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Atrophy - 🧠 ANSWER ✔✔E. Cells decrease in size
P. Still functional
Physiologic: thymus gland in early childhood
Pathological: disuse
Hypertrophy - 🧠 ANSWER ✔✔E. Increase in cell size
P. Increased workload
Physiologic: weightlifting
Pathologic: cardiomegaly from HTN
Hyperplasia - 🧠 ANSWER ✔✔E. Increase in cell number
P. Increased cellular division
,Physiologic: liver regeneration
Pathologic: endometrial- usually r/t hormones
Dysplasia - 🧠 ANSWER ✔✔E. Cells change in size, shape, organization
P. AKA atypical hyperplasia, a disorderly proliferation
Physiologic: N/A
Pathologic: squamous dysplasia of cervix from HPV
Metaplasia - 🧠 ANSWER ✔✔E. one cell type replaced with another
P. reprogramming of stem cells, reversible
Physiologic: N/A
Pathologic: stratified squamous cells in bronchial lining r/t cigarette smoke
Hypoxia injury - 🧠 ANSWER ✔✔E. inadequate oxygenation of tissues
P. decrease in mitochondrial function, decreased production of ATP
increases anaerobic metabolism. eventual cell death.
C.M. hypoxia, cyanosis, cognitive impairment, lethargy
, Free radical and ROS - 🧠 ANSWER ✔✔E. normal byproduct of ATP
production, will overwhelm the mitochondria- exhaust intracellular
antioxidants
P. lipid peroxidation, damage proteins, fragment DNA
C.M. development in Alzheimer's, heart disease, Parkinson's disease,
Amyotrophic Lateral Sclerosis
Ethanol - 🧠 ANSWER ✔✔E. mood altering drug, long term effects on liver
and nutritional status
P. metabolized by liver, generates free radicals
C.M. CNS depression, nutrient deficiencies-Mag, Vit B6, thiamine, PO4,
inflammation and fatty infiltration of liver, hepatomegaly, leads to liver
failure irreversible
Oncosis - 🧠 ANSWER ✔✔Na and H2O enter cell and cause swelling.
Organ increases in weight, becomes distended and pale. Associated with
high fever, hypocalcemia, certain infections
Fatty Infiltration - 🧠 ANSWER ✔✔intracellular accumulation of lipids in the
liver
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