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Molecular structures clockwise from top: based on X-ray structures that were respectively determined by
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F U N D A M
d
E N T A L S O F
Biochemistry
LIFEAT d
THE MOLECULAR
d
LEVEL d
Voet Voet Pratt
F O U R T H E D I T I O N
Akif Uzman Jerry Johnson Joseph Eichberg William Widger
d d d d
Donald Voet Judith G. Voet CharlotteW.Pratt
d d d d d d
,This page is intentionally left blank
d d d d d
,STUDENT COMPANIONTO ACCOMPANY d d d
FUNDAMENTALS OF d
BIOCHEMISTRY
LIFE AT THE MOLECULAR LEVEL
d d d d
FourthEdition d
AkifUzman
d
UniversityofHouston d d
JerryJohnsond
UniversityofHouston d d
JosephEichberg d
UniversityofHouston d d
William Widger d
UniversityofHouston d d
DonaldVoet d
UniversityofPennsylvania d d
Judith G. Voet d d
SwarthmoreCollege d
Charlotte W. Pratt d d
Seattle,Washington d
JOHN WILEY & SONS, INC
d d d d
, Cover Designer Madelyn Lesure d d d
CoverIllustrationNormChristiansen
d d d d
Cover Photos
d d
(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy d d d d d d d
Molecular structures clockwise from top: based on X-ray structures that were respectively determined by
d d d d d d d d d d d d d
Richard Dickerson and Horace Drew, Caltech; Gerard Bunick, University of Tennessee; Thomas Steitz, Yale
d d d d d d d d d d d d d d
University; Alfonso Mondragón, Northwestern University; Venki Ramakrishnan, MRC Laboratory of
d d d d d d d d d d
Molecular Biology, Cambridge, U.K.; Andrew Leslie and John Walker, MRC Laboratoryof Molecular
d d d d d d d d d d d d d
Biology, Cambridge, U.K.
d d d
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and understanding for more
d d d d d d d d d d d d d d d d d d
than 200 years, helping people around the world meet their needs and fulfill their aspirations. Our company is
d d d d d d d d d d d d d d d d d d
built on a foundation of principles that include responsibility to the communities we serve andwhere we live and
d d d d d d d d d d d d d d d d d d d
work. In 2008, we launched a Corporate Citizenship Initiative, a global effort to address the environmental,
d d d d d d d d d d d d d d d d
social, economic, and ethical challenges we face in our business. Among the issues we are addressing are carbon
d d d d d d d d d d d d d d d d d d
impact, paper specifications and procurement, ethical conduct within our business and among our vendors, and
d d d d d d d d d d d d d d d
community and charitable support. For more information, please visit our website:
d d d d d d d d d d d
www.wiley.com/go/citizenship.
d
Copyright © 2012 d d John Wiley & Sons, Inc. d d d d
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in
d d d d d d d d d d d d d d d d d d
any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except as
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permitted under Sections 107 or 108 of the 1976 United States Copyright Act, without either the prior written
d d d d d d d d d d d d d d d d d d
permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright
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Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, website www.copyright.com. Requests to
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the Publisher for permission should be addressed to thePermissions Department, John Wiley & Sons, Inc. 111
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River Street, Hoboken, NJ 07030-5774, (201) 748-6011, fax (201) 748-6008, website
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http://www.wiley.com/go/permissions.
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To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
d d d d d d d d d d d
StudentCompanion (paperback) d d ISBN-13 978-1-1182-1827-3 d
Printed in the United States of America10 d d d d d d d
d 987 654 321
d d d d d d d d
