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Pharmacology Unit 1 – NU 578 Exam Questions and Answers 2025/2026 – Drug Metabolism, Receptor Types, P450 System, Routes of Administration & Pediatric Pharmacokinetics

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This Pharmacology Unit 1 Exam Review for NU 578 (2025/2026) contains 100+ verified, high-yield questions and correct answers, curated to support graduate-level students preparing for midterms, finals, or licensure exams. The guide provides a strong foundational understanding of pharmacologic principles, mechanisms, and clinical implications—essential for advanced nursing, pharmacy, or physician assistant training. Topics are thoroughly covered in Q&A format, including: Pharmacokinetics and metabolism: absorption, distribution, metabolism, and excretion (ADME), P450 enzyme system, renal clearance, half-life Receptor pharmacology: muscarinic, nicotinic, adrenergic (alpha-1, beta-1, beta-2), agonists vs antagonists Routes of administration and bioavailability: IM, IV, oral, subcutaneous, and first-pass effect Toxicology and drug interactions: QT prolongation, hepatotoxicity, metabolic and pharmacodynamic tolerance Clinical pharmacology in special populations: neonates, infants, elderly, and pregnant patients Drug classification and regulation: FDA schedules (I–V), clinical trial phases, placebo effect Pathophysiological drug effects: e.g., Myasthenia Gravis, malignant hyperthermia, neuromuscular blockers, cholinesterase inhibitors Critical thinking in adverse drug reactions, ion trapping, lipid solubility, and therapeutic index This study resource is ideal for: Graduate nursing students (MSN, DNP) Medical, pharmacy, or PA students taking advanced pharmacology Instructors seeking vetted exam material for advanced coursework Students reviewing for boards, ANCC, AANP, or pharmacology certification exams Every answer is precise, clinically relevant, and mapped to real-world pharmacologic applications, helping learners move beyond memorization into applied understanding. Keywords: NU 578, pharmacology exam, drug metabolism, hepatic clearance, enzyme inducers, P450 system, receptor pharmacology, adrenergic drugs, cholinergic pathways, QT prolongation, drug toxicity, pediatric pharmacokinetics, half-life, drug absorption, clinical trials, FDA schedules, neuromuscular blockers, advanced nursing pharmacology

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Pharmacology-- NU 578--Unit 1--#2
2025/2026 Exam Questions and Verified
Answers | Already Graded A+



Full term - 🧠 ANSWER ✔✔36-40 weeks gestation


Ganglionic blocking agents - 🧠 ANSWER ✔✔Interrupt impulse transmission

through ganglia of the autonomic nervous system. They do this by

competing with Ach for binding to nicotinic receptors in autonomic ganglia.


Generic name - 🧠 ANSWER ✔✔Assigned by US Adopted Names Council. -

each drug has only ONE -aka nonproprietary name or US Adopted Name


Glomerular filtration - 🧠 ANSWER ✔✔Moves drugs from the blood into the

tubular urine within the glomerulus of the Bowman's capsule.

,Half life - 🧠 ANSWER ✔✔The time it takes for a drug to be 50% of its

original concentration in the body. The time required for the amount of dug

in the body to decrease by 50%.


Hepatic metabolism - 🧠 ANSWER ✔✔Is low in newborns.


Hepatic microsomal enzyme system - 🧠 ANSWER ✔✔a.k.a. P450 system

which an enzyme system consisting of 12 closely enzyme families in the

liver involved with metabolizing drugs. Cyochrome P450 is a key

component of the system. These enzymes are capable of catalyzing a wide

variety of reactions using drugs as substrate.


Hepatotoxic drugs - 🧠 ANSWER ✔✔Drugs that cause injury to the liver.

Patients taking these should have liver function tests to check liver

enzymes: aspartate aminotransferase (AST, formerly known as SGOT) and

alanine aminotransferase (ALT, formerly known as SGPT).


Iatrogenic disease - 🧠 ANSWER ✔✔A disease produced by drugs.


Idiosyncratic effect - 🧠 ANSWER ✔✔An uncommon drug response resulting

from a genetic predisposition.

, Inactivation - 🧠 ANSWER ✔✔Drug metabolism can convert

pharmacologically active compounds to inactive forms.


Induction - 🧠 ANSWER ✔✔The process of stimulating liver enzyme

synthesis to increase the drug-metabolizing capacity of the liver.


Infants - 🧠 ANSWER ✔✔weeks 5-52


Intramuscular administration - 🧠 ANSWER ✔✔Absorption pattern: rapidly or

slowly depending on the water solubility of the drug and blood flow to the

site


Advantages to IM administration - 🧠 ANSWER ✔✔Administration of poorly

soluble drugs, administration of depot preparations which absorb slowly.


Barriers to IM administration - 🧠 ANSWER ✔✔capillary walls


Disadvantages to IM administration - 🧠 ANSWER ✔✔Discomfort and

inconvenience, can't be used on patients on anticoagulant therapy.


IM administration - 🧠 ANSWER ✔✔Slow & erratic in neonates, rapid in

infants.


IV adminstration - 🧠 ANSWER ✔✔Absorption pattern: instantaneous and

complete

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