ANCC Domain 1 questions 2025 with
Answers
What direct-acting dopamine receptor agonist is recommended to be used in the
treatment of neuroleptic malignant syndrome (NMS) to help lower the dopamine
receptor blockade?
A. Dantrolene (Dantrium)
B. Benztropine (Cogentin)
C. Bromocriptine (Parlodel)
D. Trihexyphenidyl (Artane) - ANSWER-C. Bromocriptine (Parlodel)
A 74 y/o female present for an evaluation. The psychiatric nurse practitioner has
the patient complete the mini mental status examination and clock drawing. The
patient is unable to correctly draw the face of the clock. Which area of the brain is
likely to have compromised functioning?
A. Corpus callosum
B. Wernicke's Area
C. Left Hemisphere
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,D. Right Hemisphere - ANSWER-D. Right Hemisphere
Which of the following statements reflects current understanding of
neurodevelopment and best explains risk-taking behaviors of adolescent males?
A. Stimulant and substance use impairs judgment and cognitive appraisal
B. Pruning of serotonin circuits in the adolescent brain is associated with increased
impulsivity
C. Maturation of the prefrontal cortex continues into mid-20s and early 30s
D. Hormonal flooding, especially testosterone and oxytocin, increase dopamine
levels in the brain - ANSWER-C. Maturation of the prefrontal cortex continues
into mid-20s and early 30s
What cytochrome (CYP) enzyme is implicated as a tobacco inducer when an
individual is treated on clozapine?
A. 2C19
B. 1A2
C. 2C9
D. 2D6 - ANSWER-B. 1A2
As a psychiatric mental health nurse practitioner, you are aware of antipsychotic
medication side effects. Which of the following side effects of antipsychotic
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, medications has an insidious, delayed-onset typically 1 to 2 years after initiation of
the medication?
A. Sedation
B. Weight gain
C. Tardive dyskinesia
D. Dry mouth - ANSWER-C. Tardive dyskinesia
Which mood stabilizer is most associated with a potentially life-threatening rash?
A. Divalproex (depakote)
B. Carbamazepine (tegretol)
C. Lithium (eskalith)
D. Lamotrigine (lamictal) - ANSWER-D. Lamotrigine (lamictal)
The psychiatric-Mental Health Nurse Practitioner would expect to see which of the
following during a physical exam for a patient with bulimia nervosa?
A. Alopecia areata
B. Tachycardia
C. Erosion of dental enamel
D. Obesity - ANSWER-C. Erosion of dental enamel
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Answers
What direct-acting dopamine receptor agonist is recommended to be used in the
treatment of neuroleptic malignant syndrome (NMS) to help lower the dopamine
receptor blockade?
A. Dantrolene (Dantrium)
B. Benztropine (Cogentin)
C. Bromocriptine (Parlodel)
D. Trihexyphenidyl (Artane) - ANSWER-C. Bromocriptine (Parlodel)
A 74 y/o female present for an evaluation. The psychiatric nurse practitioner has
the patient complete the mini mental status examination and clock drawing. The
patient is unable to correctly draw the face of the clock. Which area of the brain is
likely to have compromised functioning?
A. Corpus callosum
B. Wernicke's Area
C. Left Hemisphere
....COPYRIGHT ©️ 2025 ALL RIGHTS RESERVED...TRUSTED & VERIFIED 1
,D. Right Hemisphere - ANSWER-D. Right Hemisphere
Which of the following statements reflects current understanding of
neurodevelopment and best explains risk-taking behaviors of adolescent males?
A. Stimulant and substance use impairs judgment and cognitive appraisal
B. Pruning of serotonin circuits in the adolescent brain is associated with increased
impulsivity
C. Maturation of the prefrontal cortex continues into mid-20s and early 30s
D. Hormonal flooding, especially testosterone and oxytocin, increase dopamine
levels in the brain - ANSWER-C. Maturation of the prefrontal cortex continues
into mid-20s and early 30s
What cytochrome (CYP) enzyme is implicated as a tobacco inducer when an
individual is treated on clozapine?
A. 2C19
B. 1A2
C. 2C9
D. 2D6 - ANSWER-B. 1A2
As a psychiatric mental health nurse practitioner, you are aware of antipsychotic
medication side effects. Which of the following side effects of antipsychotic
....COPYRIGHT ©️ 2025 ALL RIGHTS RESERVED...TRUSTED & VERIFIED 2
, medications has an insidious, delayed-onset typically 1 to 2 years after initiation of
the medication?
A. Sedation
B. Weight gain
C. Tardive dyskinesia
D. Dry mouth - ANSWER-C. Tardive dyskinesia
Which mood stabilizer is most associated with a potentially life-threatening rash?
A. Divalproex (depakote)
B. Carbamazepine (tegretol)
C. Lithium (eskalith)
D. Lamotrigine (lamictal) - ANSWER-D. Lamotrigine (lamictal)
The psychiatric-Mental Health Nurse Practitioner would expect to see which of the
following during a physical exam for a patient with bulimia nervosa?
A. Alopecia areata
B. Tachycardia
C. Erosion of dental enamel
D. Obesity - ANSWER-C. Erosion of dental enamel
....COPYRIGHT ©️ 2025 ALL RIGHTS RESERVED...TRUSTED & VERIFIED 3
