Controlled Substances Unit 2- NU 578
2025/2026 Exam Questions and Correct
Answers | New Update
Morphine (standard) - 🧠 ANSWER ✔✔Relieve pain, causes drowsiness and
mental clouding, reduces anxiety and creates a sense of well-being
o Actions through CNS and peripherycan cause resp depression,
constipation, urinary retention, orthostatic hypotension, emesis, miosis
(pinpoint pupils), cough
suppression, and biliary colic
o Relieves pain w/o affecting other senses or LOC
o Large doses affective against sharp pain
o ability to cause mental clouding, sedation, euphoria, and anxiety
reduction can contribute to pain relief.
,Morphine actions: - 🧠 ANSWER ✔✔Analgesia, eurpohia, sedation, cough
suppression, biliary colic, emesis, elevated ICP, Miosis, Neurotoxicity,
Hormonal changes w prolonged use.
Adverse affects of Morphine - 🧠 ANSWER ✔✔Resp Depression
Tolerance to resp depression-long term use
When to NOT give Morphine: - 🧠 ANSWER ✔✔elderly/young (monitor)
Hx of Resp disease (COPD/Asthma)
Concurrent with CNS depressant
RR less than 12
*REVERSE WITH NARCAN*
Morphine depression varies by route: - 🧠 ANSWER ✔✔IV 7 min
IM 30 min
SQ 90 min
Spinal 4-5 hours
,Morphine S/E: Constipation tx - 🧠 ANSWER ✔✔Activation of mu receptors
of the gut, suppress propulsive intestinal contractions, intensify
nonpropulsive contractions, increase the tone of the anal sphincter,
inhibit secretion of fluid into the intestinal lumen
AEfecal impaction, bowel perf, rectal tearing, hemorrhoids
Prophylactic drugs for constipation - 🧠 ANSWER ✔✔stimulant lax- senna
polyethylene glycol (osmotic lax)
lactulose/sodium phosphate
methylnaltrexone (Relistor) aka: rescue therapy
Morphine Side effect: Orthostatic hypotension - 🧠 ANSWER ✔✔o R/t the
blunting of the baroreceptor relex and dilating peripheral arterioles and
veins. Causes the release of histamine
Morphine: urinary retention-- 3 mechanisms - 🧠 ANSWER ✔✔Increases
tone in the bladder sphincter
Increases tone in the detrusor muscle thereby elevating pressure within
the bladder causing a sense of urinary urgency
Interfere w voiding by suppressing awareness of bladder stimuli
COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED
, Tx of urinary retention with morphine - 🧠 ANSWER ✔✔encourage urination
q 4 hours
Hesitancy and retention esp likely in pt w BPH and drugs with
anticholinergic properties (tricyclic antidepressants, antihistamines) can
exacerbate the
prob
Morphine also used as - 🧠 ANSWER ✔✔Cough suppression
o Act at opioid receptors in the medulla
Morphine: side effect: Biliary colic - 🧠 ANSWER ✔✔Biliary Colic
o Induce spasm of the common bile duct, causing pressure w/in the biliary
tract to rise dramatically
Symptoms epigastric distress to biliary colic
Certain opioids cause less smooth muscle spam r/t morhpine admin? - 🧠
ANSWER ✔✔Demerol
Morphine side effect: emesis - 🧠 ANSWER ✔✔Emesis
o Caused by direct stimulation of the chemoreceptor trigger zone of the
medulla
2025/2026 Exam Questions and Correct
Answers | New Update
Morphine (standard) - 🧠 ANSWER ✔✔Relieve pain, causes drowsiness and
mental clouding, reduces anxiety and creates a sense of well-being
o Actions through CNS and peripherycan cause resp depression,
constipation, urinary retention, orthostatic hypotension, emesis, miosis
(pinpoint pupils), cough
suppression, and biliary colic
o Relieves pain w/o affecting other senses or LOC
o Large doses affective against sharp pain
o ability to cause mental clouding, sedation, euphoria, and anxiety
reduction can contribute to pain relief.
,Morphine actions: - 🧠 ANSWER ✔✔Analgesia, eurpohia, sedation, cough
suppression, biliary colic, emesis, elevated ICP, Miosis, Neurotoxicity,
Hormonal changes w prolonged use.
Adverse affects of Morphine - 🧠 ANSWER ✔✔Resp Depression
Tolerance to resp depression-long term use
When to NOT give Morphine: - 🧠 ANSWER ✔✔elderly/young (monitor)
Hx of Resp disease (COPD/Asthma)
Concurrent with CNS depressant
RR less than 12
*REVERSE WITH NARCAN*
Morphine depression varies by route: - 🧠 ANSWER ✔✔IV 7 min
IM 30 min
SQ 90 min
Spinal 4-5 hours
,Morphine S/E: Constipation tx - 🧠 ANSWER ✔✔Activation of mu receptors
of the gut, suppress propulsive intestinal contractions, intensify
nonpropulsive contractions, increase the tone of the anal sphincter,
inhibit secretion of fluid into the intestinal lumen
AEfecal impaction, bowel perf, rectal tearing, hemorrhoids
Prophylactic drugs for constipation - 🧠 ANSWER ✔✔stimulant lax- senna
polyethylene glycol (osmotic lax)
lactulose/sodium phosphate
methylnaltrexone (Relistor) aka: rescue therapy
Morphine Side effect: Orthostatic hypotension - 🧠 ANSWER ✔✔o R/t the
blunting of the baroreceptor relex and dilating peripheral arterioles and
veins. Causes the release of histamine
Morphine: urinary retention-- 3 mechanisms - 🧠 ANSWER ✔✔Increases
tone in the bladder sphincter
Increases tone in the detrusor muscle thereby elevating pressure within
the bladder causing a sense of urinary urgency
Interfere w voiding by suppressing awareness of bladder stimuli
COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED
, Tx of urinary retention with morphine - 🧠 ANSWER ✔✔encourage urination
q 4 hours
Hesitancy and retention esp likely in pt w BPH and drugs with
anticholinergic properties (tricyclic antidepressants, antihistamines) can
exacerbate the
prob
Morphine also used as - 🧠 ANSWER ✔✔Cough suppression
o Act at opioid receptors in the medulla
Morphine: side effect: Biliary colic - 🧠 ANSWER ✔✔Biliary Colic
o Induce spasm of the common bile duct, causing pressure w/in the biliary
tract to rise dramatically
Symptoms epigastric distress to biliary colic
Certain opioids cause less smooth muscle spam r/t morhpine admin? - 🧠
ANSWER ✔✔Demerol
Morphine side effect: emesis - 🧠 ANSWER ✔✔Emesis
o Caused by direct stimulation of the chemoreceptor trigger zone of the
medulla
