Page 1 of 742
NBME CBSE ACTUAL TEST ALL 2600 QUESTIONS AND
ANSWERS 2025/2026(Quiz bank with all the correct
answers)(usmle step 1)Medical examination
62 year old woman - osteoporosis - a bisphosphonate is prescribed. The expected beneficial effect of the
drug is due to which of the following? - Answer: Decreased Osteoclast Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among those who exercise regularly is
1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion about the effect of
exercise on the risk of hip fracture? - Answer: Statistically Significant Overall Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is 80/min
and blood pressure is 130/70. The most immediate treatment mechanism of action? - Answer: Increased
nitric oxide concentration
24 year old woman - spilled hot grease on her left leg while working at a fast-food restaurant. Exam of
leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was most likely
caused by increased activity of which? - Answer: a. Vascular Endothelial Growth Factor
VEGF - stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels - early wound repair
27 year old man- MVC - skull x-ray shows a linear, nondepressed basal skull fracture - increased serum
osm and decreased urin osm. Following desmopressin urine osm increases. Desmopressin's effect is due
to the activation of which of the following? - Answer: a. Adenylyl Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy - 4 day history of fever and cough. He attends day care center. Chest exam shows
intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The infectious agent
most likely has which of the following properties? - Answer: Mediation of Cell Entry via a fusion protein
,Page 2 of 742
A 17 year old girl in ED - 15 minutes after being stung by a bee. Mild light headedness but no difficulty
swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this patient? - Answer:
B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week of fatigue.
He recentaly had sex with one partner. Physical exam show cervical lymphadenopathy and pharyngeal
erythema with a creamy exudate. DX? - Answer: Infectious Mononucleosis
57 year old man - radiation therapy for squamous cell carcinoma of the lung. Despite therapy, tumor
increases in size and he dies 6 months later. The progressive tumor growth is due to a defect in cell cycle
arrest in which of the following phases of cell cycle? - Answer: G1
28 year old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 - imaging shows
bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered granulomas. DX?
- Answer: Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two gene
deletion. If the two gene is trans - what percentage of offspring will have a two gene deletion? - Answer:
50%
previously healthy 40 year brought to emergency department by her husband - 2 day history of fever,
lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower extremities - 3+
polychromasia and 3+ schistocytes and Low platelets Dx? - Answer: Thrombotic Thrombocytopenia
Purpura
16 year old boy - is admitted to the ER because of a knife wound to the left side of his chest. An X -ray of
the chest shows an air-fluid level in the left side of the chest, partial collapse of the left lung, and the
elevation of the stomach bubble. The mediastinum is midline. DX? - Answer: Hemopneumpothorax
under tension
49 year old woman - coronary artery disease - BP 140/90 - High Cholesterol, High LDL (190), High
triglycerides (350) - TX with atorvastatin and losartan. What are the effects on HDL and Triglycerides? -
Answer: HDL increased
Triglycerides Decreased
,Page 3 of 742
73 yeare old - diffuse weakness and tingling of her arms and legs. Sensation and vibration and position is
decreased in all extremities. What vitamin deficiency? - Answer: Vitamin B12 - (cyanocobalamin)
Tea and Toast - low B12 in diet
15 year old girl - 3 month history of acne - which is the underlying cause of the patients acne? - Answer:
Stimulation of Sebaceous Glands by androgens
b. ACNE = Propionibacterium ACNE
4 year old from Brazil - PE shows single 12x10cm lesion in the right side of jaw with diffuse regular
edges. Photomicrographs of an incisional biopsy (looks like Burkitts Lymphoma/ Starry night) - which of
the processes most likely to occur in the region indicated by the arrow? - Answer: Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion, puffy face).
