Med Chem Exam 2 Test Bank
Questions with Guaranteed Pass
Solutions 2025 Set.
What is meant by a lead compound in medicinal chemistry?
a) A drug containing the element lead.
b) A leading drug in a particular area of medicine.
c) A compound that acts as the starting point for drug design and development.
d) A drug which is normally the first to be prescribed for a particular ailment. - Answer c
A lead compound is a compound that acts as the starting point for drug design and
development. It may have disadvantages such as low activity or the presence of side effects, but
it acts as a starting point for the development of a better agent.
Which of the following needs to be established before the search for a lead compound takes
place?
a) the pharmacophore
b) Structure-activity relationships
c) a bioassay
d) patents - Answer c
The lead compound has to have some sort of desirable biological activity, and so a bioassay to
,What is the term used for the automated in vitro testing of large numbers of compounds using
genetically modified cells?
a) robotic testing
b) high throughput screening
c) multiscreening
d) nanotechnology - Answer b
As well as being automated and capable of handling large numbers of compounds, high
throughput screening (HTS) can be carried out on small scale, allowing results to be obtained
quickly and efficiently.
Which of the following statements is false with respect to nmr screening to detect drug-target
interactions?
a) The procedure relies on small molecules (drugs) having shorter relaxation times than large
molecules (targets).
b) The procedure can be used on mixtures of compounds.
c) The method can detect weak binding.
d) The method can identify small molecules binding to different regions of the same binding
site. - Answer a
The procedure relies on small molecules (drugs) having longer relaxation times than large
molecules (targets). When a small drug binds to a macromolecular target, it essentially becomes
part of that target and the signals for that compound will have shorter relaxation times. If there
is a time delay in measuring the nmr spectrum, the signals for molecules that bind to the
, a) nuclear magnetic resonance
b) electron spin resonance
c) surface plasmon resonance
d) scintillation proximate assay - Answer c
Nuclear magnetic resonance and electron spin resonance are both forms of spectroscopy.
BIAcore makes use of surface plasmon resonance, which involves the interaction of a reflected
wave of plane polarised light with free oscillating electrons called plasmons in a metal film.
Scintillation proximate assay involves the immobilisation of a target molecule on beads coated
with a scintillant. A ligand labelled with 125I binds to the target and the radioisotope interacts
with the scintillant to emit light.
There are several sources and methods of discovering new compounds. Which of the following
is most likely to lead to the discovery of a complex structure quite unlike any other previously
discovered?
a) combinatorial chemistry
b) database mining
c) screening plant extracts
d) me too drugs - Answer c
There are no preconceived ideas when screening plant extracts for active lead compounds.
Some natural products are quite bizarre in structure!
Combinatorial chemistry involves the synthesis of a large number of compounds using a
standard synthetic route, and so the types of structures that will be synthesised are predictable
Questions with Guaranteed Pass
Solutions 2025 Set.
What is meant by a lead compound in medicinal chemistry?
a) A drug containing the element lead.
b) A leading drug in a particular area of medicine.
c) A compound that acts as the starting point for drug design and development.
d) A drug which is normally the first to be prescribed for a particular ailment. - Answer c
A lead compound is a compound that acts as the starting point for drug design and
development. It may have disadvantages such as low activity or the presence of side effects, but
it acts as a starting point for the development of a better agent.
Which of the following needs to be established before the search for a lead compound takes
place?
a) the pharmacophore
b) Structure-activity relationships
c) a bioassay
d) patents - Answer c
The lead compound has to have some sort of desirable biological activity, and so a bioassay to
,What is the term used for the automated in vitro testing of large numbers of compounds using
genetically modified cells?
a) robotic testing
b) high throughput screening
c) multiscreening
d) nanotechnology - Answer b
As well as being automated and capable of handling large numbers of compounds, high
throughput screening (HTS) can be carried out on small scale, allowing results to be obtained
quickly and efficiently.
Which of the following statements is false with respect to nmr screening to detect drug-target
interactions?
a) The procedure relies on small molecules (drugs) having shorter relaxation times than large
molecules (targets).
b) The procedure can be used on mixtures of compounds.
c) The method can detect weak binding.
d) The method can identify small molecules binding to different regions of the same binding
site. - Answer a
The procedure relies on small molecules (drugs) having longer relaxation times than large
molecules (targets). When a small drug binds to a macromolecular target, it essentially becomes
part of that target and the signals for that compound will have shorter relaxation times. If there
is a time delay in measuring the nmr spectrum, the signals for molecules that bind to the
, a) nuclear magnetic resonance
b) electron spin resonance
c) surface plasmon resonance
d) scintillation proximate assay - Answer c
Nuclear magnetic resonance and electron spin resonance are both forms of spectroscopy.
BIAcore makes use of surface plasmon resonance, which involves the interaction of a reflected
wave of plane polarised light with free oscillating electrons called plasmons in a metal film.
Scintillation proximate assay involves the immobilisation of a target molecule on beads coated
with a scintillant. A ligand labelled with 125I binds to the target and the radioisotope interacts
with the scintillant to emit light.
There are several sources and methods of discovering new compounds. Which of the following
is most likely to lead to the discovery of a complex structure quite unlike any other previously
discovered?
a) combinatorial chemistry
b) database mining
c) screening plant extracts
d) me too drugs - Answer c
There are no preconceived ideas when screening plant extracts for active lead compounds.
Some natural products are quite bizarre in structure!
Combinatorial chemistry involves the synthesis of a large number of compounds using a
standard synthetic route, and so the types of structures that will be synthesised are predictable
