MMSC 433 Exam 3 Questions with precise detailed ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
solutions
a "dry tap" bone marrow aspiration may be seen with what chronic myeloid proliferative
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disease?
A: essential thrombocythemia
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B: polycythemia vera
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C: primary myelofibrosis
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D: Chronic myeloid leukemia - correct answer✔✔Primary myelofibrosis
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what clinical feature is more often associated with essential thrombocythemia than with the
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other chronic myeloproliferative disorders?
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A: bleeding and thrombosis
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B: infections
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C: splenomegaly
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D: fatigue - correct answer✔✔bleeding and thromboses
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what is the most common chromosomal abnormality in polycythemia vera (PV)?
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A: BCR-ABL ||//\\||
B: PML-RARA ||//\\||
C: TET-2 ||//\\||
D: JAK2V617F - correct answer✔✔JAK2V617F
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,which of the following is an expected finding in polycythemia vera?
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A: normal white cell count
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B: anemia ||//\\||
C: increased RBC mass
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D: low leukocyte alkaline phosphatase - correct answer✔✔increased RBC mass
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a patient has a normal white cell count, a moderately high platelet count, and mild anemia.
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
The differential shows immature granulocytes, nucleated red cells, and teardrop-shaped red
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cells. Which of the following is most likely?
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A: chronic myelogenous leukoemia
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B: primary myelofibrosis
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C: polycythemia vera
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D: essential thrombocythemia - correct answer✔✔primary myelofibrosis
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a patient has a platelet count of 1200*10⁹/L. Many platelets are giant and have abnormal
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shapes. A mild anemia is present. The bone marrow has increased megakaryocytes in
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clusters; iron stores are present. Which of the following is most likely? ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: chronic myelogenous leukemia
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B: polycythemia vera
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C: thrombosis secondary to blood loss
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D: essential thrombocythemia - correct answer✔✔essential thrombocythemia
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which one of the following chromosome abnormalities is associated with CML?
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, A: t(8;14)
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B: trisomy 18
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C: t(15;17)
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D: t(9;22) - correct answer✔✔t(9;22)
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all of the following are minor criteria for overt PMF, except:
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A: WBC count < 10*10⁹/L
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B: palpable splenomegaly
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C: leukoerythroblastosis
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D: leukocytosis ≥ 11*10⁹/L - correct answer✔✔WBC count < 10*10⁹/L
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what is the treatment for Polycythemia Vera (PV)?
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A: therapeutic phlebotomy
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B: ruxolitinib (inhibitor of JAK2)
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C: hydroxyurea
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D: all answers are correct - correct answer✔✔all answers are correct
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hematopoietic stem cell transplantation is accepted as a cure for MDS ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: true
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B: false - correct answer✔✔true
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solutions
a "dry tap" bone marrow aspiration may be seen with what chronic myeloid proliferative
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
disease?
A: essential thrombocythemia
||//\\|| ||//\\||
B: polycythemia vera
||//\\|| ||//\\||
C: primary myelofibrosis
||//\\|| ||//\\||
D: Chronic myeloid leukemia - correct answer✔✔Primary myelofibrosis
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
what clinical feature is more often associated with essential thrombocythemia than with the
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
other chronic myeloproliferative disorders?
||//\\|| ||//\\|| ||//\\||
A: bleeding and thrombosis
||//\\|| ||//\\|| ||//\\||
B: infections
||//\\||
C: splenomegaly
||//\\||
D: fatigue - correct answer✔✔bleeding and thromboses
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
what is the most common chromosomal abnormality in polycythemia vera (PV)?
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: BCR-ABL ||//\\||
B: PML-RARA ||//\\||
C: TET-2 ||//\\||
D: JAK2V617F - correct answer✔✔JAK2V617F
||//\\|| ||//\\|| ||//\\|| ||//\\||
,which of the following is an expected finding in polycythemia vera?
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: normal white cell count
||//\\|| ||//\\|| ||//\\|| ||//\\||
B: anemia ||//\\||
C: increased RBC mass
||//\\|| ||//\\|| ||//\\||
D: low leukocyte alkaline phosphatase - correct answer✔✔increased RBC mass
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
a patient has a normal white cell count, a moderately high platelet count, and mild anemia.
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
The differential shows immature granulocytes, nucleated red cells, and teardrop-shaped red
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
cells. Which of the following is most likely?
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: chronic myelogenous leukoemia
||//\\|| ||//\\|| ||//\\||
B: primary myelofibrosis
||//\\|| ||//\\||
C: polycythemia vera
||//\\|| ||//\\||
D: essential thrombocythemia - correct answer✔✔primary myelofibrosis
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
a patient has a platelet count of 1200*10⁹/L. Many platelets are giant and have abnormal
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
shapes. A mild anemia is present. The bone marrow has increased megakaryocytes in
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
clusters; iron stores are present. Which of the following is most likely? ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: chronic myelogenous leukemia
||//\\|| ||//\\|| ||//\\||
B: polycythemia vera
||//\\|| ||//\\||
C: thrombosis secondary to blood loss
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
D: essential thrombocythemia - correct answer✔✔essential thrombocythemia
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
which one of the following chromosome abnormalities is associated with CML?
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
, A: t(8;14)
||//\\||
B: trisomy 18
||//\\|| ||//\\||
C: t(15;17)
||//\\||
D: t(9;22) - correct answer✔✔t(9;22)
||//\\|| ||//\\|| ||//\\|| ||//\\||
all of the following are minor criteria for overt PMF, except:
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: WBC count < 10*10⁹/L
||//\\|| ||//\\|| ||//\\|| ||//\\||
B: palpable splenomegaly
||//\\|| ||//\\||
C: leukoerythroblastosis
||//\\||
D: leukocytosis ≥ 11*10⁹/L - correct answer✔✔WBC count < 10*10⁹/L
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
what is the treatment for Polycythemia Vera (PV)?
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: therapeutic phlebotomy
||//\\|| ||//\\||
B: ruxolitinib (inhibitor of JAK2)
||//\\|| ||//\\|| ||//\\|| ||//\\||
C: hydroxyurea
||//\\||
D: all answers are correct - correct answer✔✔all answers are correct
||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
hematopoietic stem cell transplantation is accepted as a cure for MDS ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\|| ||//\\||
A: true
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B: false - correct answer✔✔true
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