51 year old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass on apex of tongue. It is
most appropriate to evaluate which lymph nodes first for evidence of metastasis? - Answer: Submental
15 year old boy - ER - 2 hour history of confusion and agitation - fever, headache, stiff neck, and
vomiting - since returned from summer camp - patient is hallucinating - lumbar puncture - shows cysts
and trophozoites- most likely pathogen? - Answer: a. Olfactory Nerve
Naegleria fowleri
17 year old - ED - 30 minutes after being found with a blank stare. Physical exam shows rigidity. During
exam he becomes hostile and assaults physician - Pt ingested which drug? - Answer: PCP
Placebo controlled clinical trial - 5000 pts with essential hypertension. 2500 patients receive new drug
and 2500 patients receive placebo. If alpha is set at 0.01 instead of 0.05, which of the following is most
likely result? - Answer: Significant findings can be reported with greater confidence
17 year old - gymnast - comes to hospital because of lack of menstrual period for 6 months. BMI 15
Which is the cause of the amenorrhea? - Answer: Hypogonadotropic Hypogonadism
A male stillborn is delivered at 32 weeks - Oligohydramnios - absence of a urethral opening. Which is
most likely finding? - Answer: Pulmonary Hypoplasia
, Page 4 of 742
A 6 day old - breast fed boy in ED - poor weight gain and irritability since delivery - Physical exam shows
jaundice and hepatomegaly. The concentration of which of the following metabolites is most likely
increased? - Answer: a. Galactose - 1 - phosphate
b. Congenital intolerance to breast milk
A 25-year-old man - comes to ED - severe muscle pain, diffuse, painful swelling of his neck, underarms,
and groin after camping in New Mexico Generalized scattered black maculae. Examination of the right
upper extremity shows erythematous, solid, tender mass. Mass is draining blood and necrotic material.
The most effective antibiotic for patient disorder will interfere with which of the following processes? -
Answer: a. Ribosomal Assembly
b. Yersenia Pestis
45 year old - progressive weakness - muscle fasciculations of the upper extremities and weakness of the
lower extremity - What additional findings? - Answer: Atrophy
b. ALS = Lou Gherig
A new severe respiratory illness - Why use a killed vaccine vs a live vaccine? - Answer: Avoids Concerns
of reversion to virulence
b. Killed vaccines - avoids reversion to virulence
c. live vaccines - can (but rarely do) cause the disease they're designed to prevent
A 33 year old - keratinizing squamous cell carcinoma of cervix. Which of the following describes
pathogenesis of this patient's disease? - Answer: Inactivation of Cellular P53
b. p53 protein = tumor suppressor (it activates apoptosis) - most human cancer
A 54 year old - 40 year history of T1DM - receiving hemodialysis for end stage renal disease while
awaiting a kidney transplant. Receives a drug that induces reticulocyte release from bone marrow and
stimulates a cytokine receptor that signals Jak/Stat pathway? - Answer: Erythropoietin
Jak Stat - erythropoietin
During a clinical study examining the effects of exercise. The average pulse is 175/min. Compared with
measurement before the session, which is most likely decreased? - Answer: Total Peripheral Resistance
NBME CBSE ACTUAL TEST ALL 2600 QUESTIONS AND
ANSWERS 2025/2026(Quiz bank with all the correct
answers)(usmle step 1)Medical examination
62 year old woman - osteoporosis - a bisphosphonate is prescribed. The expected beneficial effect of the
drug is due to which of the following? - Answer: Decreased Osteoclast Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among those who exercise regularly is
1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion about the effect of
exercise on the risk of hip fracture? - Answer: Statistically Significant Overall Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is 80/min
and blood pressure is 130/70. The most immediate treatment mechanism of action? - Answer: Increased
nitric oxide concentration
24 year old woman - spilled hot grease on her left leg while working at a fast-food restaurant. Exam of
leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was most likely
caused by increased activity of which? - Answer: a. Vascular Endothelial Growth Factor
VEGF - stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels - early wound repair
27 year old man- MVC - skull x-ray shows a linear, nondepressed basal skull fracture - increased serum
osm and decreased urin osm. Following desmopressin urine osm increases. Desmopressin's effect is due
to the activation of which of the following? - Answer: a. Adenylyl Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy - 4 day history of fever and cough. He attends day care center. Chest exam shows
intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The infectious agent
most likely has which of the following properties? - Answer: Mediation of Cell Entry via a fusion protein
,Page 2 of 742
A 17 year old girl in ED - 15 minutes after being stung by a bee. Mild light headedness but no difficulty
swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this patient? - Answer:
B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week of fatigue.
He recentaly had sex with one partner. Physical exam show cervical lymphadenopathy and pharyngeal
erythema with a creamy exudate. DX? - Answer: Infectious Mononucleosis
57 year old man - radiation therapy for squamous cell carcinoma of the lung. Despite therapy, tumor
increases in size and he dies 6 months later. The progressive tumor growth is due to a defect in cell cycle
arrest in which of the following phases of cell cycle? - Answer: G1
28 year old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 - imaging shows
bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered granulomas. DX?
