1
NBME Practice Tests 2025 Actual exam (Testing Real
Exam Questions)and verified Answers ( 100%
accurate) GET IT RIGHT!!
What antiretroviral prevents entry into a CD4+ t-cell - (ANSWER)Enfuvirtide
Severe pain after meals (better when she doesn't eat), unintentional weight loss,
hx of atherosclerosis + abdominal bruit and absent pedal pulses. What artery
could be atherosclerotic? - (ANSWER)Superior Mesenteric
What is the inheritance pattern of Fragile X? How does transmission change if the
mother has fragile X vs. the father? - (ANSWER)It is X linked dominant (like
hypophosphatemic rickets and Alports)
Mothers w/ disease: give it to 50% of daughters and sons
Fathers w/ disease: give it to all daughters and no sons
What medication could be used for watery nasal decongestion during an allergy
attack? - (ANSWER)Alpha-adrenergic agonist (phenylephrine alpha 1 > alpha 2) in
Sudafed and most OTC decongestants
Newborn baby with hypothyroidism (no thyroid) has no symptoms. What can the
mom transfer to the baby allowing for normal development? -
(ANSWER)Thyroxine (T4) is transferred in late gestation through the placenta
preventing the initial symptoms of congenital hypothyroidism
, 2
How does enterococcus faecalis develop resistance from vancomycin? -
(ANSWER)Substitution of d-lactate for d-alanine in peptidoglycan wall
2 days following an acute MI, a pt becomes short of breath and diaphoretic, high
HR and pressure. What murmur would be heard? - (ANSWER)4/6 holosystolic
murmur heard best over the lower left sternal border and the cardiac apex
- from posteromedial papillary muscle rupture (has single blood supply from
posterior descending artery) -> severe mitral regurgitation occurs 2-7 days after
an MI
18 month old who has not eaten in 24 hrs has high pulse, increase respirations,
hepatomegaly. His glucose, ketones, and carnitine are decreased in serum, and
urine ketones are decreased, and dicarboxylic acids are present. He is given
medium chain triglycerides for 6 months which helps. What is deficient? -
(ANSWER)Very long-chain acyl-Coa dehydrogenase deficiency
- hypoketonic hypoglycemia
- fat deposits in liver = hepatomegaly
- cardiorespiratory distress
3 yo with constant fractures of bones, and blue sclera and normal teeth. What
biochemical process is altered? - (ANSWER)Procollagen synthesis
- Osteogenesis imperfecta
, 3
- AD
- glycosylation of residues and then forms disulfide/hydrogen bonds -> triple helix
(will not occur in this disease)
- no normal type ONE collagen (bone)
-treat with bisphosphanates to prevents fractures
Cross sections area of an aneurysm is 2cm^2, and the velocity of blood flow is
20cm/sec. What is the flow rate (L/min) through the aneurysm? - (ANSWER)Flow
rate (Q) = Flow velocity X cross sectional area
- 2X20 = 40cm^3/sec
- 40X60s = 24000 mm/sec (1cm^3 = 1 mm)
- 2.4L/min
severe bleed from gunshot wound to abdomen -> 3L blood in peritoneum. Cells in
liver/kidney = centrilobular pallor and swelling. Why is this occurring? -
(ANSWER)decreased function of Na+/K+ ATPase
- reversible injury from blood loss
What does fish oil do? - (ANSWER)fish oil/omega 3 fatty acids antagonize VLDL-
cholesterol secretion
- increase LDL/HDL slightly
, 4
- decrease FFA delivery to liver
60 yo man with no hx of bleeding problems has elevated PTT what molecule in
the kinin cascade can be deficient? - (ANSWER)Kallikrein -> leads to a build up of
high molecular weight kininogen that activates the intrinsic pathway -> elevated
PTT
23 yo with sjogren and burning pain in feet is relieved with capsaicin. what
neurotransmitter is causing pain? - (ANSWER)Substance P
18 yo w/ ALL on chemo and low neutrophil count has lung infiltrate with PAS stain
of budding fungus. How do you treat him? - (ANSWER)amphotericin B
- most likely cryptoccocus neoformans
12 yo with 6 months of difficulty walking and leg pain. Atrophy of LE and hammer
toes with a high stepping gait. What will a bc show? - (ANSWER)Abnormal Myelin
sheath
- AD
- pes cavus, hammer toe
- CMT1A/PMP22
mass in ovaries (CA 125 positive cancer) needs to be removed. What structure
passing inferior to ovary is at risk of injury? - (ANSWER)ureter
NBME Practice Tests 2025 Actual exam (Testing Real
Exam Questions)and verified Answers ( 100%
accurate) GET IT RIGHT!!
