@xz
@xz
TestBanksAdept
, Chapter 1: Principles of Pharmacology
Multiple Choice
1. refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations
in function.
a. Drug action; therapeutic effects
b. Side effects; drug effects
c. Therapeutic effects; side effects
d. Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action
2. After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as
a. the therapeutic dose.
b. first-pass effects.
c. bioavailability.
d. ED50.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
3. The specific molecular changes that occur when a drug binds to a particular target site
or receptor are referred to as
a. drug effects.
b. drug action.
c. side effects.
d. placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action
4. Which of the following is not a possible explanation for placebo effects?
a. Pavlovian conditioning
b. Genetic variation
c. Drug competition
d. Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action
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,5. The administration @xzof @xzoxytocin @xzhas @xzbeen @xzproposed @xzas @xza @xztreatment @xzfor
@xzautism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: @xzc
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
6. Which @xzfactor @xzdoes @xznot @xzaffect @xzthe @xzpharmacokinetics @xzof @xza @xzdrug?
a. Route @xzof @xzadministration
b. Lipid @xzsolubility
c. Depot @xzbinding
d. Drug @xzaction
Answer: @xzd
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
7. First-pass @xzmetabolism @xzoccurs @xzwhen @xzdrugs @xzare @xztaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: @xza
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
8. The @xzarea @xzpostrema @xzis @xzone @xzarea @xzin @xzthe @xzbrain @xzwhere @xzthe is @xznot @xzcomplete.
a. cerebrospinal @xzfluid
b. blood–brain @xzbarrier
c. choroid @xzplexus
d. phospholipid @xzmembrane
Answer: @xzb
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
9. First-pass @xzmetabolism @xzoccurs @xzwith @xzorally @xzadministered @xzdrugs @xzbecause
a. their @xzabsorption @xzis @xzslowed @xzby @xzfood.
b. drugs @xzabsorbed @xzinto @xzthe @xzbloodstream @xzfrom @xzthe @xzstomach @xzgo @xzto @xzthe
@xzliver @xzon @xzthe @xzway @xzto @xzgeneral @xzcirculation.
c. drugs @xzmust @xzfirst @xzsurvive @xzthe @xzacidic @xzenvironment @xzof @xzthe @xzstomach.
d. salivary @xzenzymes @xzin @xzthe @xzmouth @xzbegin @xzthe @xzprocess @xzof @xzmetabolism.
Answer: @xzb
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
10. Toxic @xzsubstances @xzin @xzthe @xzblood @xztrigger @xza @xzvomiting @xzresponse @xzby @xzactivating
@xzthe
a. blood–brain @xzbarrier.
b. choroid @xzplexus.
c. area @xzpostrema.
d. median @xzeminence.
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, Answer: @xzc
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
11. Drugs @xzadministered @xz_ have @xzthe @xzmost @xzrapid @xzonset @xzof @xzaction.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: @xzd
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
12. Ionization @xzof @xza @xzdrug @xzdepends @xzon @xzthe of @xzthe @xzsolution @xzand @xzthe of
@xzthe @xzdrug.
a. pH; @xzpKa
b. pKa; @xzpH
c. concentration; @xzlipid @xzsolubility
d. pH; @xzconcentration
Answer: @xza
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
13. The @xzabsorption @xzof @xza @xzdrug @xzdepends @xzon @xzall @xzof @xzthe @xzfollowing @xzexcept
a. lipid @xzsolubility.
b. ionization.
c. body @xztemperature.
d. the @xzconcentration @xzof @xzthe @xzdrug.
Answer: @xzc
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
14. Drugs @xzthat @xzare should @xzbe @xzavoided @xzby @xzwomen @xzof @xzchildbearing @xzage.
a. teratogenic
b. able @xzto @xzcross @xzthe @xzplacental @xzbarrier
c. psychoactive
d. highly @xzlipid-soluble
Answer: @xza
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
15. Agents @xzthat @xzinduce @xzdevelopmental @xzabnormalities @xzin @xza @xzfetus @xzare @xzknown @xzas
a. psychoactive @xzdrugs.
b. illicit @xzdrugs.
c. teratogens.
d. placental @xzdrugs.
Answer: @xzc
Textbook @xzReference: @xzPharmacokinetic @xzFactors @xzDetermining @xzDrug @xzAction
16. Depot @xzbinding @xzis @xzsaid @xzto @xzoccur @xzwhen @xzdrugs
a. bind @xzto @xztheir @xztarget @xzsites.
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