Advanced Pathophysiology (NR507) –
Midterm Exam (2025/2026 Update) |
Chamberlain University – Complete
Exam Material
The NR507 Advanced Pathophysiology Midterm Exam at Chamberlain University assesses key
concepts in cellular biology, inflammation, immune responses, hematology, cardiovascular,
pulmonary, and renal pathophysiology. This exam includes 50 questions (multiple-choice and
select-all-that-apply) aligned with the 2025/2026 curriculum, Pathophysiology: The Biologic
Basis for Disease in Adults and Children (McCance & Huether, 8th ed., 2021), Chamberlain
resources, and HESI-style question banks. Each question is worth 5 points (total 250 points); aim
for ≥80% (40/50 correct) for a passing score. Answers are in blue, with concise rationales for
mastery. Focus on disease mechanisms, clinical manifestations, and evidence-based applications.
Question 1: What is the most abundant plasma protein?
Answer: Albumin
Rationale: Albumin (~60%, 4 g/dL) maintains oncotic pressure and transports substances.
Question 2: Which is NOT a major drug-resistant strain of Neisseria gonorrhoeae?
Answer: Chromosomal control of resistance (CMRNG)
Rationale: PPNG, TRNG, QRNG are primary concerns; CMRNG is less significant.
Question 3: The Schilling test assesses:
Answer: Vitamin B12 absorption
Rationale: Measures urinary excretion of radioactive B12 to diagnose pernicious anemia.
Question 4: If the SA node fails, the heart’s pacemaker is:
Answer: AV node
Rationale: AV node paces at 40-60 bpm if SA node is damaged.
, Question 5: Anaphylaxis is classified as:
Answer: Type I hypersensitivity
Rationale: IgE-mediated mast cell degranulation causes systemic allergic reactions.
Question 6: What is an undifferentiated cell capable of infinite division?
Answer: Stem cell
Rationale: Stem cells are pluripotent, capable of self-renewal and differentiation.
Question 7: The process of stem cell division is called:
Answer: Cell cycle
Rationale: Includes G1, S, G2, and M phases; ~24-hour cycle.
Question 8: A common event in cellular reproduction leading to cancer cells is:
Answer: Cell transformation
Rationale: Genetic mutations cause uncontrolled proliferation.
Question 9: Microcytic anemia is defined by:
Answer: MCV <80 fL
Rationale: Small RBCs; seen in iron deficiency, thalassemia.
Question 10: Macrocytic anemia is defined by:
Answer: MCV >100 fL
Rationale: Large RBCs; linked to B12/folate deficiency.
Question 11: Hypochromic anemia is characterized by:
Answer: Low MCHC
Rationale: Pale RBCs due to reduced hemoglobin.
Question 12: Hyperchromic anemia involves:
Answer: High MCHC
Rationale: Dark RBCs with increased hemoglobin.
Midterm Exam (2025/2026 Update) |
Chamberlain University – Complete
Exam Material
The NR507 Advanced Pathophysiology Midterm Exam at Chamberlain University assesses key
concepts in cellular biology, inflammation, immune responses, hematology, cardiovascular,
pulmonary, and renal pathophysiology. This exam includes 50 questions (multiple-choice and
select-all-that-apply) aligned with the 2025/2026 curriculum, Pathophysiology: The Biologic
Basis for Disease in Adults and Children (McCance & Huether, 8th ed., 2021), Chamberlain
resources, and HESI-style question banks. Each question is worth 5 points (total 250 points); aim
for ≥80% (40/50 correct) for a passing score. Answers are in blue, with concise rationales for
mastery. Focus on disease mechanisms, clinical manifestations, and evidence-based applications.
Question 1: What is the most abundant plasma protein?
Answer: Albumin
Rationale: Albumin (~60%, 4 g/dL) maintains oncotic pressure and transports substances.
Question 2: Which is NOT a major drug-resistant strain of Neisseria gonorrhoeae?
Answer: Chromosomal control of resistance (CMRNG)
Rationale: PPNG, TRNG, QRNG are primary concerns; CMRNG is less significant.
Question 3: The Schilling test assesses:
Answer: Vitamin B12 absorption
Rationale: Measures urinary excretion of radioactive B12 to diagnose pernicious anemia.
Question 4: If the SA node fails, the heart’s pacemaker is:
Answer: AV node
Rationale: AV node paces at 40-60 bpm if SA node is damaged.
, Question 5: Anaphylaxis is classified as:
Answer: Type I hypersensitivity
Rationale: IgE-mediated mast cell degranulation causes systemic allergic reactions.
Question 6: What is an undifferentiated cell capable of infinite division?
Answer: Stem cell
Rationale: Stem cells are pluripotent, capable of self-renewal and differentiation.
Question 7: The process of stem cell division is called:
Answer: Cell cycle
Rationale: Includes G1, S, G2, and M phases; ~24-hour cycle.
Question 8: A common event in cellular reproduction leading to cancer cells is:
Answer: Cell transformation
Rationale: Genetic mutations cause uncontrolled proliferation.
Question 9: Microcytic anemia is defined by:
Answer: MCV <80 fL
Rationale: Small RBCs; seen in iron deficiency, thalassemia.
Question 10: Macrocytic anemia is defined by:
Answer: MCV >100 fL
Rationale: Large RBCs; linked to B12/folate deficiency.
Question 11: Hypochromic anemia is characterized by:
Answer: Low MCHC
Rationale: Pale RBCs due to reduced hemoglobin.
Question 12: Hyperchromic anemia involves:
Answer: High MCHC
Rationale: Dark RBCs with increased hemoglobin.
