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NU 578 Controlled Substances Final Exam 2025/2026 – 200+ Verified Questions and Answers | Opioid Management, DEA Schedules, Tolerance, Dependence, REMS, Pain Pharmacology

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This document contains over 200 verified and up-to-date exam questions and answers for the NU 578 Controlled Substances Final Exam for the 2025/2026 academic year. Designed for graduate-level nursing and advanced practice students, it provides a comprehensive overview of controlled substance pharmacology and regulatory knowledge essential for safe and compliant prescribing. It covers a wide array of clinical and legal topics, including: Opioid classifications and actions (full agonists, partial agonists, antagonists) Controlled substance schedules (I–V) under the Controlled Substances Act (CSA) Tolerance, dependence, addiction, and withdrawal differentiation Use of methadone, fentanyl, buprenorphine, tramadol, and meperidine REMS (Risk Evaluation and Mitigation Strategy) programs and black box warnings Diagnostic and monitoring tools such as ORT, SOAPP, PMQ, and COMM Drug safety concerns, such as opioid-induced hyperalgesia, MAOI interactions, and sedative synergy DEA prescribing limits, prescription regulations, and state vs federal rules Safe prescribing practices across populations (pregnant, elderly, chronic pain patients) The guide also explores equianalgesic conversions, PRN vs scheduled dosing, abuse-deterrent formulations, PDMP requirements, and key CDC and DEA guidelines applicable to clinical practice. This resource is highly valuable for: MSN, DNP, APRN, and FNP students Nurse practitioners preparing for state and federal controlled substance certification Healthcare professionals pursuing CME or CEU credits Clinical instructors and pharmacology educators Whether you're preparing for your final exam or building long-term prescribing competence, this document ensures thorough coverage of both pharmacologic knowledge and prescriber responsibilities. Keywords: controlled substances final, NU 578 exam questions, opioid classification, DEA schedule drugs, benzodiazepine pharmacology, REMS requirements, addiction vs dependence, opioid withdrawal, methadone safety, equianalgesic dosing, PDMP use, DEA certification, Suboxone regulations, CNS depressants, MAOI interactions, controlled prescription guidelines, nurse practitioner pharmacology, APRN opioid education, pain management laws, CDC opioid guide

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Uploaded on
September 16, 2025
Number of pages
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Written in
2025/2026
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NU 578 Controlled Substances
2025/2026 Exam Questions with 100%
Correct Answers | Latest Update



abused prescription drug, second-most - 🧠 ANSWER ✔✔codeine


Act also known as the Controlled Substance Act (1970) - 🧠 ANSWER

✔✔Comprehensive Drug Abuse Prevention and Control Act


actiq - 🧠 ANSWER ✔✔transmuscosal fentanyl only approved for

breakthrough cancer pain in opioid tolerant patients

addictive drugs all activate the brain's _________ - 🧠 ANSWER

✔✔dopamine reward circuit


after detox, an opioid addict can be rx'd ___________ to discourage

renewed opioid abuse - 🧠 ANSWER ✔✔naltrexone


AIDS patients use Dronabinol (marinol) - 🧠 ANSWER ✔✔for appetite stim

,alvimopan - 🧠 ANSWER ✔✔used for tx of opioid-induced ileus


amphetamines are schedule - 🧠 ANSWER ✔✔II


amphetamines work primarily by promoting neuronal release of _________

& ___________, and partly by blocking their reuptake - 🧠 ANSWER

✔✔norepinephrine; dopamine


amphetamines, most common adverse effects - 🧠 ANSWER ✔✔insomnia;

weight loss


analgesics, most effective available - 🧠 ANSWER ✔✔opioids


avinza - 🧠 ANSWER ✔✔extended release morphine


barbiturate OD antidote? - 🧠 ANSWER ✔✔none, just supportive treatment


barbiturate OD produces same classic triad of symptoms (resp. depression,

coma, pinpoint pupils) as seen with - 🧠 ANSWER ✔✔opioid OD


barbiturate tolerant individuals are cross-tolerant to other CNS depressants

(alcohol, benzos, general anesthetics) but not with ________ - 🧠 ANSWER

✔✔opioids

, behavior pattern characterized by continued use of a psychoactive

substance despite physical, psychologic, or social harm - 🧠 ANSWER

✔✔addiction


benzodiazepine principal indications are - 🧠 ANSWER ✔✔anxiety,

insomnia, seizure disorders


benzodiazepines adverse effects - 🧠 ANSWER ✔✔daytime sedation;

anterograde amnesia


benzodiazepines are classified as Schedule - 🧠 ANSWER ✔✔IV


benzodiazepines are primarily for which two anxiety d/o's - 🧠 ANSWER

✔✔panic disorder, GAD


benzodiazepines produce their actions by enhancing the effects of _____,

the principal inhibitory neurotransmitter in the CNS - 🧠 ANSWER ✔✔GABA


benzodiazepines-like controlled substace approved for long-term use in

insomnia - 🧠 ANSWER ✔✔eszopiclone (Lunesta)


black box warnings - 🧠 ANSWER ✔✔a component of REMS




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