnosis of skeletal inflammatory disease
-evaluation of skeletal pain
-detection of occult fractures
most frequent indication for bone imaging - ✅✅staging and assessment of
treatment for malignant disease
Two RPs of choice for bone imaging - ✅✅Tc99m-MDP and Tc99m-HDP
MDP is aka - ✅✅aka medronate
HDP is aka - ✅✅aka oxidronate
medronate has been shown to have - ✅✅shown to have a faster blood
clearance than other labeled phosphate compounds
oxidronate has greater - ✅✅has greater bone uptake
, approximately 50% of the tracer is concentrated in - ✅✅concentrated in bone
tissue
the other 50% of tracer is excreted via - ✅✅excreted from the body via the
kidneys
localization of tracer in bone depends on - ✅✅depends on blood flow and the
rate of bone production or remodeling
blood flow is required to - ✅✅required to carry the RP to the bone where an
exchange between ions in the bone crystal and the tracer takes place
Hydroxyapatite chemical composition - ✅✅Ca10 (PO4) (OH)2
what is hydroxyapatite - ✅✅the inorganic compound that forms crystal
structures within bone
how does the bone tracer mechanism work - ✅✅phosphorus groups of the
tracer exchange onto the calcium of the hydroxyapatite crystal
Bone remodeling - ✅✅the destruction and replacement of bone
any process that increases osteoblastic activity causes - ✅✅causes increased
tracer uptake
