9/26/25, 3:55 PM Histology NBME full questions <span style="color:#000;font-weight:bold;">350+</span> (2025-2026 A+ Graded) Exam-Style Questi…
NBME Histology Exam Questions and
Answers
Question 1
Nuclear pores:
A)Combine to form a hexagonal structure
B)Have 50nm in diameter
C)Their number is not connected with cellular activity
D)Nuclear lamina are connected to their inner rings
E)A and C are correct
F)B and D are correct
Correct Answer
E)A and C are correct
Question 2
The conducting zone of the respiratory system:
A) Includes the upper airways, trachea and the bronchial tree (including the terminal
bronchioles)
B) Is designed for airflow and respiration
C) Includes only the nose and the pharynx
D) Is designed for olfactory
E) A and C are correct
F) B and D are correct
Correct Answer
A) Includes the upper airways, trachea and the bronchial tree (including the terminal
bronchioles)
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,9/26/25, 3:55 PM Histology NBME full questions <span style="color:#000;font-weight:bold;">350+</span> (2025-2026 A+ Graded) Exam-Style Questi…
Question 3
***The bronchial tree starts with the primary bronchi:
A)And ends with the respiratory bronchioles
B) And on each section is lined with the simple columnar epithelium
C) And is composed of submucosa with plates of fibrocartilage
D) And is part of the conducting portion
E) A and C are correct
F) B and D are correct
Correct Answer
D) And is part of the conducting portion
Question 4
***The feature of skeletal muscles is:
A) Composed of mononucleated cells
B) Have myofibrils that does not possess A bands
C) Are composed of bundles of multinucleated fibers
D) Their contraction is slow and not subject to voluntary control
E) A and C are correct
F) B and D are correct
Correct Answer
C) Are composed of bundles of multinucleated fibers
Question 5
***In the skeletal muscle thin filaments are composed of:
A) Actin
B) Myosin
C) Tropomyosin
D) Light and heavy chains
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
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,9/26/25, 3:55 PM Histology NBME full questions <span style="color:#000;font-weight:bold;">350+</span> (2025-2026 A+ Graded) Exam-Style Questi…
Question 6
***The contraction of skeletal muscle requires:
A) GTP
B) ATP
C) Mg ions
D) Ca ions
E) A and C are correct
F) B and D are correct
Correct Answer
F) B and D are correct
Question 7
***Sarcomere:
A) Is the basic contractile unit of skeletal muscle
B) Is the basic contractile unit of smooth muscle
C) Consist of thick and thin filaments
D) Extends from A band to M line
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
Question 8
***What cell type secretes ACTH?
A) Lactotropic cells
B) Thyrotropic cells
C) Somatotropic cells
D) Corticotropic cells
E) A and C are correct
F) B and D are correct
Correct Answer
D) Corticotropic cells
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, 9/26/25, 3:55 PM Histology NBME full questions <span style="color:#000;font-weight:bold;">350+</span> (2025-2026 A+ Graded) Exam-Style Questi…
Question 9
***Which of the following phrases concerning osteocytes are correct:
A) Oval active cells
B) Placed in Howship's lacunae
C) Secrete osteoid
D) Almond-shaped cells
E) A and C are correct
F) B and D are correct
Correct Answer
D) Almond-shaped cells
Question 10
***Periosteum consists of:
A) Outer layer of collagen fibers and fibroblasts
B) Outer layer of osteoprogenitor cells
C) Inner layer of osteoprogenitor cells
D) Inner layer of collagen fibers and fibroblasts
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
Question 11
***Which of the following phrases concerning intramembranous ossification are
correct:
A) Is source of most of the flat bones
B) Is source of most of the long bones
C) Begins from mesenchymal condensation
D) Starts from the bone collar formation
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
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NBME Histology Exam Questions and
Answers
Question 1
Nuclear pores:
A)Combine to form a hexagonal structure
B)Have 50nm in diameter
C)Their number is not connected with cellular activity
D)Nuclear lamina are connected to their inner rings
E)A and C are correct
F)B and D are correct
Correct Answer
E)A and C are correct
Question 2
The conducting zone of the respiratory system:
A) Includes the upper airways, trachea and the bronchial tree (including the terminal
bronchioles)
B) Is designed for airflow and respiration
C) Includes only the nose and the pharynx
D) Is designed for olfactory
E) A and C are correct
F) B and D are correct
Correct Answer
A) Includes the upper airways, trachea and the bronchial tree (including the terminal
bronchioles)
Page 1 of 116
1/116
,9/26/25, 3:55 PM Histology NBME full questions <span style="color:#000;font-weight:bold;">350+</span> (2025-2026 A+ Graded) Exam-Style Questi…
Question 3
***The bronchial tree starts with the primary bronchi:
A)And ends with the respiratory bronchioles
B) And on each section is lined with the simple columnar epithelium
C) And is composed of submucosa with plates of fibrocartilage
D) And is part of the conducting portion
E) A and C are correct
F) B and D are correct
Correct Answer
D) And is part of the conducting portion
Question 4
***The feature of skeletal muscles is:
A) Composed of mononucleated cells
B) Have myofibrils that does not possess A bands
C) Are composed of bundles of multinucleated fibers
D) Their contraction is slow and not subject to voluntary control
E) A and C are correct
F) B and D are correct
Correct Answer
C) Are composed of bundles of multinucleated fibers
Question 5
***In the skeletal muscle thin filaments are composed of:
A) Actin
B) Myosin
C) Tropomyosin
D) Light and heavy chains
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
Page 2 of 116
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,9/26/25, 3:55 PM Histology NBME full questions <span style="color:#000;font-weight:bold;">350+</span> (2025-2026 A+ Graded) Exam-Style Questi…
Question 6
***The contraction of skeletal muscle requires:
A) GTP
B) ATP
C) Mg ions
D) Ca ions
E) A and C are correct
F) B and D are correct
Correct Answer
F) B and D are correct
Question 7
***Sarcomere:
A) Is the basic contractile unit of skeletal muscle
B) Is the basic contractile unit of smooth muscle
C) Consist of thick and thin filaments
D) Extends from A band to M line
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
Question 8
***What cell type secretes ACTH?
A) Lactotropic cells
B) Thyrotropic cells
C) Somatotropic cells
D) Corticotropic cells
E) A and C are correct
F) B and D are correct
Correct Answer
D) Corticotropic cells
Page 3 of 116
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, 9/26/25, 3:55 PM Histology NBME full questions <span style="color:#000;font-weight:bold;">350+</span> (2025-2026 A+ Graded) Exam-Style Questi…
Question 9
***Which of the following phrases concerning osteocytes are correct:
A) Oval active cells
B) Placed in Howship's lacunae
C) Secrete osteoid
D) Almond-shaped cells
E) A and C are correct
F) B and D are correct
Correct Answer
D) Almond-shaped cells
Question 10
***Periosteum consists of:
A) Outer layer of collagen fibers and fibroblasts
B) Outer layer of osteoprogenitor cells
C) Inner layer of osteoprogenitor cells
D) Inner layer of collagen fibers and fibroblasts
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
Question 11
***Which of the following phrases concerning intramembranous ossification are
correct:
A) Is source of most of the flat bones
B) Is source of most of the long bones
C) Begins from mesenchymal condensation
D) Starts from the bone collar formation
E) A and C are correct
F) B and D are correct
Correct Answer
E) A and C are correct
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