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Nuclear Medicine – Board Review 2025/2026 | 200+ Questions with Verified Answers | Radiopharmaceuticals, Imaging Protocols, Radiation Safety – Radiology

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This comprehensive nuclear medicine board review guide is tailored for students and professionals preparing for the 2025/2026 NMTCB or ARRT Nuclear Medicine Technology certification exams. It contains 200+ verified exam-style questions and answers, covering all essential nuclear medicine concepts with clinical precision and regulatory accuracy. This document goes far beyond basic practice exams—it's an in-depth resource for mastering advanced nuclear medicine principles, imaging protocols, and radiopharmacy. Core topics include: – Radiopharmaceuticals: detailed properties and uses of agents like Tc-99m, I-123, I-131, Ga-67, In-111, Y-90, F-18, Sm-153, and Sr-89 – Clinical Applications: brain perfusion, renal scans, cardiac shunt studies, GI bleeding localization, Meckel’s scan, bone scans, hepatobiliary and salivary imaging – Therapy and Oncology Imaging: Zevalin, Bexxar, MIBG, Xofigo, radioimmunotherapy – Radiation Safety & NRC Compliance: dose limits, medical event criteria, DOT labeling, radiation area signage, shielding, decay formulas – Instrumentation: dose calibrator QC, PET/SPECT principles, quality control, survey meters, energy resolution, collimation, and camera performance – Pharmacologic Agents: including adenosine, regadenoson, captopril, morphine, dobutamine, acetazolamide – CT Integration: low-dose CT parameters for hybrid PET/CT and SPECT/CT, technical factors like kVp, mAs, pitch, and reconstruction protocols Ideal for final board review, clinical rotations, or quick-reference use, the material is organized with concise explanations, formula breakdowns, and real-world scenarios that reflect current practice standards. Highly suited for students in: – Nuclear Medicine Technology programs – Radiologic and Diagnostic Imaging programs – PET/CT and SPECT/CT hybrid certification courses – Graduate-level Radiopharmacy or Radiation Safety coursework This resource is applicable across U.S. universities, teaching hospitals, and radiologic sciences institutions offering certification-track education in nuclear medicine. Keywords: nuclear medicine review, NMTCB board prep, radiopharmaceuticals, SPECT PET protocols, radiation safety, Tc99m agents, radionuclide therapy, image interpretation, dose calibrator QC, gamma camera, NRC regulations, CT imaging parameters, I-131 therapy, MIBG scan, In-111 octreotide, technologist exam

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Nuclear Medicine Board Review
2025/2026 Exam Questions and Correct
Answers | New Update



Gas Ventilation - 🧠 ANSWER ✔✔Xe 133, 81 KeV, 5.3 half life; reactor

produced

dose: 10-20 mCi

imaging: posterior position

negative pressure room required

uses activated charcoal trap to accumulate the exhaled xenon gas until

decayed to background

single breath: during inhalation

wash in / equilibrium : collected while the xenon distributes through aerated

portions of the lung

,wash out : while radioactivity is cleared from lungs


Sr 89 Chloride - 🧠 ANSWER ✔✔Strontium Chloride, Metastron


1.46 MeV max, .58 Mev mean

half life = 50.5 days

40-60 uci/kg IV

for skeletal mets, depresses bone marrow

shouldn't be used if leukocyte count below 2400/ul or platelet below

60,o00/ul

excretion : urinary


I 131 Tositumomab - 🧠 ANSWER ✔✔Bexxar


half life = 8.04 days

606.3 KeV max energy

treatment of patients with NHL

before treatment, patient must receive 650 mg acetaminophen and 50mg

diphydramine orally

thyroid uptake should be minimized with SSKI

,activity initially seen in blood pool, liver and spleen

later times, activity in liver, spleen, thyroid, bladder, and tumor sites


Y 90 ibritumomab tiuxtetan - 🧠 ANSWER ✔✔Zevalin


half life = 2.67 days

2.281 MeV

treatment of patients with NHL (disseminated follicular B-Cell)

monoclonal antibody against lymphoma antigens

before treatment, patient must receive 650 mg (imaging) acetaminophen

and 50mg diphydramine orally

max dose = 32 mci

platelets must be at least 100,000/mm3


Sm 153 EDTMP - 🧠 ANSWER ✔✔ethylenediaminetetra methylene

phosphonic

Quadramet

half life = 46.7 hours

0.81 MeV maximum



COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
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, concentrates in bone marrow

for patients with more metabolically activate metastases from prostate or

breast cancer, as well as those from osteogenic sarcoma

1.0mci/kg

urinary excretion


Bone therapy blood requirements - 🧠 ANSWER ✔✔60,000-100,000/ul

platelet

2400-3000/ul leukocyte

2000/ul granuolyte


I 131 MIBG - 🧠 ANSWER ✔✔metaiodobenzylguanidine


half life = 8.06 days

localization/treatment of primary or metastatic pheochromocytomas/

neuroblastoma

8.04 days

kidney/ urinary excretion


I 131 Sodium Iodide - 🧠 ANSWER ✔✔half life = 8.06 days

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