What antiretroviral prevents entry into a CD4+ t-cell - (ANSWER)Enfuvirtide
Severe pain after meals (better when she doesn't eat), unintentional weight loss,
hx of atherosclerosis + abdominal bruit and absent pedal pulses. What artery
could be atherosclerotic? - (ANSWER)Superior Mesenteric
What is the inheritance pattern of Fragile X? How does transmission change if the
mother has fragile X vs. the father? - (ANSWER)It is X linked dominant (like
hypophosphatemic rickets and Alports)
Mothers w/ disease: give it to 50% of daughters and sons
Fathers w/ disease: give it to all daughters and no sons
What medication could be used for watery nasal decongestion during an allergy
attack? - (ANSWER)Alpha-adrenergic agonist (phenylephrine alpha 1 > alpha 2) in
Sudafed and most OTC decongestants
Newborn baby with hypothyroidism (no thyroid) has no symptoms. What can the
mom transfer to the baby allowing for normal development? -
(ANSWER)Thyroxine (T4) is transferred in late gestation through the placenta
preventing the initial symptoms of congenital hypothyroidism
, 2
How does enterococcus faecalis develop resistance from vancomycin? -
(ANSWER)Substitution of d-lactate for d-alanine in peptidoglycan wall
2 days following an acute MI, a pt becomes short of breath and diaphoretic, high
HR and pressure. What murmur would be heard? - (ANSWER)4/6 holosystolic
murmur heard best over the lower left sternal border and the cardiac apex
- from posteromedial papillary muscle rupture (has single blood supply from
posterior descending artery) -> severe mitral regurgitation occurs 2-7 days after
an MI
18 month old who has not eaten in 24 hrs has high pulse, increase respirations,
hepatomegaly. His glucose, ketones, and carnitine are decreased in serum, and
urine ketones are decreased, and dicarboxylic acids are present. He is given
medium chain triglycerides for 6 months which helps. What is deficient? -
(ANSWER)Very long-chain acyl-Coa dehydrogenase deficiency
- hypoketonic hypoglycemia
- fat deposits in liver = hepatomegaly
- cardiorespiratory distress
3 yo with constant fractures of bones, and blue sclera and normal teeth. What
biochemical process is altered? - (ANSWER)Procollagen synthesis
- Osteogenesis imperfecta
, 3
- AD
- glycosylation of residues and then forms disulfide/hydrogen bonds -> triple helix
(will not occur in this disease)
- no normal type ONE collagen (bone)
-treat with bisphosphanates to prevents fractures
Cross sections area of an aneurysm is 2cm^2, and the velocity of blood flow is
20cm/sec. What is the flow rate (L/min) through the aneurysm? - (ANSWER)Flow
rate (Q) = Flow velocity X cross sectional area
- 2X20 = 40cm^3/sec
- 40X60s = 24000 mm/sec (1cm^3 = 1 mm)
- 2.4L/min
severe bleed from gunshot wound to abdomen -> 3L blood in peritoneum. Cells in
liver/kidney = centrilobular pallor and swelling. Why is this occurring? -
(ANSWER)decreased function of Na+/K+ ATPase
- reversible injury from blood loss
What does fish oil do? - (ANSWER)fish oil/omega 3 fatty acids antagonize VLDL-
cholesterol secretion
- increase LDL/HDL slightly
, 4
- decrease FFA delivery to liver
60 yo man with no hx of bleeding problems has elevated PTT what molecule in
the kinin cascade can be deficient? - (ANSWER)Kallikrein -> leads to a build up of
high molecular weight kininogen that activates the intrinsic pathway -> elevated
PTT
23 yo with sjogren and burning pain in feet is relieved with capsaicin. what
neurotransmitter is causing pain? - (ANSWER)Substance P
18 yo w/ ALL on chemo and low neutrophil count has lung infiltrate with PAS stain
of budding fungus. How do you treat him? - (ANSWER)amphotericin B
- most likely cryptoccocus neoformans
12 yo with 6 months of difficulty walking and leg pain. Atrophy of LE and hammer
toes with a high stepping gait. What will a bc show? - (ANSWER)Abnormal Myelin
sheath
- AD
- pes cavus, hammer toe
- CMT1A/PMP22
mass in ovaries (CA 125 positive cancer) needs to be removed. What structure
passing inferior to ovary is at risk of injury? - (ANSWER)ureter
