NSG 555 Midterm Study Guide – Questions With
Exact Solutions
Save
Practice questions for this set
Learn 1 /7 Study with Learn
- decreased iron, B12, and calcium absorption
- Increased constipation
Choose an answer
Pharm implications in older adult:
1 Pharmacokinetics 2
GI
Smoking and Theophylline PPIs, antacids, increase gastric pH
3 4
clearance leading to:
Don't know?
Terms in this set (63)
The process by which drugs are absorbed,
Pharmacokinetics distributed within the body, metabolized, and
excreted.
, Pharmacodynamics what the drug does to the body
Drug that undergoes Nitrates
extensive first-pass effect
Fluoroquinolones (Cipro) Divalent cations (Ca, Mg, Fe)
are reduced when taken - found in antacids, dairy products, MVI
with:
PPIs, antacids, increase - Increased: Nifedipine and Amoxicillin
gastric pH leading to: - Decreased: Imidazole, antifungals, Inidavanir
water-soluble
- decreased distribution in older adults (less body
hydrophilic drugs
water)
- ethanol, lithium
fat-soluble
- increased distribution in older adults (greater fat
lipophilic drugs
stores)
- diazepam, flurazepam, trazodone
- binds to skeletal muscle; reduced volume in older
Digoxin binding
adults because of reduced muscle mass
Reduced hydroxylation, oxydation, dealkylation
- converted to metabolites of lesser, equal, or
Metabolism: Phase I
greater pharmacologic effect than parent
Pathway
compound
ex: diazepam
Glucuronidation, conjugation, acetylation
- preferred pathway for older adults; metabolites
Metabolism: Phase II
aren't as active and don't accumulate
Pathway
- ex: lorazepam is converted to inactive compound
in older adults
Oxazepam metabolized faster in older men than women
Nefazodone concentrations are 50% greater in older women
Smoking and Smoking stimulates mooxygenase enzymes leading
Theophylline clearance to increased theophylline clearance
Cockcroft-Gault equation ((140-age) x kg) / (72 x SCr)) x 0.85 for women.
Exact Solutions
Save
Practice questions for this set
Learn 1 /7 Study with Learn
- decreased iron, B12, and calcium absorption
- Increased constipation
Choose an answer
Pharm implications in older adult:
1 Pharmacokinetics 2
GI
Smoking and Theophylline PPIs, antacids, increase gastric pH
3 4
clearance leading to:
Don't know?
Terms in this set (63)
The process by which drugs are absorbed,
Pharmacokinetics distributed within the body, metabolized, and
excreted.
, Pharmacodynamics what the drug does to the body
Drug that undergoes Nitrates
extensive first-pass effect
Fluoroquinolones (Cipro) Divalent cations (Ca, Mg, Fe)
are reduced when taken - found in antacids, dairy products, MVI
with:
PPIs, antacids, increase - Increased: Nifedipine and Amoxicillin
gastric pH leading to: - Decreased: Imidazole, antifungals, Inidavanir
water-soluble
- decreased distribution in older adults (less body
hydrophilic drugs
water)
- ethanol, lithium
fat-soluble
- increased distribution in older adults (greater fat
lipophilic drugs
stores)
- diazepam, flurazepam, trazodone
- binds to skeletal muscle; reduced volume in older
Digoxin binding
adults because of reduced muscle mass
Reduced hydroxylation, oxydation, dealkylation
- converted to metabolites of lesser, equal, or
Metabolism: Phase I
greater pharmacologic effect than parent
Pathway
compound
ex: diazepam
Glucuronidation, conjugation, acetylation
- preferred pathway for older adults; metabolites
Metabolism: Phase II
aren't as active and don't accumulate
Pathway
- ex: lorazepam is converted to inactive compound
in older adults
Oxazepam metabolized faster in older men than women
Nefazodone concentrations are 50% greater in older women
Smoking and Smoking stimulates mooxygenase enzymes leading
Theophylline clearance to increased theophylline clearance
Cockcroft-Gault equation ((140-age) x kg) / (72 x SCr)) x 0.85 for women.
