MMSC491 Exam 3 QUESTIONS WITH |\ |\ |\ |\ |\
ANSWERS
What is the most appropriate gene therapy for treating cancer?
|\ |\ |\ |\ |\ |\ |\ |\ |\
a. Repair of mutant gene
|\ |\ |\ |\
b. Modifying disease cells
|\ |\ |\
c. Killing disease cells
|\ |\ |\
d. Gene augmentation - CORRECT ANSWERS ✔✔Killing disease
|\ |\ |\ |\ |\ |\ |\ |\
cells
How do cancer cells avoid chromosome destabilization due to
|\ |\ |\ |\ |\ |\ |\ |\ |\
their rapidly shortening telomeres? - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\
✔✔They express telomerase |\ |\
In cancer cells, hypomethylation of DNA results in... - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔None of the above |\ |\ |\ |\
Which of the following databases contains descriptions of
|\ |\ |\ |\ |\ |\ |\ |\
genomic, transcriptomic, and epigenetic changes in different
|\ |\ |\ |\ |\ |\ |\
types of tumors? - CORRECT ANSWERS ✔✔ICGC
|\ |\ |\ |\ |\ |\
Which of the following discoveries in cancer research is a direct
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
result of the advent of next-generation sequencing? - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Extraordinary mutational diversity in tumors
|\ |\ |\ |\ |\
, Which of the following is not a method of oncogene activation? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔RAS/RAF pathway activation
|\ |\ |\ |\
Which of the following is true about miRNA in cancer cells? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔miRNAs have regulatory rules in
|\ |\ |\ |\ |\ |\ |\
apoptosis, cell-cycle control and DNA damage responses
|\ |\ |\ |\ |\ |\
Which of the following can result from telomere instability in
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
cancer cells? - CORRECT ANSWERS ✔✔The cell does not
|\ |\ |\ |\ |\ |\ |\ |\ |\
recognize the DNA as a chromosome and fuses it to another
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
chromosome
Which of the following regarding genome wide gene expression
|\ |\ |\ |\ |\ |\ |\ |\ |\
screens is false? - CORRECT ANSWERS ✔✔The hybridization
|\ |\ |\ |\ |\ |\ |\ |\
probes bind to proteins within the cell
|\ |\ |\ |\ |\ |\
Which of the following is defined as large numbers of
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
chromosomal rearrangements are generated in what appear to |\ |\ |\ |\ |\ |\ |\ |\
be single catastrophic events? - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\
✔✔Chromothripsis
During a tumor removal surgery, the tumor is found to be a small
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
mass of cells that has not affected any neighboring tissues.
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
Several months later the patient is re-evaluated and is not
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
showing any signs of recurrence. What kind of tumor did the
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
patient most have? - CORRECT ANSWERS ✔✔Benign tumor
|\ |\ |\ |\ |\ |\ |\
Which of the following is NOT a characteristic of cancer cells? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Increased genome stability
|\ |\ |\ |\
ANSWERS
What is the most appropriate gene therapy for treating cancer?
|\ |\ |\ |\ |\ |\ |\ |\ |\
a. Repair of mutant gene
|\ |\ |\ |\
b. Modifying disease cells
|\ |\ |\
c. Killing disease cells
|\ |\ |\
d. Gene augmentation - CORRECT ANSWERS ✔✔Killing disease
|\ |\ |\ |\ |\ |\ |\ |\
cells
How do cancer cells avoid chromosome destabilization due to
|\ |\ |\ |\ |\ |\ |\ |\ |\
their rapidly shortening telomeres? - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\
✔✔They express telomerase |\ |\
In cancer cells, hypomethylation of DNA results in... - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔None of the above |\ |\ |\ |\
Which of the following databases contains descriptions of
|\ |\ |\ |\ |\ |\ |\ |\
genomic, transcriptomic, and epigenetic changes in different
|\ |\ |\ |\ |\ |\ |\
types of tumors? - CORRECT ANSWERS ✔✔ICGC
|\ |\ |\ |\ |\ |\
Which of the following discoveries in cancer research is a direct
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
result of the advent of next-generation sequencing? - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Extraordinary mutational diversity in tumors
|\ |\ |\ |\ |\
, Which of the following is not a method of oncogene activation? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔RAS/RAF pathway activation
|\ |\ |\ |\
Which of the following is true about miRNA in cancer cells? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔miRNAs have regulatory rules in
|\ |\ |\ |\ |\ |\ |\
apoptosis, cell-cycle control and DNA damage responses
|\ |\ |\ |\ |\ |\
Which of the following can result from telomere instability in
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
cancer cells? - CORRECT ANSWERS ✔✔The cell does not
|\ |\ |\ |\ |\ |\ |\ |\ |\
recognize the DNA as a chromosome and fuses it to another
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
chromosome
Which of the following regarding genome wide gene expression
|\ |\ |\ |\ |\ |\ |\ |\ |\
screens is false? - CORRECT ANSWERS ✔✔The hybridization
|\ |\ |\ |\ |\ |\ |\ |\
probes bind to proteins within the cell
|\ |\ |\ |\ |\ |\
Which of the following is defined as large numbers of
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
chromosomal rearrangements are generated in what appear to |\ |\ |\ |\ |\ |\ |\ |\
be single catastrophic events? - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\
✔✔Chromothripsis
During a tumor removal surgery, the tumor is found to be a small
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
mass of cells that has not affected any neighboring tissues.
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
Several months later the patient is re-evaluated and is not
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
showing any signs of recurrence. What kind of tumor did the
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
patient most have? - CORRECT ANSWERS ✔✔Benign tumor
|\ |\ |\ |\ |\ |\ |\
Which of the following is NOT a characteristic of cancer cells? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Increased genome stability
|\ |\ |\ |\
