Question 1
pts
A 65-year-old patient presents with increased urination. The patient states there is a strong family
history of type 2 diabetes and expresses concern about “getting diabetes.” The physical assessment
indicates vital signs are within normal limits and body mass index (BMI) is 29%. Along with obtaining
laboratory tests, what intervention should the healthcare provider perform at this initial visit?
a- Identify family members with a history of diabetes.
b- Share with the patient that eventual insulin therapy is likely to be needed.
c- Talk to the patient about adjusting calorie intake to promote weight loss.
d- Suggest that starting on empagliflozin therapy immediately would be appropriate.
Rationale: For those patients who are at their ideal body weight, the lifestyle interventions would be
more directed toward regulation of caloric intake to maintain weight and glucose control, whereas
those patients above their ideal body weight would have interventions directed to achieving weight loss.
Weight loss leads to improved glucose tolerance by enhancing the sensitivity of peripheral glucose
receptors in adipose and muscle cells. This patient’s BMI indicates overweight status bordering on
obesity, so weight loss is appropriate. Additional information and diagnostic procedures will be needed
to confirmed that the patient has a family history of type 2 diabetes is actually experiencing diabetes.
The diagnosis of type 2 diabetes should be made before medication therapy of any type is initiated.
Question 2
pts
Which statement(s) presents a relevant characteristic of the pathogenesis of type 2 diabetes and so is a
consideration in its treatment? Select all that apply.
a- Insulin secretion is impaired.
b- Muscle cells become insulin resistant.
c- The liver glucose production is increased.
d- To compensate, circulating insulin concentrations decrease.
e- Faulty beta cells are the primary cause of this form of diabetes.
Rationale: The pathogenesis of type 2 diabetes involves insulin resistance, impaired insulin secretion,
and elevated glucose production by the liver. With insulin resistance, circulating insulin concentrations
, increase as compensation. Researchers have hypothesized that in type 2 diabetes, the ability of insulin
to inhibit hepatic glucose production and to stimulate its uptake and use by adipose and muscle cells is
diminished. In lean patients with type 2 diabetes, the primary defect appears to occur in the beta cells.
In overweight patients, who represent most patients with type 2 diabetes, the most likely primary defect
is impairment of the target cells.
Question 3
pts
The patient who presented for an annual well physical 3 months ago had an elevated A1C. Today’s
HBA1C result is 7.5% (0.75), having only decreased minimally with diet and lifestyle changes alone. What
action will the healthcare provider discuss with the patient in response to this information?
Needing to prescribe acarbose
Initiating monotherapy using metformin
Starting a fixed-dose combination product
Considering short-term use of insulin on a sliding scale
Rationale: If diet and lifestyle interventions fail to achieve desirable glycemic control, the healthcare
provider should consider pharmacologic approaches. Metformin, a biguanide, can be used in
conjunction with diet as first-line monotherapy. Due to the limited ability of alpha-glucosidase Inhibitors
like acarbose to lower A1C and their side effect profile, they are not commonly used as monotherapy
but as adjuncts to existing therapy. Fixed-dose combinations are generally tried after a patient has failed
to reach reduction of hyperglycemic goals. Insulin is the only drug therapy of choice for patients with
type 1 diabetes and for those patients with type 2 diabetes who cannot control the condition with diet
and exercise alone or in whom combination therapy has failed. This information tends to support
monotherapy using metformin as the best initial option for this patient.
Question 4
pts
The healthcare provider will recognize canagliflozin is contraindicated for the treatment of which patient
diagnosed with type 2 diabetes?
50-year-old on hemodialysis
70-year-old on insulin therapy
45-year-old with a history of hypokalemia