a/e of cyclophosphamide Correct Answer -myelosuppression
-alopecia
-hemorrhagic cystitis
A/E of cyclosporine Correct Answer -gingival hyperplasia
-mild to moderate HTN
-nephrotoxicity
a/e of epoetin alfa Correct Answer -HTN
-seizures may occur within 90 days of administration
An ANC above 100,000 can result in what? Correct Answer
respiratory failure
intracranial hemorrhage or infarction
retinal hemorrhage
MI
angiogenesis Correct Answer solid tumors create a new
capillary network to "feed" themselves; formation of new blood
vessels
BBW for doxorubicin Correct Answer -SIGNIFICANT
CARDIOTOXICITY, heart failure may occur months to 6
months after therapy
-severe myelosupression may occur- major dose limiting
toxicity, nadir 7 days
BBW for methotrexate Correct Answer -combination with
NSAIDs may cause severe or fatal myelosuppression
, -hepatotoxicity
-pulmonary toxicity
-dermatologic reactions
-ulcerative stomatitis and diarrhea
BBW for tamoxifen Correct Answer -increase risk for
endometrial CA
-slightly increase risk of thromboembolic disease (same as oral
contraceptives)
BBW of epoetin alfa Correct Answer -risk for cardiovascular
and thromboembolic events increased (TIA, MI, strokes have
occure with renal failure patients)
-increased rate of DVT formation
-lowest possible dose recommended for CA patients b/c the drug
may promote tumor progression in some patients
client teaching for chemo patients Correct Answer -avoid
antipyretics
-increase fluid intake to 2-3 L/day
-avoid crowded indoor areas
-cook food thoroughly
-avoid people with know infections and young children
common s/e of filgrastim Correct Answer thrombocytopenia
neutropenic fever
N/V (50%)
hyperuricemia
elevated liver enzymes
epistaxis (bloody nose)