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PCOL 838b Exam 1 (2025/2026) – 65 Verified Questions & Answers | Immunology, Hypersensitivity, Hematology, Coagulation & Pulmonary Pharmacology

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This high-quality exam guide for PCOL 838b (Immunopharmacology) includes 65 fully answered and verified questions from the 2025/2026 academic session, all graded A+. It provides concise yet comprehensive responses to key immunological and pharmacological topics, including MHC Class I and II mechanisms, humoral and cell-mediated immunity, hypersensitivity types (I–IV), autoimmune disorders (e.g., lupus, rheumatoid arthritis), and primary immunodeficiencies (e.g., X-linked agammaglobulinemia, DiGeorge syndrome). It also thoroughly addresses hematopoiesis, blood cell markers, key diagnostic tests (e.g., NBT, ferritin, transferrin, MCV), and the coagulation cascade—covering initiation, amplification, and propagation phases, along with regulatory proteins like antithrombin and protein C. Pulmonary pathologies such as asthma, emphysema, pulmonary fibrosis, and bronchitis are explained alongside pharmacological treatments including corticosteroids, beta-2 agonists, leukotriene receptor antagonists, and anti-cholinergics. This document is especially relevant for students enrolled in: – Pharmacology – Medicine (MD, MBBS) – Biomedical Sciences – Immunology – Pathology – Nursing (BSN, MSN) – Physician Assistant (PA) – Clinical Laboratory Sciences – Pharmacy (PharmD) It is an ideal resource for both course preparation and standardized exams involving immunopharmacological content, such as USMLE, NCLEX, or graduate-level assessments. The questions are formatted for rapid review and understanding, making it perfect for last-minute exam revision or in-depth study sessions. Keywords: MHC I, MHC II, CD4, CD8, B cells, T cells, isotype switching, somatic recombination, hypersensitivity, autoimmune disease, X-linked agammaglobulinemia, DiGeorge syndrome, lupus, rheumatoid arthritis, immunodeficiency, hematopoiesis, ferritin, transferrin, coagulation cascade, thrombin, antithrombin, asthma, COPD, bronchitis, pulmonary fibrosis, corticosteroids, beta-2 agonists, leukotriene antagonists

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PCOL 838b Exam 1 2025/2026 Exam
Questions and Verified Answers |
Already Graded A+



MHC Class I - 🧠 ANSWER ✔✔display antigens from intracellular pathogens


interact with CD8

expressed on ALL cells


MCH Class II - 🧠 ANSWER ✔✔display antigens from extracellular pathogens.


interact with CD4

expressed on APCs


humoral immunity - 🧠 ANSWER ✔✔antibody-mediated immunity


involves B cells

, cell-mediated immunity - 🧠 ANSWER ✔✔type of immunity produced by T cells

that attack infected or abnormal body cells


isotype of antibody - 🧠 ANSWER ✔✔determined by constant region of heavy

chain


somatic recombination - 🧠 ANSWER ✔✔gene segments of antibody rearrange to

form variable domain gene


junctional diversity - 🧠 ANSWER ✔✔source of antibody diversity


RAG yields DNA hairpin which is then cleaved, TdT adds nucleotides at random,

gaps filled by DNA synthesis


isotope class switching - 🧠 ANSWER ✔✔VDJ region is brought to a new constant

region of the heavy chain

heavy chain constant region determined by cytokines

constant region=isotype


isotype class switching signals - 🧠 ANSWER ✔✔1. CD40 ligand (on T cell)

interacts with CD40 on B cell

2. Cytokine determines isotype class

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