- Answer: Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two gene
deletion. If the two gene is trans - what percentage of offspring will have a two gene deletion? - Answer:
50%
previously healthy 40 year brought to emergency department by her husband - 2 day history of fever,
lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower extremities - 3+
polychromasia and 3+ schistocytes and Low platelets Dx? - Answer: Thrombotic Thrombocytopenia
Purpura
16 year old boy - is admitted to the ER because of a knife wound to the left side of his chest. An X -ray of
the chest shows an air-fluid level in the left side of the chest, partial collapse of the left lung, and the
elevation of the stomach bubble. The mediastinum is midline. DX? - Answer: Hemopneumpothorax
under tension
49 year old woman - coronary artery disease - BP 140/90 - High Cholesterol, High LDL (190), High
triglycerides (350) - TX with atorvastatin and losartan. What are the effects on HDL and Triglycerides? -
Answer: HDL increased
Triglycerides Decreased
,Page 3 of 742
73 yeare old - diffuse weakness and tingling of her arms and legs. Sensation and vibration and position is
decreased in all extremities. What vitamin deficiency? - Answer: Vitamin B12 - (cyanocobalamin)
Tea and Toast - low B12 in diet
15 year old girl - 3 month history of acne - which is the underlying cause of the patients acne? - Answer:
Stimulation of Sebaceous Glands by androgens
b. ACNE = Propionibacterium ACNE
4 year old from Brazil - PE shows single 12x10cm lesion in the right side of jaw with diffuse regular
edges. Photomicrographs of an incisional biopsy (looks like Burkitts Lymphoma/ Starry night) - which of
the processes most likely to occur in the region indicated by the arrow? - Answer: Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion, puffy face).
51 year old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass on apex of tongue. It is
most appropriate to evaluate which lymph nodes first for evidence of metastasis? - Answer: Submental
15 year old boy - ER - 2 hour history of confusion and agitation - fever, headache, stiff neck, and
vomiting - since returned from summer camp - patient is hallucinating - lumbar puncture - shows cysts
and trophozoites- most likely pathogen? - Answer: a. Olfactory Nerve
Naegleria fowleri
17 year old - ED - 30 minutes after being found with a blank stare. Physical exam shows rigidity. During
exam he becomes hostile and assaults physician - Pt ingested which drug? - Answer: PCP
Placebo controlled clinical trial - 5000 pts with essential hypertension. 2500 patients receive new drug
and 2500 patients receive placebo. If alpha is set at 0.01 instead of 0.05, which of the following is most
likely result? - Answer: Significant findings can be reported with greater confidence
17 year old - gymnast - comes to hospital because of lack of menstrual period for 6 months. BMI 15
Which is the cause of the amenorrhea? - Answer: Hypogonadotropic Hypogonadism
A male stillborn is delivered at 32 weeks - Oligohydramnios - absence of a urethral opening. Which is
most likely finding? - Answer: Pulmonary Hypoplasia
, Page 4 of 742
A 6 day old - breast fed boy in ED - poor weight gain and irritability since delivery - Physical exam shows
jaundice and hepatomegaly. The concentration of which of the following metabolites is most likely
increased? - Answer: a. Galactose - 1 - phosphate
b. Congenital intolerance to breast milk
A 25-year-old man - comes to ED - severe muscle pain, diffuse, painful swelling of his neck, underarms,
and groin after camping in New Mexico Generalized scattered black maculae. Examination of the right
upper extremity shows erythematous, solid, tender mass. Mass is draining blood and necrotic material.
The most effective antibiotic for patient disorder will interfere with which of the following processes? -
Answer: a. Ribosomal Assembly
b. Yersenia Pestis
45 year old - progressive weakness - muscle fasciculations of the upper extremities and weakness of the
lower extremity - What additional findings? - Answer: Atrophy
b. ALS = Lou Gherig
A new severe respiratory illness - Why use a killed vaccine vs a live vaccine? - Answer: Avoids Concerns
of reversion to virulence
b. Killed vaccines - avoids reversion to virulence
c. live vaccines - can (but rarely do) cause the disease they're designed to prevent
A 33 year old - keratinizing squamous cell carcinoma of cervix. Which of the following describes
pathogenesis of this patient's disease? - Answer: Inactivation of Cellular P53
b. p53 protein = tumor suppressor (it activates apoptosis) - most human cancer
A 54 year old - 40 year history of T1DM - receiving hemodialysis for end stage renal disease while
awaiting a kidney transplant. Receives a drug that induces reticulocyte release from bone marrow and
stimulates a cytokine receptor that signals Jak/Stat pathway? - Answer: Erythropoietin
Jak Stat - erythropoietin
During a clinical study examining the effects of exercise. The average pulse is 175/min. Compared with
measurement before the session, which is most likely decreased? - Answer: Total Peripheral Resistance
